All Outputs (32)

Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells (2018)
Presentation / Conference Contribution
Bountali, K., Maarabouni, M., & Tonge, D. Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells. Presented at 25th Biennial Congress of the European Association for Cancer Research

Abstract
Introduction Of the total human DNA only 1.2% o codes for proteins, with the rest only being transcribed into regulatory RNA, known as non-coding RNA. Long non-coding RNAs (lncRNAs) are non-coding RNAs that have no or limited protein-coding... Read More about Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells.

What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme (2016)
Journal Article
Tonge, D., & Gant, T. (2016). What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme. BMC Molecular Biology, https://doi.org/10.1186/s12867-016-0057-9

Background
MicroRNAs (miRNAs) are short non-protein-coding RNA species that have a regulatory function in modulating protein translation and degradation of specific mRNAs. MicroRNAs are estimated to target approximately 60 % of all human mRNAs and a... Read More about What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme.

Global miRNA profiling for biomarker discovery – What is normal? (2014)
Journal Article
Tonge, D., & Gant, T. (2014). Global miRNA profiling for biomarker discovery – What is normal?. Toxicology Letters, 229, S22. https://doi.org/10.1016/j.toxlet.2014.06.112

The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics (2014)
Journal Article
Tonge, D., Pearson, M., & Jones, S. (2014). The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics. Osteoarthritis and Cartilage, 22(5), 609-621. https://doi.org/10.1016/j.joca.2014.03.004

Amplicon -based Metagenomic Analysis of Mixed Fungal Samples using Proton Release Amplicon Sequencing (2014)
Journal Article
Tonge, D., Pashley, C., & Gant, T. (2014). Amplicon -based Metagenomic Analysis of Mixed Fungal Samples using Proton Release Amplicon Sequencing. PloS one, https://doi.org/10.1371/journal.pone.0093849

Next generation sequencing technology has revolutionised microbiology by allowing concurrent analysis of whole microbial communities. Here we developed and verified similar methods for the analysis of fungal communities using a proton release sequenc... Read More about Amplicon -based Metagenomic Analysis of Mixed Fungal Samples using Proton Release Amplicon Sequencing.

Evidence of changes to skeletal muscle contractile properties during the initiation of disease in the ageing guinea pig model of osteoarthritis (2013)
Journal Article
Tonge, D. P., Bardsley, R. G., Parr, T., Maciewicz, R. A., & Jones, S. W. (2013). Evidence of changes to skeletal muscle contractile properties during the initiation of disease in the ageing guinea pig model of osteoarthritis. Longevity and Healthspan, 2(1), https://doi.org/10.1186/2046-2395-2-15

Evidence based housekeeping gene selection for microRNA-sequencing (miRNA-seq) studies (2013)
Journal Article
Tonge, D. P., & Gant, T. W. (2013). Evidence based housekeeping gene selection for microRNA-sequencing (miRNA-seq) studies. Journal of Toxicology Research, 2(5), 328. https://doi.org/10.1039/c3tx50034a

The role of microRNAs in the pathogenesis of MMPi-induced skin fibrodysplasia (2013)
Journal Article
Tonge, D. P., Tugwood, J. D., Kelsall, J., & Gant, T. W. (2013). The role of microRNAs in the pathogenesis of MMPi-induced skin fibrodysplasia. BMC Genomics, 14(1), 338. https://doi.org/10.1186/1471-2164-14-338

The application of Next Generation Sequencing to the detection and analysis of miRNAs (2012)
Journal Article
Tonge, D. P., Tugwood, J., & Gant, T. (2012). The application of Next Generation Sequencing to the detection and analysis of miRNAs. Toxicology Letters, 211, S28. https://doi.org/10.1016/j.toxlet.2012.03.125

Characterisation of the sarcomeric myosin heavy chain multigene family in the laboratory guinea pig (2010)
Journal Article
Tonge, D. P., Jones, S. W., Bardsley, R. G., & Parr, T. (2010). Characterisation of the sarcomeric myosin heavy chain multigene family in the laboratory guinea pig. BMC Molecular Biology, 11(1), 52. https://doi.org/10.1186/1471-2199-11-52

β2-Adrenergic agonist-induced hypertrophy of the quadriceps skeletal muscle does not modulate disease severity in the rodent meniscectomy model of osteoarthritis (2010)
Journal Article
Tonge, D., Jones, S., Parr, T., Bardsley, R., Doherty, M., & Maciewicz, R. (2010). β2-Adrenergic agonist-induced hypertrophy of the quadriceps skeletal muscle does not modulate disease severity in the rodent meniscectomy model of osteoarthritis. Osteoarthritis and Cartilage, 18(4), 555-562. https://doi.org/10.1016/j.joca.2009.11.014

Multi-Method Characterisation of the Human Circulating Microbiome
Journal Article
Whittle, E., Leonard, M., Harrison, R., Gant, T., & Tonge, D. Multi-Method Characterisation of the Human Circulating Microbiome. arXiv, https://doi.org/10.1101/359760