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Suspected very early inflammatory rheumatic diseases in primary care. (2019)
Journal Article
Mallen, & Hider. (2019). Suspected very early inflammatory rheumatic diseases in primary care. https://doi.org/10.1016/j.berh.2019.06.00

As primary care clinicians are typically the first point of contact for patients with musculoskeletal problems, they are crucial to the early diagnosis and treatment of patients with an incident inflammatory arthritis, like rheumatoid arthritis. Curr... Read More about Suspected very early inflammatory rheumatic diseases in primary care..

The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. (2019)
Journal Article
Nowakowska, M., Zghebi, S. S., Ashcroft, D. M., Buchan, I., Chew-Graham, C., Holt, T., …Kontopantelis, E. (2019). The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. BMC Medicine, https://doi.org/10.1186/s12916-019-1373-y

BACKGROUND: The presence of additional chronic conditions has a significant impact on the treatment and management of type 2 diabetes (T2DM). Little is known about the patterns of comorbidities in this population. The aims of this study are to quanti... Read More about The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort..

Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm (2019)
Journal Article
Konstantinou, K., Dunn, K., Windt, D., Ogollah, R., Jasani, V., & Foster, N. (2019). Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-019-2686-x

Background Sciatica is a painful condition managed by a stepped care approach for most patients. Currently, there are no decision-making tools to guide matching care pathways for patients with sciatica without evidence of serious pathology, early in... Read More about Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm.

Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England (2019)
Journal Article
Mallen. (2019). Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England. Canadian Medical Association Journal, E680 - E688. https://doi.org/10.1503/cmaj.190178

BACKGROUND: Most patients with polymyalgia rheumatica or giant cell arteritis are treated with glucocorticoid therapy in primary care. We estimated dose-response risks of infection for this population in England. METHODS: We conducted a retrospect... Read More about Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England.

Gender-specific risk factors for gout: a systematic review of cohort studies (2019)
Journal Article
Evans, P. L., Prior, J. A., Belcher, J., Hay, C. A., Mallen, C. D., & Roddy, E. (2019). Gender-specific risk factors for gout: a systematic review of cohort studies. Advances in Rheumatology, 59, Article 24. https://doi.org/10.1186/s42358-019-0067-7

BACKGROUND: Though gout is more prevalent in men than women, it remains unclear whether gender influences risk factors for incident gout. We aimed to systematically review all cohort studies examining risk factors for the development of gout by gend... Read More about Gender-specific risk factors for gout: a systematic review of cohort studies.

OP0267 INACTIVATED INFLUENZA VACCINATION DOES NOT ASSOCIATE WITH DISEASE FLARES IN AUTOIMMUNE RHEUMATIC DISEASES: A SELF-CONTROLLED CASE SERIES STUDY USING DATA FROM THE CLINICAL PRACTICE RESEARCH DATALINK (2019)
Presentation / Conference
Nakafero, G., Grainge, M., Myles, P., Mallen, C., Zhang, W., Doherty, M., …Abhishek, A. (2019, June). OP0267 INACTIVATED INFLUENZA VACCINATION DOES NOT ASSOCIATE WITH DISEASE FLARES IN AUTOIMMUNE RHEUMATIC DISEASES: A SELF-CONTROLLED CASE SERIES STUDY USING DATA FROM THE CLINICAL PRACTICE RESEARCH DATALINK. Paper presented at Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019

2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout. (2019)
Journal Article
Richette, P., Doherty, M., Pascual, E., Barskova, V., Becce, F., Castaneda, J., …Bardin, T. (2019). 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout. Annals of the Rheumatic Diseases, 79(1), 31 - 38. https://doi.org/10.1136/annrheumdis-2019-215315

Although gout is the most common inflammatory arthritis, it is still frequently misdiagnosed. New data on imaging and clinical diagnosis have become available since the first EULAR recommendations for the diagnosis of gout in 2006. This prompted a sy... Read More about 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout..

Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy. (2019)
Journal Article
Mallen, C., Roddy, E., Clarson, L., & Muller, S. (2019). Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy. Canadian Medical Association Journal, 191(22), E597 - E603. https://doi.org/10.1503/cmaj.180717

BACKGROUND: Systemic inflammatory diseases have been associated with increased risk of venous thromboembolism. We aimed to quantify the risk of venous thromboembolism in patients with gout, the most common inflammatory arthritis, and to assess how di... Read More about Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy..

Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review (2019)
Journal Article
Mallen, Chew-Graham, & Mamas. (2019). Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review. Diabetic Medicine, 688-701. https://doi.org/10.1111/dme.13905

Aims To identify and critically appraise measures that use clinical data to grade the severity of Type 2 diabetes. Methods We searched MEDLINE, Embase and PubMed between inception and June 2018. Studies reporting on clinical data-based diabetes-... Read More about Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review.

Matching treatment options for risk sub-groups in musculoskeletal pain: a consensus groups study (2019)
Journal Article
Protheroe, J., Saunders, B., Bartlam, B., Dunn, K., Cooper, V., Campbell, P., …Foster, N. (2019). Matching treatment options for risk sub-groups in musculoskeletal pain: a consensus groups study. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-019-2587-z

Background Musculoskeletal (MSK) pain represents a considerable worldwide healthcare burden. This study aimed to gain consensus from practitioners who work with MSK pain patients, on the most appropriate primary care treatment options for subgroups... Read More about Matching treatment options for risk sub-groups in musculoskeletal pain: a consensus groups study.

The association of pain and stiffness with fatigue in incident polymyalgia rheumatica: baseline results from the polymyalgia rheumatica cohort study (2019)
Report
Prior, J., Muller, S., Helliwell, T., Hider, S., Barraclough, K., Dasgupta, B., & Mallen, C. (2019). The association of pain and stiffness with fatigue in incident polymyalgia rheumatica: baseline results from the polymyalgia rheumatica cohort study

We aimed to examine the association between pain, stiffness and fatigue in newly diagnosed polymyalgia rheumatica (PMR) patients using baseline data from a prospective cohort study. Fatigue is a known, but often ignored symptom of PMR. Newly diagnose... Read More about The association of pain and stiffness with fatigue in incident polymyalgia rheumatica: baseline results from the polymyalgia rheumatica cohort study.

Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey (2019)
Journal Article
Hider, S. L., Muller, S., Helliwell, T., Prior, J. A., Scott, I., Lawton, S. A., …Mallen, C. D. (2019). Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey. Rheumatology, 58(11), 2009-2014. https://doi.org/10.1093/rheumatology/kez184

Objectives: To describe the prevalence of self-reported inflammatory joint symptoms, such as joint pain, stiffness and swelling in UK primary care patients consulting for both musculoskeletal (MSK) and non-musculoskeletal (non-MSK) complaints. Met... Read More about Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey.

Temporal relationships between systemic lupus erythematosus and comorbidities (2019)
Journal Article
Mallen. (2019). Temporal relationships between systemic lupus erythematosus and comorbidities. Rheumatology, 840-848. https://doi.org/10.1093/rheumatology/key335

Objective To examine the burden of comorbidities prior to and after the diagnosis of SLE and its impact on mortality. Methods We identified 1605 incident cases of SLE and 6284 matched controls from the UK primary care. The risks of comorbidities... Read More about Temporal relationships between systemic lupus erythematosus and comorbidities.

Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease modifying anti-rheumatic drugs. (2019)
Journal Article
Mallen. (2019). Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease modifying anti-rheumatic drugs. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2019-215086

Objectives To examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis and unexplained fever in people w... Read More about Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease modifying anti-rheumatic drugs..

O27 Long-term effect of allopurinol use on serum uric acid levels, mortality and comorbidities in gout patients: an electronic health record cohort study (2019)
Journal Article
Rathod-Mistry, T., Roddy, E., Jordan, K., Mallen, C. D., & Blagojevic-Bucknall, M. (2019). O27 Long-term effect of allopurinol use on serum uric acid levels, mortality and comorbidities in gout patients: an electronic health record cohort study. Rheumatology, 58(Supplement_3), https://doi.org/10.1093/rheumatology/kez105.026

202 Gout attack trajectories in a 3-year cohort study in primary care (2019)
Journal Article
Watson, L., Belcher, J., Mallen, C. D., & Roddy, E. (2019). 202 Gout attack trajectories in a 3-year cohort study in primary care. Rheumatology, 58(Supplement_3), https://doi.org/10.1093/rheumatology/kez107.018

Background: Gout affects 2.5% of adults in the UK but is often poorly managed. Whilst the hallmark of gout is recurrent sudden-onset attacks of acute joint pain and swelling, little is known about the pattern (trajectory) of attacks over time. We aim... Read More about 202 Gout attack trajectories in a 3-year cohort study in primary care.