Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial.

Holden, MA; Callaghan, M; Felson, D; Birrell, F; Nicholls, E; Jowett, S; Kigozi, J; McBeth, J; Borrelli, B; Jinks, C; Foster, NE; Dziedzic, K; Mallen, C; Sutton, A; Ingram, C; Lawton, S; Hartshorne, L; Williams, H; Browell, R; Hudson, H; Marshall, M; Sowden, G; Herron, D; Halliday, N; Asamane, E; Peat, G

doi:10.1136/bmjopen-2020-048196

'It's just a great muddle when it comes to food': a qualitative exploration of patient decision-making around diet and gout. (2021)
Journal Article
Hider, Watson, Mallen, & Roddy. (2021). 'It's just a great muddle when it comes to food': a qualitative exploration of patient decision-making around diet and gout. Rheumatology Advances in Practice, https://doi.org/10.1093/rap/rkab055

Objective: Our aim was to understand whether, why and how patients choose to modify their diets after developing gout. Methods: We conducted an inductive thematic secondary analysis of qualitative data from 43 interviews and four focus groups wit... Read More about 'It's just a great muddle when it comes to food': a qualitative exploration of patient decision-making around diet and gout..

Harnessing Placebo Effects in Primary Care: Using the Person-Based Approach to Develop an Online Intervention to Enhance Practitioners' Communication of Clinical Empathy and Realistic Optimism During Consultations. (2021)
Journal Article
Mallen. (2021). Harnessing Placebo Effects in Primary Care: Using the Person-Based Approach to Develop an Online Intervention to Enhance Practitioners' Communication of Clinical Empathy and Realistic Optimism During Consultations. Frontiers in Pain Research, 721222 - ?. https://doi.org/10.3389/fpain.2021.721222

Background: Empathic communication and positive messages are important components of "placebo" effects and can improve patient outcomes, including pain. Communicating empathy and optimism to patients within consultations may also enhance the effects... Read More about Harnessing Placebo Effects in Primary Care: Using the Person-Based Approach to Develop an Online Intervention to Enhance Practitioners' Communication of Clinical Empathy and Realistic Optimism During Consultations..

Improving uptake of Fracture Prevention drug treatments: a protocol for Development of a consultation intervention (iFraP-D) (2021)
Journal Article
Paskins, Z., Bullock, L., Crawford-Manning, F., Cottrell, E., Fleming, J., Leyland, S., …Jinks, C. (2021). Improving uptake of Fracture Prevention drug treatments: a protocol for Development of a consultation intervention (iFraP-D). BMJ Open, 11(8), https://doi.org/10.1136/bmjopen-2021-048811

INTRODUCTION: Prevention of fragility fractures, a source of significant economic and personal burden, is hindered by poor uptake of fracture prevention medicines. Enhancing communication of scientific evidence and elicitation of patient medication-r... Read More about Improving uptake of Fracture Prevention drug treatments: a protocol for Development of a consultation intervention (iFraP-D).

Exploring the Impact of the First Wave of COVID-19 on Social Work Practice: A Qualitative Study in England, UK (2021)
Journal Article
Kingstone, T., Campbell, P., Andras, A., Nixon, K., Mallen, C., Dikomitis, L., …Wenning, B. (2021). Exploring the Impact of the First Wave of COVID-19 on Social Work Practice: A Qualitative Study in England, UK. British Journal of Social Work, 52(4), 2043–2062. https://doi.org/10.1093/bjsw/bcab166

The COVID-19 pandemic signalled a radical shift in health and social care services globally. In UK, many of the people with existing social care needs were identified as 'clinically vulnerable' to COVID-19. Those at greatest risk were encouraged to a... Read More about Exploring the Impact of the First Wave of COVID-19 on Social Work Practice: A Qualitative Study in England, UK.

Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis (2021)
Journal Article
Yahaya, I., Wright, T., Babatunde, O., Corp, N., Helliwell, T., Dikomitis, L., & Mallen, C. (2021). Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis. Rheumatology International, 41, 1221-1231. https://doi.org/10.1007/s00296-021-04838-y

Evidence from the Global Burden of Disease studies suggests that osteoarthritis (OA) is a significant cause of disability globally; however, it is less clear how much of this burden exists in low-income and lower middle-income countries. This study a... Read More about Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis.

Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. (2021)
Journal Article
Mamas, M., & Mallen, C. (2021). Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. Research Square, https://doi.org/10.21203/rs.3.rs-670522/v1

Objectives: To examine the association between ß -blocker prescription and knee or hip total joint replacement (TJR) in a UK primary-care population with incident knee or hip osteoarthritis (OA). Methods: Cohort study using data from the Clinical P... Read More about Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink..

The impact of COVID-19 on primary care in Europe (2021)
Journal Article
McKee, M., Mughal, F., & Mallen, C. (2021). The impact of COVID-19 on primary care in Europe. The Lancet Regional Health Europe, https://doi.org/10.1016/j.lanepe.2021.100152

'Editorial Material'

Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis (2021)
Journal Article
Hay, C. A., Prior, J. A., Belcher, J., Mallen, C. D., & Roddy, E. (2021). Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis. Arthritis Care & Research, 73(7), 1049-1054. https://doi.org/10.1002/acr.24205

ObjectiveUrate‐lowering therapy (predominantly allopurinol) is highly effective as a treatment for gout, but its wider long‐term effects remain unclear. This systematic review and meta‐analysis aimed to ascertain the association between mortality and... Read More about Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis.

Refinement and validation of a tool for stratifying patients with musculoskeletal pain (2021)
Journal Article
Dunn, K. M., Campbell, P., Lewis, M., Hill, J. C., van der Windt, D. A., Afolabi, E., …Foster, N. E. (2021). Refinement and validation of a tool for stratifying patients with musculoskeletal pain. European Journal of Pain, 25(10), 2081-2093. https://doi.org/10.1002/ejp.1821

AbstractBackgroundPatients with musculoskeletal pain in different body sites share common prognostic factors. Using prognosis to stratify and treatment match can be clinically and cost‐effective. We aimed to refine and validate the Keele STarT MSK To... Read More about Refinement and validation of a tool for stratifying patients with musculoskeletal pain.

Missed opportunities in coronary artery disease: reflection on practice to improve patient outcomes (2021)
Journal Article
Kwok, C. S., Satchithananda, D., & Mallen, C. D. (2021). Missed opportunities in coronary artery disease: reflection on practice to improve patient outcomes. Coronary Artery Disease, 33(3), 233-238. https://doi.org/10.1097/MCA.0000000000001075

Missed opportunities refer to incidents where different actions by those involved could result in more desirable outcomes. While missed opportunities is not an established concept in coronary artery disease (CAD), they are important because CAD is co... Read More about Missed opportunities in coronary artery disease: reflection on practice to improve patient outcomes.

Missed acute myocardial infarction: an underrecognized problem that contributes to poor patient outcomes. (2021)
Journal Article
Mallen. (2021). Missed acute myocardial infarction: an underrecognized problem that contributes to poor patient outcomes. Coronary Artery Disease, 345-349. https://doi.org/10.1097/MCA.0000000000000975

Ischemic heart disease is the number one killer in the world. While improvements in the management of acute myocardial infarction (AMI) have resulted in lower mortality rates, there are still cases where AMI is missed with rates varying depending on... Read More about Missed acute myocardial infarction: an underrecognized problem that contributes to poor patient outcomes..

Misdiagnosis of heart failure: A systematic review of the literature (2021)
Journal Article
Mallen. (2021). Misdiagnosis of heart failure: A systematic review of the literature. Journal of Cardiac Failure, 925-933. https://doi.org/10.1016/j.cardfail.2021.05.014

Background Heart failure (HF) is a chronic disease associated with a significant burden to patients, families and health services. The diagnosis of HF can be easily missed due to similar symptoms with other conditions especially respiratory diseases... Read More about Misdiagnosis of heart failure: A systematic review of the literature.

Corrigendum to: comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care. (2021)
Journal Article
Mallen. (2021). Corrigendum to: comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care. Health Policy and Planning, 341-356. https://doi.org/10.1093/heapol/czab046

Metformin use and the risk of total knee replacement among diabetic patients in primary care (2021)
Presentation / Conference
Sit, R., Lai, F., Yip, B., Hunter, D., Rabago, D., Mallen, C., & Wong, S. (2021, April). Metformin use and the risk of total knee replacement among diabetic patients in primary care. Presented at Virtual 2021 OARSI World Congress on Osteoarthritis, Virtual

Purpose: Metformin, apart from its glucose lowering and weight reduction effects, has recently been shown to modulate meta-inflammation, an important pathogenesis in knee osteoarthritis (OA). We aim to study the association between regular metformin... Read More about Metformin use and the risk of total knee replacement among diabetic patients in primary care.

PREVALENCE OF FRAGILITY FRACTURES AND MEDICATION PRESCRIPTION FOR OSTEOPOROSIS IN PATIENTS WITH POLYMYALGIA RHEUMATICA: RESULTS FROM THE PMR COHORT STUDY (2021)
Journal Article
Singh Sokhal, B., Hider, S. L., Paskins, Z., Muller, S., & Mallen, C. D. (2021). PREVALENCE OF FRAGILITY FRACTURES AND MEDICATION PRESCRIPTION FOR OSTEOPOROSIS IN PATIENTS WITH POLYMYALGIA RHEUMATICA: RESULTS FROM THE PMR COHORT STUDY. Rheumatology, 60(S1), Article ARTN keab246.002. https://doi.org/10.1093/rheumatology/keab246.002

Background/Aims Polymyalgia rheumatica (PMR) is one of the commonest indications for long term glucocorticoid (GC) use, leading to an increased risk of osteoporosis and fragility fractures. Clinical guidelines recommend prescribing medication includ... Read More about PREVALENCE OF FRAGILITY FRACTURES AND MEDICATION PRESCRIPTION FOR OSTEOPOROSIS IN PATIENTS WITH POLYMYALGIA RHEUMATICA: RESULTS FROM THE PMR COHORT STUDY.

The patient, clinician and healthcare perspectives in evaluating care pathways for stable chest pain. (2021)
Journal Article
Kwok, C. S., Duckett, S., Satchithananda, D., Potluri, R., Morgan-Smith, D., Bellenger, N., …Mallen, C. D. (2021). The patient, clinician and healthcare perspectives in evaluating care pathways for stable chest pain. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine, 20(3), 143-148. https://doi.org/10.1097/HPC.0000000000000261

Chest pain is one of the most common reasons for patients to present to healthcare professionals. One of the main challenges with the management of chest pain is the wide differential diagnosis, ranging from minor chest trauma to potentially life thr... Read More about The patient, clinician and healthcare perspectives in evaluating care pathways for stable chest pain..

Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. (2021)
Journal Article
Mamas, Mallen, & Chew-Graham. (2021). Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. Open Heart, https://doi.org/10.1136/openhrt-2020-001498

OBJECTIVE: Most current cardiovascular disease (CVD) risk stratification tools are for people without CVD, but very few are for prevalent CVD. In this study, we developed and validated a CVD severity score in people with coronary heart disease (CHD)... Read More about Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study..

Self-management advice, exercise and foot orthoses for plantar heel pain: the TREADON pilot and feasibility randomised trial (2021)
Journal Article
Chesterton, L. S., Thomas, M. J., Hendry, G., Chen, Y., Goddin, D., Halliday, N., …Roddy, E. (2021). Self-management advice, exercise and foot orthoses for plantar heel pain: the TREADON pilot and feasibility randomised trial. Pilot and Feasibility Studies, 7, Article 92. https://doi.org/10.1186/s40814-021-00808-0

Plantar heel pain (PHP) is common and impacts negatively on physical function and quality of life. Initial treatment usually comprises analgesia and self-management advice (SMA), with referral to a physiotherapist or podiatrist recommended only when... Read More about Self-management advice, exercise and foot orthoses for plantar heel pain: the TREADON pilot and feasibility randomised trial.

Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care. (2021)
Journal Article
Mallen. (2021). Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care. British Journal of General Practice (BJGP), e296-e302. https://doi.org/10.3399/bjgp21X714281

BACKGROUND: In 2011, National Institute for Health and Care Excellence (NICE) guidelines recommended the routine use of out-of-office blood pressure (BP) monitoring for the diagnosis of hypertension. These changes were predicted to reduce unnecessary... Read More about Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care..

Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. (2021)
Journal Article
Holden, M., Callaghan, M., Felson, D., Birrell, F., Nicholls, E., Jowett, S., …Peat, G. (2021). Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. BMJ Open, 11(3), Article e048196. https://doi.org/10.1136/bmjopen-2020-048196

BACKGROUND: Brace effectiveness for knee osteoarthritis (OA) remains unclear and international guidelines offer conflicting recommendations. Our trial will determine the clinical and cost-effectiveness of adding knee bracing (matched to patients' cli... Read More about Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial..

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