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All Outputs (18)

Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion (2023)
Journal Article
Holland, D., Fryer, A. A., Stedman, M., Hanna, F. W. F., Duff, C. J., Green, L., …Wu, P. (2023). Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion. Diabetes Therapy, https://doi.org/10.1007/s13300-023-01482-6

Women are on average diagnosed with diabetes mellitus at later age than men but have higher mortality. As the diagnosis of diabetes mellitus is primarily based on HbA1c, the use of a non-specific reference range and cut point for diabetes mellitus th... Read More about Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion.

The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation (2023)
Journal Article
Holland, D., Heald, A. H., Hanna, F. F., Stedman, M., Wu, P., Sim, J., …Fryer, A. A. (2023). The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation. Diabetes Therapy, 14, 691-707. https://doi.org/10.1007/s13300-023-01380-x

INTRODUCTION: Studies show that the COVID-19 pandemic disproportionately affected people with diabetes and those from disadvantaged backgrounds. During the first 6 months of the UK lockdown,?>?6.6 M glycated haemoglobin (HbA1c) tests were missed. We... Read More about The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation.

Evaluation of thyroid function monitoring in people treated with lithium: Advice based on real‐world data (2023)
Journal Article
Duce, H. L., Duff, C. J., Zaidi, S., Parfitt, C., Heald, A. H., & Fryer, A. A. (2023). Evaluation of thyroid function monitoring in people treated with lithium: Advice based on real‐world data. Bipolar Disorders, 25(5), 402-409. https://doi.org/10.1111/bdi.13298

INTRODUCTION: Blood test monitoring is essential for management of lithium treatment and NICE guidance recommends 6-monthly serum testing of thyroid function. We examined conformity to these guidelines and impact of monitoring outside these intervals... Read More about Evaluation of thyroid function monitoring in people treated with lithium: Advice based on real‐world data.

Variability in Test Interval Is Linked to Glycated Haemoglobin (HbA1c) Trajectory over Time (2022)
Journal Article
Fryer, A. A., Holland, D., Stedman, M., Duff, C. J., Green, L., Scargill, J., …Heald, A. H. (2022). Variability in Test Interval Is Linked to Glycated Haemoglobin (HbA1c) Trajectory over Time. Journal of Diabetes Research, 2022, 1 - 11. https://doi.org/10.1155/2022/7093707

Aims. We previously showed that the glycated haemoglobin (HbA1c) testing frequency links to diabetes control. Here, we examine the effect of variability in test interval, adjusted for the frequency, on change in HbA1c (delta HbA1c). Materials & Metho... Read More about Variability in Test Interval Is Linked to Glycated Haemoglobin (HbA1c) Trajectory over Time.

Can we check serum lithium levels less often without compromising patient safety? (2021)
Journal Article
Heald, A. H., Holland, D., Stedman, M., Davies, M., Duff, C. J., Parfitt, C., …Fryer, A. A. (2021). Can we check serum lithium levels less often without compromising patient safety?. BJPsych Open, e18 - ?. https://doi.org/10.1192/bjo.2021.1027

BACKGROUND: Lithium is viewed as the first-line long-term treatment for prevention of relapse in people with bipolar disorder. AIMS: This study examined factors associated with the likelihood of maintaining serum lithium levels within the recomme... Read More about Can we check serum lithium levels less often without compromising patient safety?.

Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital (2021)
Journal Article
Hanna, F. W. F., Hancock, S., George, C., Clark, A., Sim, J., Issa, B. G., …Fryer, A. A. (2022). Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital. Journal of the Endocrine Society, 6(1), https://doi.org/10.1210/jendso/bvab180

Context: Adrenal incidentalomas (AIs) are increasingly being identified during unrelated imaging. Unlike AI clinical management, data on referral patterns in routine practice are lacking. Objective: This work aimed to identify factors associated with... Read More about Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital.

The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval (2021)
Journal Article
Heald, A., Holland, D., Stedman, M., Duff, C. J., Green, L., Scargill, J., …Fryer, A. A. (in press). The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval. Endocrine, https://doi.org/10.1530/endoabs.77.p64

Worldwide guidance advocates regular HbA1c testing for people with diabetes mellitus, usually 2-4/yr. We previously showed that HbA1c testing frequency is linked to outcome in terms of HbA1c control. Here we examine the effect of variability (standar... Read More about The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval.

Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis. (2021)
Journal Article
Holland, D., Heald, A. H., Stedman, M., Hanna, F., Wu, P., Duff, C., …Fryer, A. A. (2021). Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis. Journal of Clinical Pathology, 76(3), https://doi.org/10.1136/jclinpath-2021-207776

AIMS: The COVID-19 pandemic, and the focus on mitigating its effects, has disrupted diabetes healthcare services worldwide. We aimed to quantify the effect of the pandemic on diabetes diagnosis/management, using glycated haemoglobin (HbA1c) as surrog... Read More about Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis..

Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years. (2021)
Journal Article
Ward, R. J., Fryer, A. A., Hanna, F. W., Spencer, N., Mahmood, M., Wu, P., …Duff, C. J. (2021). Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years. International Journal of Clinical Practice, e14447 - ?. https://doi.org/10.1111/ijcp.14447

INTRODUCTION: Women with gestational diabetes (GDM) are at greatly increased risk of type 2 diabetes (T2DM). The UK guidance recommends screening for T2DM at around 6 weeks post-partum and annually thereafter. We evaluated conformity to this guidance... Read More about Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years..

Investigation of polycystic ovarian syndrome: variation in practice and impact on the speed of diagnosis (2021)
Journal Article
Karia, A. M., Duff, C. J., Heald, A. H., Britton, I., Fryer, A. A., & Wu, P. (2021). Investigation of polycystic ovarian syndrome: variation in practice and impact on the speed of diagnosis. Cardiovascular Endocrinology & Metabolism, 10(2), 120-124. https://doi.org/10.1097/xce.0000000000000245

Objective Accurate diagnosis of polycystic ovarian syndrome (PCOS) enables clinical interventions/cardiometabolic risk factor management. Diagnosis can take over 2 years and multiple clinician contacts. We examined patterns of PCOS-associated biochem... Read More about Investigation of polycystic ovarian syndrome: variation in practice and impact on the speed of diagnosis.

People with Type Diabetes Mellitus (T1DM) self-reported views on their own condition management reveal links to potentially improved outcomes and potential areas for service improvement (2020)
Journal Article
Stedman, M., Rea, R., Duff, C., Livingston, M., McLoughlin, K., Wong, L., …Heald, A. (2020). People with Type Diabetes Mellitus (T1DM) self-reported views on their own condition management reveal links to potentially improved outcomes and potential areas for service improvement. Diabetes Research and Clinical Practice, 170, Article 108479. https://doi.org/10.1016/j.diabres.2020.108479

Background The self-management of type 1 diabetes (T1DM) has moved forward in many areas over the last 40 years. Our study asked people with T1DM what is their experience of blood glucose (BG) monitoring day to day and how this influences decisions... Read More about People with Type Diabetes Mellitus (T1DM) self-reported views on their own condition management reveal links to potentially improved outcomes and potential areas for service improvement.

Self-Reported Views on Managing Type 1 Diabetes Mellitus (2020)
Journal Article
Stedman, M., Rea, R., Duff, C. J., Livingston, M., Brown, S., Grady, K., …Heald, A. H. (2021). Self-Reported Views on Managing Type 1 Diabetes Mellitus. Journal of Diabetes Science and Technology, 15(1), 198-200. https://doi.org/10.1177/1932296820937771

In the last 40 years, self–blood glucose monitoring (BGM) has revolutionized the treatment of type 1 diabetes mellitus (T1DM). Glaser et al1 reported that lack of understanding of and/or frustration with complexity of insulin dose calculations may co... Read More about Self-Reported Views on Managing Type 1 Diabetes Mellitus.

Cost of hospital treatment of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) compared to the non-diabetes population: a detailed economic evaluation (2020)
Journal Article
Stedman, M., Lunt, M., Davies, M., Livingston, M., Duff, C., Fryer, A., …Heald, A. (2020). Cost of hospital treatment of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) compared to the non-diabetes population: a detailed economic evaluation. BMJ Open, 10(5), https://doi.org/10.1136/bmjopen-2019-033231

OBJECTIVES: Other than age, diabetes is the largest contributor to overall healthcare costs and reduced life expectancy in Europe. This paper aims to more exactly quantify the net impact of diabetes on different aspects of healthcare provision in hos... Read More about Cost of hospital treatment of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) compared to the non-diabetes population: a detailed economic evaluation.

Applying Parkes Grid Method to Evaluate Impact of Variation in Blood Glucose Monitoring (BGM) Strip Accuracy Performance in Type 1 Diabetes Highlights the Potential for Amplification of Imprecision With Less Accurate BGM Strips (2020)
Journal Article
Stedman, M., Rea, R., Duff, C. J., Livingston, M., Moreno, G., Gadsby, R., …Heald, A. H. (2021). Applying Parkes Grid Method to Evaluate Impact of Variation in Blood Glucose Monitoring (BGM) Strip Accuracy Performance in Type 1 Diabetes Highlights the Potential for Amplification of Imprecision With Less Accurate BGM Strips. Journal of Diabetes Science and Technology, 15(1), 76-81. https://doi.org/10.1177/1932296820905880

The National Health Service spends £170 million on blood glucose monitoring (BGM) strips each year and there are pressures to use cheaper less accurate strips. Technology is also being used to increase test frequency with less focus on accuracy. Pre... Read More about Applying Parkes Grid Method to Evaluate Impact of Variation in Blood Glucose Monitoring (BGM) Strip Accuracy Performance in Type 1 Diabetes Highlights the Potential for Amplification of Imprecision With Less Accurate BGM Strips.

Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice (2019)
Journal Article
Heald, A. H., Palit, T., Livingston, M., Duff, C., & Fryer, A. (2019). Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice. International Journal of Clinical Practice, https://doi.org/10.1111/IJCP.13302

The above article from International Journal of Clinical Practice, published online on 7th December 2018 in Wiley Online Library (http://wileyonlinelibrary.com) has been withdrawn by agreement between the authors, the journal Editor in Chief, Leslie... Read More about Screening for thyroid disease in patients with type 2 diabetes mellitus: An evaluation of current practice.