All Outputs (620)

Methotrexate oral or subcutaneous for rheumatoid arthritis (MOOSE): study protocol for a multi-centre randomised trial (2025)
Journal Article
McClure, S., Haydock, R., Su, Y., Rick, C., Blackburn, S., Brooks, M., Edwards, C. J., Mallen, C., Raza, K., Jinks, C., Stevenson, M., Montgomery, A., Hepburn, T., & Abhishek, A. (2025). Methotrexate oral or subcutaneous for rheumatoid arthritis (MOOSE): study protocol for a multi-centre randomised trial. Trials, 26(1), 495. https://doi.org/10.1186/s13063-025-09020-4

Background: Rheumatoid arthritis is the commonest chronic inflammatory arthritis. Oral methotrexate is recommended as the first-line disease modifying drug for its management, and subcutaneous injections are typically prescribed if there is gastroint... Read More about Methotrexate oral or subcutaneous for rheumatoid arthritis (MOOSE): study protocol for a multi-centre randomised trial.

Experiences of supporting primary and community healthcare workers affected by domestic abuse in the United Kingdom: A cross-sectional survey (2025)
Journal Article
Dheensa, S., Feder, G., Mallen, C., & Gregory, A. (2025). Experiences of supporting primary and community healthcare workers affected by domestic abuse in the United Kingdom: A cross-sectional survey. European Journal of General Practice, 31(1), 2571600. https://doi.org/10.1080/13814788.2025.2571600

Background : Healthcare workers are expected to identify and respond to domestic abuse among patients. However, research has neglected healthcare workers’ own experiences of domestic abuse. Objectives : Focusing on UK primary and community healthcare... Read More about Experiences of supporting primary and community healthcare workers affected by domestic abuse in the United Kingdom: A cross-sectional survey.

Global Trends and Forecast of Cardiovascular Diseases, Cancer, and Shared Risk Factors: Insights From the GBD 2021 (2025)
Journal Article
Koo, C. Y., Chong, B., Jayabaskaran, J., Nagarajan, S., Jauhari, S. M., Chen, Y., Tan, L. L., Mehta, A., Khan, M. S., Muthiah, M., Hausenloy, D., Richards, A. M., Ko, D. T., Mallen, C. D., Secemsky, E. A., Chan, M. Y., Thavendiranathan, P., Chew, N. W. S., & Mamas, M. A. (2025). Global Trends and Forecast of Cardiovascular Diseases, Cancer, and Shared Risk Factors: Insights From the GBD 2021. Journal of the American Heart Association, 14(21), e043629. https://doi.org/10.1161/jaha.125.043629

Background Cardiovascular disease (CVD) and cancer share multiple risk factors and are the leading causes of morbidity and death worldwide. This study aims to examine historical and projected trends of the combined CVD–cancer global estimates and the... Read More about Global Trends and Forecast of Cardiovascular Diseases, Cancer, and Shared Risk Factors: Insights From the GBD 2021.

The quality of care and long-term mortality of patients with ST-elevation myocardial infarction and cardiac devices: A nationwide cohort study (2025)
Journal Article
Weight, N., Singh Sokhal, B., Rashid, M., Dafaalla, M., Mallen, C. D., & Mamas, M. A. (2025). The quality of care and long-term mortality of patients with ST-elevation myocardial infarction and cardiac devices: A nationwide cohort study. European Heart Journal Open, 5(6). https://doi.org/10.1093/ehjopen/oeaf139

Introduction There is a growing population with cardiac devices (pacemakers, implantable cardioverter defibrillators and cardiac resynchronisation therapy), but whether this influences quality of care and long-term mortality after ST-elevation myocar... Read More about The quality of care and long-term mortality of patients with ST-elevation myocardial infarction and cardiac devices: A nationwide cohort study.

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 3; peer review: 3 approved, 1 approved with reservations] (2025)
Other
Bullock, L., Nicholls, E., Cherrington, A., Butler-Walley, S., Clark, E. M., Fleming, J., Leyland, S., Bentley, I., Thomas, S., Iglesias-Urrutia, C. P., Webb, D., Smith, J., Bathers, S., Lewis, S., Clifford, A., Siciliano, M., Protheroe, J., Ryan, S., Lefroy, J., …Paskins, Z. (2025). A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 3; peer review: 3 approved, 1 approved with reservations]. https://doi.org/10.3310/nihropenres.13571.3

Background
Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and val... Read More about A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 3; peer review: 3 approved, 1 approved with reservations].

Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study [version 2; peer review: 1 approved] (2025)
Other
Bullock, L., Cherrington, A., M Clark, E., Fleming, J., Bentley, I., Nicholls, E., Webb, D., Smith, J., Bathers, S., Lewis, S., Horne, R., W O'Neill, T., D Mallen, C., Jinks, C., & Paskins, Z. (2025). Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study [version 2; peer review: 1 approved]. National Institute for Health and Care Research. https://doi.org/10.3310/nihropenres.13751.2

Background
High quality shared decision-making (SDM) conversations involve people with or at risk of osteoporosis and clinicians working together to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and v... Read More about Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study [version 2; peer review: 1 approved].

Delivering a primary care review for people prescribed opioids for persistent pain: facilitators and barriers facing practice pharmacists (2025)
Journal Article
Woodcock, C., Cornwall, N., Harrisson, S. A., Ashworth, J., Dikomitis, L., Helliwell, T., Hodgson, E., Knaggs, R., Mallen, C., Pincus, T., Santer, M., White, S., & Jinks, C. (2025). Delivering a primary care review for people prescribed opioids for persistent pain: facilitators and barriers facing practice pharmacists. British Journal of General Practice Open (BJGP Open), 31, BJGPO.2025.0156. https://doi.org/10.3399/BJGPO.2025.0156

Background: People living with persistent non-cancer pain often are prescribed opioids long-term, despite a lack of evidence for their long-term effectiveness and safety. This study informed the design of a new practice pharmacist-led review (PROMPPT... Read More about Delivering a primary care review for people prescribed opioids for persistent pain: facilitators and barriers facing practice pharmacists.

Trends and inequalities in Advice and Guidance versus direct referral in NHS primary care: a population-based study, 2015–2023 (2025)
Preprint / Working Paper
Mason, K. J., Jordan, K. P., Bailey, J., Bajpai, R., Clarson, L. E., Faux-Nightingale, A., Hadley-Barrows, T., Haines, J., Harrison, R., Helliwell, T., Hider, S. L., Jinks, C., Knight, N., Mallen, C. D., Welsh, V. K., & Burton, C. (2025). Trends and inequalities in Advice and Guidance versus direct referral in NHS primary care: a population-based study, 2015–2023. medrxiv. https://doi.org/10.1101/2025.09.25.25336644

Objective to examine trends and variation in the use of Advice and Guidance (A&G) compared with direct referrals in primary care, and to assess potential disparities across population groups.

Design Observational study using routinely collected el... Read More about Trends and inequalities in Advice and Guidance versus direct referral in NHS primary care: a population-based study, 2015–2023.

Prescriptions of Essentially Placebo Treatments Among General Practitioners in 21 Countries. (2025)
Journal Article
Wolters, F., Peerdeman, K., Gussekloo, J., Adler, L., Asenova, R., Kánská, P. B., Collins, C., Dumitra, G. G., Howick, J., Peštić, S. K., Kurpas, D., Lazic, V., Lingner, H., Mallen, C. D., Missiou, A., Peremans, L., Petrazzuoli, F., Pilv-Toom, L., Poortvliet, R. K. E., …Streit, S. (2025). Prescriptions of Essentially Placebo Treatments Among General Practitioners in 21 Countries. Jama Network Open, 8(9), 1-10, e2532672. https://doi.org/10.1001/jamanetworkopen.2025.32672

General practitioners (GPs) sometimes initiate a treatment despite not expecting it to improve patients' symptoms by any physiological mechanism. These essentially placebo treatments are ethically controversial, and their frequency is unclear. They i... Read More about Prescriptions of Essentially Placebo Treatments Among General Practitioners in 21 Countries..

Sterile water injections for analgesia in renal colic: a meta-analysis of level 1 evidence (2025)
Journal Article
Perros, I., Sokhal, B. S., Swift, C., Kitchen, M., Mallen, C., & Somani, B. (2025). Sterile water injections for analgesia in renal colic: a meta-analysis of level 1 evidence. World Journal of Urology, 43(1), 557. https://doi.org/10.1007/s00345-025-05920-x

Objective: To evaluate the effectiveness of Sterile water injections (SWIs) for acute pain relief in renal colic. Methods: This study was conducted in accordance with the Preferred Reporting items for Systematic Reviews and Meta-Analyses. MEDLINE, CI... Read More about Sterile water injections for analgesia in renal colic: a meta-analysis of level 1 evidence.

Manuscript title: Guideline-informed care for Osteoarthritis: support needs of Community Pharmacists and Healthcare Professionals in Nigeria, West-Africa (2025)
Journal Article
Adetunji, O., Alonge, I., Ayinmode, E., Owoyemi, T., Ogunbanjo, A., White, S., Adebajo, A., Mallen, C., Dziedzic, K., & Babatunde, O. O. (online). Manuscript title: Guideline-informed care for Osteoarthritis: support needs of Community Pharmacists and Healthcare Professionals in Nigeria, West-Africa. Osteoarthritis and Cartilage Open, https://doi.org/10.1016/j.ocarto.2025.100678

Objective
The study examined the context, training needs, and extent to which community pharmacists in Nigeria have the knowledge, resources, and capability to manage OA in line with evidence-based recommendations.
Methods
Focus group discussions... Read More about Manuscript title: Guideline-informed care for Osteoarthritis: support needs of Community Pharmacists and Healthcare Professionals in Nigeria, West-Africa.

Emergency department attendance stratified by cause and frailty status: A national retrospective cohort study (2025)
Journal Article
Sokhal, B. S., Matetić, A., Protheroe, J., Helliwell, T., Myint, P. K., Paul, T. K., Mallen, C. D., & Mamas, M. A. (in press). Emergency department attendance stratified by cause and frailty status: A national retrospective cohort study. Geriatrics and Gerontology International, https://doi.org/10.1111/ggi.70153

Aim: The aim of this study was to determine whether the causes of emergency department (ED) attendance and clinical outcomes vary by frailty status. Methods: Using the Nationwide ED Sample, causes of attendance were stratified by Hospital Frailty Ris... Read More about Emergency department attendance stratified by cause and frailty status: A national retrospective cohort study.

The Michael Mason Prize: Development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine (2025)
Journal Article
Bullock, L., Tyler, N., Fleming, J., Clark, E. M., Thomas, S., Gidlow, C., Iglesias-Urrutia, C. P., Horne, R., Bentley, I., Hawarden, A., Peel, N., Gregson, C. L., Ralston, S. H., Protheroe, J., Lefroy, J., Ryan, S., O’Neill, T. W., Mallen, C., Jinks, C., & Paskins, Z. (2025). The Michael Mason Prize: Development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine. Rheumatology, https://doi.org/10.1093/rheumatology/keaf413

Objectives Only 12% of people recommended fracture prevention medicines remain on treatment 1 year post fracture. The improving uptake of Fracture Prevention treatments (iFraP) intervention aims to improve shared decision-making (SDM) about, and upta... Read More about The Michael Mason Prize: Development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine.

Association of air pollution from a landfill site with changes in primary care consultation patterns (2025)
Journal Article
Jordan, K. P., Muller, S., Usman, M., Bailey, J., Burton, C., Lawton, S. A., Mallen, C. D., Mason, K. J., Wathall, S., & van der Windt, D. A. (2025). Association of air pollution from a landfill site with changes in primary care consultation patterns. Discover Environment, 3(1), Article 112. https://doi.org/10.1007/s44274-025-00324-5

Background: Waste landfill sites are associated with gaseous emissions and this air pollution can cause unpleasant smells (“malodour”). This causes concerns about its impact on the health of the local population. This study assessed change in general... Read More about Association of air pollution from a landfill site with changes in primary care consultation patterns.

Feasibility trial of a new digital training package to enhance primary care practitioners’ communication of clinical empathy and realistic optimism (2025)
Journal Article
Bishop, F., Howick, J., Vennik, J., Bostock, J., Little, P., Mallen, C., Morrison, L., Steele, M., Stuart, B., Hughes, S., Smith, K., Ratnapalan, M., Lyness, E., Dambha-Miller, H., Tiwari, R., Lockyer-Stevens, C., & Everitt, H. (in press). Feasibility trial of a new digital training package to enhance primary care practitioners’ communication of clinical empathy and realistic optimism. PloS one, 20(7), e0324649. https://doi.org/10.1371/journal.pone.0324649

Background
Patients can benefit when primary care practitioners communicate clinical empathy and optimism during consultations, but previous training interventions for practitioners are overly time-consuming and evidence on patient outcomes is limit... Read More about Feasibility trial of a new digital training package to enhance primary care practitioners’ communication of clinical empathy and realistic optimism.

Involving public contributors in decision aid development: reflections from the iFrap study (2025)
Presentation / Conference Contribution
Bullock, L., Bentley, I., Worrall, A., Haines, R., Jinks, C., Moult, A., Fleming, J., Clark, E., Nicholls, E., Leyland, S., Thomas, S., Iglesias-Urrutia, C., O’Neill, T., Mallen, C., & Paskins, Z. (2024, September). Involving public contributors in decision aid development: reflections from the iFrap study. Presented at International Conference on Communication in Healthcare, Zaragoza, Spain

Combining multiple methods to develop the iFraP osteoporosis shared decision-making intervention (2025)
Presentation / Conference Contribution
Paskins, Z., Bullock, L., Fleming, J., Clark, E., Leyland, S., Thomas, S., Gidlow, C., O'Neil, T., Iglesias-Urrutia, C., Hawarden, A., Manning, F., Protheroe, J., Lefroy, J., Ryan, S., Horne, R., Mallen, C., & Jinks, C. (2024, September). Combining multiple methods to develop the iFraP osteoporosis shared decision-making intervention. Presented at International Conference on Communication in Healthcare (ICCH 2024), ZarZagoza, Spain at the Residencia de Estudiantes Ramón Pignatelli Zaragoza

The role of clinician training to facilitate shared decision-making: findings from the iFraP study (2025)
Presentation / Conference Contribution
Bullock, L., Jinks, C., Lefroy, J., Protheroe, J., Dale, N., Ryan, S., Leyland, S., Thomas, S., Gidlow, C., Fleming, J., Clark, E., Horne, R., Iglesias-Urrutia, C., O’Neill, T., Mallen, C., & Paskins, Z. (2024, September). The role of clinician training to facilitate shared decision-making: findings from the iFraP study. Presented at International Conference on Communication in Healthcare, Zaragoza, Spain

Physiotherapy for the Management of Polymyalgia Rheumatica: Results From a UK Cross‐Sectional Survey (2025)
Journal Article
O'Brien, A. V., Muller, S., Liddle, J., Thomas, M. J., & Mallen, C. D. (2025). Physiotherapy for the Management of Polymyalgia Rheumatica: Results From a UK Cross‐Sectional Survey. Musculoskeletal Care, 23(3), Article e70155. https://doi.org/10.1002/msc.70155

Introduction: Polymyalgia rheumatica (PMR) international management guidelines advocate patient education and individualised exercises but lack evidence and physiotherapy practice for PMR is unknown. PMR is typically treated with glucocorticoids, but... Read More about Physiotherapy for the Management of Polymyalgia Rheumatica: Results From a UK Cross‐Sectional Survey.

Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review] (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Hughes, G., Marshall, E., Lawton, S. A., Wathall, S., Helliwell, T., Jowett, S., Avery, A. J., Knaggs, R., Hussain, B., Santer, M., Pincus, T., White, S., Sillitto, C., Jinks, C., & Mallen, C. D. (2025). Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review]. NIHR Open Research, 5(54), https://doi.org/10.3310/nihropenres.13961.1

Background
Addressing the need for evidence-based interventions to reduce opioid use for persistent pain, we developed the PROMPPT intervention (Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clini... Read More about Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review].