All Outputs (177)

Type 2 diabetes, metabolic health, and the development of frozen shoulder: a cohort study in UK electronic health records (2025)
Journal Article
Dyer, B. P., Burton, C., Rathod-Mistry, T., Blagojevic-Bucknall, M., & van der Windt, D. A. (2025). Type 2 diabetes, metabolic health, and the development of frozen shoulder: a cohort study in UK electronic health records. BMC Musculoskeletal Disorders, 26(1), Article 471. https://doi.org/10.1186/s12891-025-08672-2

Objective: Estimate the effect of type 2 diabetes on the development of frozen shoulder and investigate whether the effect is mediated by other metabolic factors. Methods: Primary care medical record-based cohort study containing 43,977 people newly... Read More about Type 2 diabetes, metabolic health, and the development of frozen shoulder: a cohort study in UK electronic health records.

Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation (2025)
Journal Article
A Harrisson, S., Myers, H., Wynne Jones, G., Bajpai, R., Bratt, C., Burton, C., Harrison, R., Jowett, S., A Lawton, S., Saunders, B., J Beard, D., Bucknall, M., Chester, R., Heneghan, C., Huckfield, L., Lewis, M., D Mallen, C., Pincus, T., L Rees, J., Roddy, E., & A Van der Windt, D. (2025). Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation. BMJ Open, 15(5), https://doi.org/10.1136/bmjopen-2025-100501

Introduction: Musculoskeletal shoulder pain is a common reason for people to be treated in physiotherapy services, but diagnosis can be difficult and often does not guide treatment or predict outcome. People with shoulder pain cite a need for clear i... Read More about Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation.

A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children (2025)
Journal Article
Twohig, H., Franklin, L., Carroll, W., Corp, N., Jackson, E., Mallen, C., Ruan, B., Yapp, L., Van Der Windt, D., & Smith, J. (2025). A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children. Paediatric Respiratory Reviews, 1-37. https://doi.org/10.1016/j.prrv.2025.04.005

Background
Dry powder inhalers (DPIs) are a lower-carbon option than pressurised metered dose inhalers (pMDIs). However, DPIs require a forceful inhalation to achieve good lung deposition and there is uncertainty as to whether younger children can e... Read More about A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children.

The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs (2025)
Journal Article
Zhao, S. S., Harrison, S. R., Thompson, B., Yates, M., Eddison, J., Chan, A., Clarke, N., Corp, N., Davis, C., Felix, L., Flora, K., Gregory, W. J., Jones, G. T., Lamb, C. A., Marzo-Ortega, H., Murphy, D. J., Petrushkin, H., Sandhu, V., Sengupta, R., Siebert, S., …Gaffney, K. (2025). The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs. Rheumatology, Article keaf089. https://doi.org/10.1093/rheumatology/keaf089

Executive Summary: The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs (2025)
Journal Article
Zhao, S. S., Harrison, S. R., Thompson, B., Yates, M., Eddison, J., Chan, A., Clarke, N., Corp, N., Davis, C., Felix, L., Flora, K., Gregory, W. J., Jones, G. T., Lamb, C. A., Marzo-Ortega, H., Murphy, D. J., Petrushkin, H., Sandhu, V., Sengupta, R., Siebert, S., …Gaffney, K. (2025). Executive Summary: The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs. Rheumatology, Article keaf090. https://doi.org/10.1093/rheumatology/keaf090

The British Society for Rheumatology guideline for the management of foot health in inflammatory arthritis (2025)
Journal Article
Chapman, L. S., Backhouse, M., Corp, N., van der Windt, D., Bearne, L., Cherry, L., Cleary, G., Davey, J., Ferguson, R., Helliwell, P., Lomax, A., McKeeman, H., Rawlings, A. A., Rees, R., Rooney, R., Ryan, S., Sanders, L., Siddle, H. J., Varley, S., Warburton, L., …Roddy, E. (2025). The British Society for Rheumatology guideline for the management of foot health in inflammatory arthritis. Rheumatology, 1-14. https://doi.org/10.1093/rheumatology/keaf071

Executive Summary: The British Society for Rheumatology guideline for the management of foot health in inflammatory arthritis (2025)
Journal Article
Chapman, L. S., Backhouse, M., Corp, N., van der Windt, D., Bearne, L., Cherry, L., Cleary, G., Davey, J., Ferguson, R., Helliwell, P., Lomax, A., McKeeman, H., Rawlings, A. A., Rees, R., Rooney, R., Ryan, S., Sanders, L., Siddle, H. J., Varley, S., Warburton, L., …Roddy, E. (2025). Executive Summary: The British Society for Rheumatology guideline for the management of foot health in inflammatory arthritis. Rheumatology, 1-8. https://doi.org/10.1093/rheumatology/keaf072

Are clinical decision support systems seen as helpful to First Contact Practitioners (FCPs) working in musculoskeletal health? (2024)
Journal Article
Salt, E., Khalid, M., Van Der Windt, D., & Hill, J. (2025). Are clinical decision support systems seen as helpful to First Contact Practitioners (FCPs) working in musculoskeletal health?. Physiotherapy (Elsevier), 126, Article 101445. https://doi.org/10.1016/j.physio.2024.101445

Background There is increasing burden on musculoskeletal (MSK) First Contact Practitioners (FCPs) working in primary care. One possible solution is to use digital technologies such as clinical decision support syste... Read More about Are clinical decision support systems seen as helpful to First Contact Practitioners (FCPs) working in musculoskeletal health?.

Risk factors for shoulder pain and stiffness in adults aged 44 and older: an 11-year longitudinal population-based study (2024)
Journal Article
Lahti, V., Ibounig, T., Rämö, L., Härkänen, T., Shiri, R., van der Windt, D., Järvinen, T., Taimela, S., & Heliövaara, M. (2024). Risk factors for shoulder pain and stiffness in adults aged 44 and older: an 11-year longitudinal population-based study. Scandinavian Journal of Rheumatology, 1-7. https://doi.org/10.1080/03009742.2024.2420443

Objective
We conducted a longitudinal observational study over 11 years to identify the risk factors for developing shoulder pain, stiffness, or both.

Method
The study population (n = 1645) was identified from Health 2000 Survey, a nationally re... Read More about Risk factors for shoulder pain and stiffness in adults aged 44 and older: an 11-year longitudinal population-based study.

Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project) (2024)
Journal Article
Granviken, F., Meisingset, I., Bach, K., Bones, A. F., Simpson, M. R., Hill, J. C., van der Windt, D. A., & Vasseljen, O. (2024). Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project). PAIN, https://doi.org/10.1097/j.pain.0000000000003456

We developed the SupportPrim PT clinical decision support system (CDSS) using the artificial intelligence method case-based reasoning to support personalised musculoskeletal pain management. The aim of this study was to evaluate the effectiveness of... Read More about Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project).

Patient preferences for conservative treatment of shoulder pain: a discrete choice experiment (2024)
Journal Article
Versloot, A. H. C., Veldwijk, J., Ottenheijm, R. P. G., de Graaf, M., van der Windt, D. A., Koes, B. W., Runhaar, J., & Schiphof, D. (2024). Patient preferences for conservative treatment of shoulder pain: a discrete choice experiment. Family Practice, https://doi.org/10.1093/fampra/cmae050

Shoulder pain is common amongst adults, but little is known about patients' preferences. The aim of this study was to determine patients' preferences for treatment options offered for shoulder pain in primary care. A discrete choice experiment was us... Read More about Patient preferences for conservative treatment of shoulder pain: a discrete choice experiment.

Are patients with newly diagnosed frozen shoulder more likely to be diagnosed with type 2 diabetes? A cohort study in UK electronic health records (2024)
Journal Article
Dyer, B. P., Burton, C., Rathod‐Mistry, T., Blagojevic‐Bucknall, M., & van der Windt, D. A. (2024). Are patients with newly diagnosed frozen shoulder more likely to be diagnosed with type 2 diabetes? A cohort study in UK electronic health records. Diabetes, Obesity and Metabolism, https://doi.org/10.1111/dom.15965

Aim: To estimate the association between newly diagnosed frozen shoulder and a subsequent diagnosis of type 2 diabetes in primary care. Methods: We conducted an age‐, gender‐ and practice‐matched cohort study in UK primary care electronic medical rec... Read More about Are patients with newly diagnosed frozen shoulder more likely to be diagnosed with type 2 diabetes? A cohort study in UK electronic health records.

Individual participant data meta‐analysis to examine linear or non‐linear treatment‐covariate interactions at multiple time‐points for a continuous outcome (2024)
Journal Article
Hattle, M., Ensor, J., Scandrett, K., van Middelkoop, M., van der Windt, D. A., Holden, M. A., & Riley, R. D. (2024). Individual participant data meta‐analysis to examine linear or non‐linear treatment‐covariate interactions at multiple time‐points for a continuous outcome. Research Synthesis Methods, https://doi.org/10.1002/jrsm.1750

Individual participant data (IPD) meta‐analysis projects obtain, harmonise, and synthesise original data from multiple studies. Many IPD meta‐analyses of randomised trials are initiated to identify treatment effect modifiers at the individual level,... Read More about Individual participant data meta‐analysis to examine linear or non‐linear treatment‐covariate interactions at multiple time‐points for a continuous outcome.

Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT) (2024)
Journal Article
Farooq, S., Hattle, M., Kingstone, T., Ajnakina, O., Dazzan, P., Demjaha, A., Murray, R. M., Di Forti, M., Jones, P. B., Doody, G. A., Shiers, D., Andrews, G., Milner, A., Nettis, M. A., Lawrence, A. J., van der Windt, D. A., & Riley, R. D. (2024). Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT). British Journal of Psychiatry, 1-10. https://doi.org/10.1192/bjp.2024.101

Background
A clinical tool to estimate the risk of treatment-resistant schizophrenia (TRS) in people with first-episode psychosis (FEP) would inform early detection of TRS and overcome the delay of up to 5 years in starting TRS medication.

Aims... Read More about Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT).

Stratified health care for low back pain using the STarT Back approach: Holy Grail or doomed to fail? (2024)
Journal Article
Croft, P., Hill, J. C., Foster, N. E., Dunn, K. M., & van der Windt, D. A. (2024). Stratified health care for low back pain using the STarT Back approach: Holy Grail or doomed to fail?. PAIN, https://doi.org/10.1097/j.pain.0000000000003319

There have been at least 7 separate randomised controlled trials published between 2011 and 2023 that have examined primary care for nonspecific low back pain informed by the STarT Back approach to stratified care based on risk prediction, compared w... Read More about Stratified health care for low back pain using the STarT Back approach: Holy Grail or doomed to fail?.

Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare (2024)
Journal Article
Archer, L., Peat, G., Snell, K. I. E., Hill, J. C., Dunn, K. M., Foster, N. E., Bishop, A., van der Windt, D., & Wynne-Jones, G. (2024). Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare. Journal of Occupational Rehabilitation, https://doi.org/10.1007/s10926-024-10223-w

Purpose
To develop and validate prediction models for the risk of future work absence and level of presenteeism, in adults seeking primary healthcare with musculoskeletal disorders (MSD).

Methods
Six studies from the West-Midlands/Northwest regi... Read More about Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare.

Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review] (2024)
Journal Article
Twohig, H., Bajpai, R., Corp, N., Faux-Nightingale, A., Mallen, C., Robinson, T., Somayajula, G., van-Der-Windt, D., Welsh, V., & Burton, C. (2024). Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review]. NIHR Open Research, 4(22), https://doi.org/10.3310/nihropenres.13549.1

Background
Children and young people (CYP) may experience prolonged symptoms following COVID-19, commonly termed ‘Long-COVID’. The characteristics of Long-COVID in CYP are unclear, as are the sequalae of acute COVID-19. We aimed to systematically sy... Read More about Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review].

Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults. (2024)
Journal Article
Archer, L., L, A., Relton, S. D., SD, R., Akbari, A., A, A., Best, K., K, B., Bucknall, M., M, B., Conroy, S., S, C., Hattle, M., M, H., Hollinghurst, J., J, H., Humphrey, S., S, H., Lyons, R. A., RA, L., …investigators, T. E. (2024). Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults. Age and ageing, 53(3), Article afae057. https://doi.org/10.1093/ageing/afae057

Falls are common in older adults and can devastate personal independence through injury such as fracture and fear of future falls. Methods to identify people for falls prevention interventions are currently limited, with high risks of bias in publish... Read More about Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults..

Prognostic factors for liver, blood and kidney adverse events from glucocorticoid sparing immune-suppressing drugs in immune-mediated inflammatory diseases: a prognostic systematic review (2024)
Journal Article
Leaviss, J., Carroll, C., Essat, M., van der Windt, D., J Grainge, M., Card, T., Riley, R., & Abhishek, A. (2024). Prognostic factors for liver, blood and kidney adverse events from glucocorticoid sparing immune-suppressing drugs in immune-mediated inflammatory diseases: a prognostic systematic review. RMD Open, 10(1), Article e003588. https://doi.org/10.1136/rmdopen-2023-003588

Background Immune-suppressing drugs can cause liver, kidney or blood toxicity. Prognostic factors for these adverse-events are poorly understood.

Purpose To ascertain prognostic factors associated with liver, blood or kidney adverse-events in peop... Read More about Prognostic factors for liver, blood and kidney adverse events from glucocorticoid sparing immune-suppressing drugs in immune-mediated inflammatory diseases: a prognostic systematic review.

Concordance of shoulder symptoms and imaging findings: a protocol for the Finnish Imaging of Shoulder (FIMAGE) study. (2023)
Journal Article
T, I., R, B., N, S., L, R., P, T., S, R., S, K., T, H., H, R., T, C., M, P., T, J., & investigators, F. (2023). Concordance of shoulder symptoms and imaging findings: a protocol for the Finnish Imaging of Shoulder (FIMAGE) study. BMJ Open, 13, Article e074457. https://doi.org/10.1136/bmjopen-2023-074457

Introduction Shoulder pain is a substantial medical and socioeconomic problem in most societies, affecting the ability to work or carry out leisure time activities as well as subsequently influencing physical and psychological well-being. According t... Read More about Concordance of shoulder symptoms and imaging findings: a protocol for the Finnish Imaging of Shoulder (FIMAGE) study..