All Outputs (620)

Trends in the use of video consultation in general practice during COVID-19: impact of practice and country characteristics based on the international, cross-sectional PRICOV-19 study (2025)
Journal Article
Kirk, U. B., Pellin, M. D. L. C. G., Hoffmann, K., Stummer, F. O., Van Poel, E., Vestergaard, C. H., Holm, A., Tatsioni, A., Petrazzuoli, F., Neves, A. L., Bravo, R. G., Asenova, R., Mallen, C., Bojaj, G., Rochfort, A., Bussche, P. V., Collins, C., Willems, S., Bro, F., Rohrbasser, A., & Huibers, L. (2025). Trends in the use of video consultation in general practice during COVID-19: impact of practice and country characteristics based on the international, cross-sectional PRICOV-19 study. BMC Primary Care, 26(1), 13. https://doi.org/10.1186/s12875-025-02892-0

Background: The COVID-19 pandemic accelerated the use of telemedicine, specifically video consultations as they provide healthcare access in challenging situations where face-to-face encounters are not possible. Nevertheless, it remains largely unkno... Read More about Trends in the use of video consultation in general practice during COVID-19: impact of practice and country characteristics based on the international, cross-sectional PRICOV-19 study.

Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England (2025)
Journal Article
Lawton, S. A., Mallen, C., Chew-Graham, C., Kingstone, T., Muller, S., Lewis, S., Bajpai, R., & Helliwell, T. (2025). Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England. BMJ Open, 15(6), 1-7. https://doi.org/10.1136/bmjopen-2024-095040

To examine the number of patients screening positive for depression, while self-completing an automated check-in screen prior to a general practice consultation. A descriptive cross-sectional study. 10 general practices in the West Midlands, England.... Read More about Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England.

Process and feasibility of implementing guideline recommendations for the care of osteoarthritis in West Africa (2025)
Journal Article
Babatunde, O. O., Adetunji, O., Alonge, I., Owoyemi, T., Ayinmode, E., Ogunbanjo, A., White, S., Adebajo, A., Mallen, C., & Dziedzic, K. (2025). Process and feasibility of implementing guideline recommendations for the care of osteoarthritis in West Africa. BMJ Global Health, 10(6), Article e018714. https://doi.org/10.1136/bmjgh-2024-018714

To assess the feasibility of a guideline-informed model of care for osteoarthritis in primary healthcare and community pharmacy settings in the West African context. The 4-phase mixed-methods programme of research undertaken in Southwest Nigeria, Wes... Read More about Process and feasibility of implementing guideline recommendations for the care of osteoarthritis in West Africa.

392 Sterile Water Injections for Acute Pain Relief in Renal Colic: A Meta-Analysis of Randomised Controlled Trials (2025)
Presentation / Conference Contribution
Perros, I., Swift, C., Mallen, C., Sokhal, B. S., & Kitchen, M. (2025, March). 392 Sterile Water Injections for Acute Pain Relief in Renal Colic: A Meta-Analysis of Randomised Controlled Trials. Poster presented at ASiT Surgical Conference, Belfast, UK

Aim
Effective renal colic management relies on optimal pain relief. Each medication has its distinct side effects and contraindications. Sterile water injections (SWIs) have emerged as a potential alternative to standard treatment. This systematic r... Read More about 392 Sterile Water Injections for Acute Pain Relief in Renal Colic: A Meta-Analysis of Randomised Controlled Trials.

Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study (2025)
Journal Article
Hamad, N., Muller, S., Hider, S., Partington, R., Helliwell, T., Butt, H., Hay, C., & Mallen, C. (2025). Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study. Rheumatology Advances in Practice, 1-19. https://doi.org/10.1093/rap/rkaf060

Objectives
To investigate the anatomical locations of pain and stiffness in people with polymyalgia rheumatica (PMR) and how it compares to the general population.

Methods
739 people with PMR were invited to complete a postal survey at the time... Read More about Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study.

The Relative Effectiveness of Different Types and Modes of Delivery of Therapeutic Exercise on pain and physical function for People with Knee and/or Hip Osteoarthritis: A Systematic Review Update and Individual Participant Data Network Meta-analysis (2025)
Preprint / Working Paper
Bajpai, R., Nicolson, P., Holden, M., Hattle, M., Van Der Windt, D., Riley, R., van Middelkoop, M., Marshall, E., Corp, N., Harrison, S., Simkins, J., Hall, M., Healey, E., Zhang, W., Mallen, C., Bennell, K., Foster, N., Runhaar, J., Bierma-Zeinstra, S., & Quicke, J. (2025). The Relative Effectiveness of Different Types and Modes of Delivery of Therapeutic Exercise on pain and physical function for People with Knee and/or Hip Osteoarthritis: A Systematic Review Update and Individual Participant Data Network Meta-analysis

The study objective is to compare and rank the effectiveness of different types, and modes of delivery of therapeutic exercise on pain and physical function at <=3, 4-11, and >=12 months for people with knee and/or hip osteoarthritis in an IPD networ... Read More about The Relative Effectiveness of Different Types and Modes of Delivery of Therapeutic Exercise on pain and physical function for People with Knee and/or Hip Osteoarthritis: A Systematic Review Update and Individual Participant Data Network Meta-analysis.

Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial (2025)
Other
Thomas, M. J., Hughes, G., Cooke, K., Butler-Walley, S., Marshall, E., Bowyer, L., Wathall, S., Smith, J., Lawton, S. A., Brammar, J., Burnett, T., Drake, C., Foster, N. E., Hendry, G. J., Holden, M. A., Jaki, T., Joseph, R., Keenan, A.-M., Kigozi, J., Lewis, M., …Roddy, E. (2025). Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial

Plantar heel pain (PHP) is the most common soft tissue foot condition and impairs mobility, physical function, ability to work, and quality of life. Systematic reviews highlight a need for high-quality randomised controlled trials (RCTs) of exercises... Read More about Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial.

Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation (2025)
Journal Article
A Harrisson, S., Myers, H., Wynne Jones, G., Bajpai, R., Bratt, C., Burton, C., Harrison, R., Jowett, S., A Lawton, S., Saunders, B., J Beard, D., Bucknall, M., Chester, R., Heneghan, C., Huckfield, L., Lewis, M., D Mallen, C., Pincus, T., L Rees, J., Roddy, E., & A Van der Windt, D. (2025). Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation. BMJ Open, 15(5), https://doi.org/10.1136/bmjopen-2025-100501

Introduction: Musculoskeletal shoulder pain is a common reason for people to be treated in physiotherapy services, but diagnosis can be difficult and often does not guide treatment or predict outcome. People with shoulder pain cite a need for clear i... Read More about Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation.

Facilitators and barriers to smoking cessation after myocardial infarction (2025)
Journal Article
Lovatt, S., Chowdury, N., Mallen, C., & Cooke, A. (2025). Facilitators and barriers to smoking cessation after myocardial infarction. Practice Nursing, 36(5), 157-162. https://doi.org/10.12968/pnur.2025.0009

Smoking cessation is a key pillar of secondary prevention for patients who have experienced a cardiac event. This article summarises a literature review on smoking cessation after myocardial infarction, highlighting the implications for general pract... Read More about Facilitators and barriers to smoking cessation after myocardial infarction.

P102 Pain management and its variation by deprivation in patients with inflammatory arthritis: the PAIN PATH survey (2025)
Presentation / Conference Contribution
Scott, I. C., Daud, N., Hider, S., Paskins, Z., Twohig, H., Halliday, N., Mallen, C. D., Jordan, K. P., & Muller, S. (2025, April). P102 Pain management and its variation by deprivation in patients with inflammatory arthritis: the PAIN PATH survey. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England, UK

Background/Aims UK-based electronic health record studies show that many patients with inflammatory arthritis (IA) receive opioid and gabapentinoid prescriptions - particularly in areas of deprivation - despite little and no evidence for efficacy, re... Read More about P102 Pain management and its variation by deprivation in patients with inflammatory arthritis: the PAIN PATH survey.

OA19 The prevalence of fibromyalgia in people with inflammatory arthritis: an observational study in the Clinical Practice Research Datalink Aurum (2025)
Presentation / Conference Contribution
Adeniran, K., Partington, R., Bailey, J., Mallen, C. D., Muller, S., & Scott, I. C. (2025, April). OA19 The prevalence of fibromyalgia in people with inflammatory arthritis: an observational study in the Clinical Practice Research Datalink Aurum. Presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England

Background/Aims Fibromyalgia, a common condition characterised by chronic widespread pain/somatic symptoms, has substantial impacts on patients’ lives and healthcare use. Previous studies suggest it is far more common in inflammatory arthritis than t... Read More about OA19 The prevalence of fibromyalgia in people with inflammatory arthritis: an observational study in the Clinical Practice Research Datalink Aurum.

OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink (2025)
Presentation / Conference Contribution
Partington, R., Muller, S., Mallen, C. D., Mamas, M. A., Forrester, H., & Roddy, E. (2025, April). OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink. Presented at British Society for Rheumatology Annual Conference, Manchester Central Convention Complex, Manchester, England

Background/Aims Febuxostat is recommended as first line urate-lowering therapy (ULT) for gout in the UK. However, concerns were raised regarding its cardiovascular (CV) safety. Current guidance advises caution when using it in people with CV disease,... Read More about OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink.

P084 Implementing an osteoporosis shared decision-making intervention in Fracture Liaison Services: interview findings from the iFraP process evaluation (2025)
Presentation / Conference Contribution
Bullock, L., Cherrington, A., Clark, E. M., Fleming, J., Bentley, I., Nicholls, E., Webb, D., Smith, J., Lewis, S., Horne, R., O’Neill, T. W., Mallen, C. D., Jinks, C., & Paskins, Z. (2025, April). P084 Implementing an osteoporosis shared decision-making intervention in Fracture Liaison Services: interview findings from the iFraP process evaluation. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England, UK

Background/Aims High quality shared decision-making (SDM) conversations involve people with or at risk of osteoporosis and clinicians working together to reach decisions about care. The improving uptake of Fracture Prevention drug treatments (iFraP)... Read More about P084 Implementing an osteoporosis shared decision-making intervention in Fracture Liaison Services: interview findings from the iFraP process evaluation.

Reply. (2025)
Journal Article
Kaur, J., Nakafero, G., Abhishek, A., Mallen, C., Doherty, M., & Zhang, W. (2025). Reply. Arthritis Care & Research, 1-2. https://doi.org/10.1002/acr.25560

P055 Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case-control study in the Clinical Practice Research Datalink Aurum (2025)
Presentation / Conference Contribution
Scott, I. C., Daud, N., Bailey, J., Twohig, H., Hider, S., Mallen, C. D., Jordan, K. P., & Muller, S. (2025, April). P055 Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case-control study in the Clinical Practice Research Datalink Aurum. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England, UK

Background/Aims Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabapentinoids are associated w... Read More about P055 Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case-control study in the Clinical Practice Research Datalink Aurum.

Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care (2025)
Journal Article
Harrisson, S. A., Jinks, C., Cornwall, N., Woodcock, C., Dikomitis, L., Helliwell, T., Higginbottom, A., Lefroy, J., Knaggs, R., Pincus, T., Santar, M., Sillitto, C., Webb, M., White, S., Mallen, C. D., & Ashworth, J. (2025). Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care. Health Expectations, 28(3), Article e70264. https://doi.org/10.1111/hex.70264

Background: Stakeholder involvement is a core element of the Medical Research Council (MRC) framework for developing and evaluating complex interventions, but approaches to involve stakeholders are not well‐reported. We outline how stakeholders contr... Read More about Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care.

Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2025). Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study. Pilot and Feasibility Studies, 11(1), Article 53. https://doi.org/10.1186/s40814-025-01636-2

Background: Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence-based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore the... Read More about Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study.

001 PSYCHOLOGICAL AND PAIN RELATED COMORBIDITIES IN PEOPLE WITH OSTEOARTHRITIS IN EUROPE - EVIDENCE FROM THE ComOA STUDY (2025)
Presentation / Conference Contribution
Swain, S., Coupland, C., Thompson, W., Mallen, C., Alhambra, D. P., Englund, M., Bierma-Zeinstra, S., Doherty, M., & Zhang, W. (2025, April). 001 PSYCHOLOGICAL AND PAIN RELATED COMORBIDITIES IN PEOPLE WITH OSTEOARTHRITIS IN EUROPE - EVIDENCE FROM THE ComOA STUDY. Presented at 2025 OARSI World Congress on Osteoarthritis, Incheon, South Korea

A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children (2025)
Journal Article
Twohig, H., Franklin, L., Carroll, W., Corp, N., Jackson, E., Mallen, C., Ruan, B., Yapp, L., Van Der Windt, D., & Smith, J. (2025). A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children. Paediatric Respiratory Reviews, 1-37. https://doi.org/10.1016/j.prrv.2025.04.005

Background
Dry powder inhalers (DPIs) are a lower-carbon option than pressurised metered dose inhalers (pMDIs). However, DPIs require a forceful inhalation to achieve good lung deposition and there is uncertainty as to whether younger children can e... Read More about A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children.

Mixed methods evaluation of using the ‘EMPathicO’ communication skills e-learning in primary care: “<i>a super weapon to make the whole experience a bit better”</i> (2025)
Preprint / Working Paper
Teasdale, E., Dewar-Haggart, R., Pollet, S., Leydon, G. M., Everitt, H., Cross, N., Atherton, H., Becque, T., Bostock, J., Garfield, K., Herbert, A., Howick, J., Little, P., Mallen, C., Morrison, L., Nuttall, J., Ridd, M. J., Robnson, M. E., Stuart, B., Vennick, J., …Bishop, F. L. (2025). Mixed methods evaluation of using the ‘EMPathicO’ communication skills e-learning in primary care: “a super weapon to make the whole experience a bit better”

Objectives To examine primary care practitioners’ experiences and use of EMPathicO e-learning to enhance communication of clinical empathy and realistic optimism.

Design Mixed methods evaluation incorporating thematic analysis of qualitative inter... Read More about Mixed methods evaluation of using the ‘EMPathicO’ communication skills e-learning in primary care: “<i>a super weapon to make the whole experience a bit better”</i>.