Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40

Waring, Michael J.; Baker, David J.; Bennett, Stuart N.L.; Dossetter, Alexander G.; Fenwick, Mark; Garcia, Rob; Georgsson, Jennie; Groombridge, Sam D.; Loxham, Susan; MacFau, Philip A.; Maskill, Katie G.; Morgan, David; Morrell, Jenny; Pointon, Helen; Robb, Graeme R.; David M.  Smith; Stokesa, Stephen; Wilkinson, Gary

doi:10.1039/C5MD00037H

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Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40 (2015)
Journal Article
Waring, M. J., Baker, D. J., Bennett, S. N., Dossetter, A. G., Fenwick, M., Garcia, R., Georgsson, J., Groombridge, S. D., Loxham, S., MacFau, P. A., Maskill, K. G., Morgan, D., Morrell, J., Pointon, H., Robb, G. R., David M. Smith, Stokesa, S., & Wilkinson, G. (2015). Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40. MedChemComm, 2015(6), 1024-1029. https://doi.org/10.1039/C5MD00037H

A series of 2-(pyridinyl)pyrimidines were identified as potent GPR40 antagonists. Despite significant challenges related to improving the combination of potency and lipophilicity within the series, the compounds were optimised to identify a suitable... Read More about Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40.