All Outputs (42)

Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. (2024)
Journal Article
Muller, S., Bailey, J., Bajpai, R., Helliwell, T., Harrisson, S. A., Whittle, R., …Ashworth, J. (in press). Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. PAIN, https://doi.org/10.1097/j.pain.0000000000003239

Growing evidence from pharmacovigilance data and postmortem toxicology reports highlights the misuse potential of gabapentinoids. This study aimed to investigate the risk of serious adverse outcomes (drug misuse, overdose, major trauma), and their ri... Read More about Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study..

Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention (2024)
Journal Article
Siciliano, M., Bathers, S., Bentley, I., Bullock, L., Cherrington, A., Clark, E., …Iglesias-Urrutia, C. (in press). Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention. NIHR Open Research, 4(15), https://doi.org/10.3310/nihropenres.13575.1

Background Digital health interventions (DHI) are associated with significant promise. In recent years, the need to assess the value of these healthcare technologies has motivated a debate regarding the suitability of existing economic evaluation me... Read More about Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention.

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol (2024)
Journal Article
Bullock, L., Nicholls, E., Cherrington, A., Butler-Walley, S., Clark, E. M., Fleming, J., …Paskins, Z. (in press). A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol. NIHR Open Research, 4(14), https://doi.org/10.3310/nihropenres.13571.1

Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and val... Read More about A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol.

The SelfSTarT intervention for low back pain patients presenting to first contact physiotherapists: A mixed methods service evaluation (2024)
Journal Article
Stevenson, K., Hadley‐Barrows, T., Evans, N., Campbell, L., Southam, J., Chudyk, A., …Hill, J. C. (2024). The SelfSTarT intervention for low back pain patients presenting to first contact physiotherapists: A mixed methods service evaluation. Musculoskeletal Care, 22(1), Article e1876. https://doi.org/10.1002/msc.1876

Introduction Globally, back pain is the leading cause of years of disability. In the United Kingdom, over 20 million people live with musculoskeletal (MSK) pain, with low back pain being one of the most common causes. National strategies promote sel... Read More about The SelfSTarT intervention for low back pain patients presenting to first contact physiotherapists: A mixed methods service evaluation.

Talking in primary care (TIP): protocol for a cluster-randomised controlled trial in UK primary care to assess clinical and cost-effectiveness of communication skills e-learning for practitioners on patients’ musculoskeletal pain and enablement (2024)
Journal Article
Bishop, F. L., Cross, N., Dewar-Haggart, R., Teasdale, E., Herbert, A., Robinson, M. E., …Everitt, H. A. (2024). Talking in primary care (TIP): protocol for a cluster-randomised controlled trial in UK primary care to assess clinical and cost-effectiveness of communication skills e-learning for practitioners on patients’ musculoskeletal pain and enablement. BMJ Open, 14(3), Article e081932. https://doi.org/10.1136/bmjopen-2023-081932

Introduction: Effective communication can help optimise healthcare interactions and patient outcomes. However, few interventions have been tested clinically, subjected to cost-effectiveness analysis or are sufficiently brief and well-described for im... Read More about Talking in primary care (TIP): protocol for a cluster-randomised controlled trial in UK primary care to assess clinical and cost-effectiveness of communication skills e-learning for practitioners on patients’ musculoskeletal pain and enablement.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., …Abhishek, A. (2024). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, Article keae175. https://doi.org/10.1093/rheumatology/keae175

To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s). Adults (≥18 years) taking... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (in press). Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study. Rheumatology, https://doi.org/10.1093/rheumatology/keae160

Objective The uptake and safety of pneumococcal vaccination in people with immune-mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK-wide pneumococcal vaccine uptake in adults with IMIDs and explored the association... Read More about Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study.

Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study (2024)
Journal Article
Hay, C. A., Packham, J., Prior, J. A., Mallen, C. D., & Ryan, S. (2024). Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study. Rheumatology International, 44, 863–884. https://doi.org/10.1007/s00296-024-05554-z

Diagnosis of axial spondyloarthritis (axSpA) is frequently delayed for years after symptom onset. However, little is known about patient and healthcare professional (HCP) perspectives on barriers and facilitators in axSpA diagnosis. This study explor... Read More about Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article
Abhishek, A., Grainge, M., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., …Riley, R. (2024). Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation. RMD Open, 10(1), Article e003980. https://doi.org/10.1136/rmdopen-2023-003980

Background: Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Health Literacy and Gout Characteristics in a Primary Care Cohort (2024)
Journal Article
Watson, L., Protheroe, J., Mallen, C., Muller, S., & Roddy, E. (2024). Health Literacy and Gout Characteristics in a Primary Care Cohort. Rheumatology Advances in Practice, 8(2), Article rkae034. https://doi.org/10.1093/rap/rkae034

Objectives To examine the cross-sectional association between health literacy and gout characteristics. Methods In a primary care cohort of adults living with gout, the prevalence of poor health literacy was defined using the Single-Item Literac... Read More about Health Literacy and Gout Characteristics in a Primary Care Cohort.

Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals (2024)
Journal Article
Simkins, J., Holden, M. A., Babatunde, O., White, S., Nicholls, E., Long, A., …O’Brien, N. (2024). Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals. Musculoskeletal Care, 22(1), Article e1873. https://doi.org/10.1002/msc.1873

Introduction Osteoarthritis is the commonest form of chronic joint pain, which patients often self-manage before seeking healthcare advice. Patients frequently seek advice from community pharmacies, and a recent policy has recommended integrating co... Read More about Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals.

“We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations (2024)
Journal Article
Gidlow, C. J., Sams, L., Buckless, K., Ellis, N. J., Duffy, H. C., Lambley-Burke, R., …Mallen, C. D. (2024). “We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations. BMC Health Services Research, 24(1), Article 264. https://doi.org/10.1186/s12913-024-10760-3

The introduction of Integrated Care Systems (ICS) in England aimed to increase joint planning and delivery of health and social care, and other services, to better meet the needs of local communities. There is an associated duty to undertake collabor... Read More about “We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations.

Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease. (2024)
Journal Article
Sokhal, B. S., Menon, S. P. K., Willes, C., Corp, N., Matetić, A., Mallen, C., & Mamas, M. (in press). Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease. Current Cardiology Reviews, 20(3), Article e290224227533. https://doi.org/10.2174/011573403X276647240217112151

There is limited systematic data on the association between the Hospital Frailty Risk Score (HFRS) and characteristics and mortality in patients with cerebrovascular and cardiovascular disease (CVD). This systematic review aimed to summarise the use... Read More about Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease..

Evaluating the impact of the supporting the advancement of research skills (STARS) programme on research knowledge, engagement and capacity-building in a health and social care organisation in England (2024)
Journal Article
Tajuria, G., Dobel-Ober, D., Bradley, E., Charnley, C., Lambley-Burke, R., Mallen, C., …Kingstone, T. (in press). Evaluating the impact of the supporting the advancement of research skills (STARS) programme on research knowledge, engagement and capacity-building in a health and social care organisation in England. BMC Medical Education, 24(1), Article 126. https://doi.org/10.1186/s12909-024-05059-0

Objectives To evaluate the impact a novel education programme - to improve research engagement, awareness, understanding and confidence - had on a diverse health and social care workforce. Barriers and facilitators to engagement were explored togeth... Read More about Evaluating the impact of the supporting the advancement of research skills (STARS) programme on research knowledge, engagement and capacity-building in a health and social care organisation in England.

Betwixt and between student and professional identities: UK medical students during COVID times (2024)
Journal Article
Polidano, K., Wenning, B., Mallen, C. D., & Dikomitis, L. (2024). Betwixt and between student and professional identities: UK medical students during COVID times. SN Social Sciences, 4(2), Article 53. https://doi.org/10.1007/s43545-024-00844-6

The COVID-19 pandemic lockdown in Spring 2020 brought about unprecedented disruption to medical education in the United Kingdom (UK). Medical students were encouraged to take up paid roles in the National Health Service to help with workforce shortag... Read More about Betwixt and between student and professional identities: UK medical students during COVID times.

Trends in Cardiovascular Mortality Among Patients With Alzheimer's Disease in the United States from 1999 to 2020 (2024)
Journal Article
Ranganathan, S., Abramov, D., Chew, N. W., Mallen, C., Marshall, M., Kobo, O., & Mamas, M. A. (2024). Trends in Cardiovascular Mortality Among Patients With Alzheimer's Disease in the United States from 1999 to 2020. The American Journal of Cardiology, 211, 326-333. https://doi.org/10.1016/j.amjcard.2023.11.044

Optimising the implementation of evidence-based osteoarthritis guidelines in primary care: Development of a knowledge mobilisation toolkit (2024)
Journal Article
Swaithes, L., Paskins, Z., Finney, A., Walsh, N., Skrybant, M., Mallen, C., & Dziedzic, K. (2024). Optimising the implementation of evidence-based osteoarthritis guidelines in primary care: Development of a knowledge mobilisation toolkit. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.01.003

Objective Implementing clinical guidelines for osteoarthritis in primary care is complex. Whilst international guidelines detail what best practice for osteoarthritis looks like, little is known about how this is... Read More about Optimising the implementation of evidence-based osteoarthritis guidelines in primary care: Development of a knowledge mobilisation toolkit.

Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA) (2024)
Journal Article
Babatunde, O. O., Cottrell, E., White, S., Chudyk, A., Healey, E. L., Edwards, J., …Holden, M. A. (in press). Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA). BMC Musculoskeletal Disorders, 25(1), Article 54. https://doi.org/10.1186/s12891-023-07105-2

Background Osteoarthritis is a common, painful and disabling long-term condition. Delivery of high-quality guideline-informed osteoarthritis care that successfully promotes and maintains supported self-management is imperative. However, osteoarthrit... Read More about Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA).

EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis: 2023 update. (2024)
Journal Article
Moseng, T., Vliet Vlieland, T. P. M., Battista, S., Beckwée, D., Boyadzhieva, V., Conaghan, P. G., …Østerås, N. (in press). EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis: 2023 update. Annals of the Rheumatic Diseases, https://doi.org/10.1136/ard-2023-225041

Hip and knee osteoarthritis (OA) are increasingly common with a significant impact on individuals and society. Non-pharmacological treatments are considered essential to reduce pain and improve function and quality of life. EULAR recommendations for... Read More about EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis: 2023 update..

Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers (2024)
Journal Article
Pollock, K. G., Dickerson, C., Kainth, M., Lawton, S., Hurst, M., Sugrue, D. M., …Cohen, A. T. (in press). Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers. BMC Primary Care, 25(1), Article 7. https://doi.org/10.1186/s12875-023-02246-8

Background Conducting effective and translational research can be challenging and few trials undertake formal reflection exercises and disseminate learnings from them. Following completion of our multicentre randomised controlled trial, which was im... Read More about Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers.