All Outputs (4)

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists (2014)
Journal Article
McCoull, W., Barton, P., Brown, A. J., Bowker, S. S., Cameron, J., Clarke, D. S., …Morgan, D. (2014). Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. Journal of Medicinal Chemistry, 57(14), 6128 - 6140

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identif... Read More about Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.

Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice (2014)
Journal Article
Bake, T., Murphy, M., Morgan, D., & Mercer, J. (2014). Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice. Appetite, 77, 60 - 71. https://doi.org/10.1016/j.appet.2014.02.020

Male C57BL/6 mice fed ad libitum on control diet but allowed access to a palatable high fat diet (HFD) for 2?h a day during the mid-dark phase rapidly adapt their feeding behaviour and can consume nearly 80% of their daily caloric intake during this... Read More about Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice.

Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension (2014)
Journal Article
Harris, L. E., Morgan, D. G., & Balthasar, N. (2014). Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension. Physiological Reports, 2(3), e00240-?. https://doi.org/10.1002/phy2.240

Growth hormone secretagogue receptor (GHS-R) signaling has been associated with growth hormone release, increases in food intake and pleiotropic cardiovascular effects. Recent data demonstrated that acute GHS-R antagonism leads to increases in mean a... Read More about Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension.

Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat (2014)
Journal Article
Bake, T., Morgan, D., & Mercer, J. (2014). Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat. Physiology and Behavior, 128, 70-79. https://doi.org/10.1016/j.physbeh.2014.01.018

Providing rats and mice with access to palatable high fat diets for a short period each day induces the consumption of substantial binge-like meals. Temporal food intake structure (assessed using the TSE PhenoMaster/LabMaster system) and metabolic ou... Read More about Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat.