Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy

Jenkins, SI; Pickard, MR; Khong, M; Smith, HL; Mann, CL; Emes, RD; Chari, DM

doi:10.1021/cn400167n

All Outputs (7)

A multicellular, neuro-mimetic model to study nanoparticle uptake in cells of the central nervous system (2014)
Journal Article
Fernandes, A. R., & Chari, D. M. A multicellular, neuro-mimetic model to study nanoparticle uptake in cells of the central nervous system. Integrative Biology, 6(9), 855-861. https://doi.org/10.1039/c4ib00085d

How do corticosteroids influence myelin genesis in the central nervous system? (2014)
Journal Article
Chari, D. M. (2014). How do corticosteroids influence myelin genesis in the central nervous system?. Neural Regeneration Research, 9(9), 909. https://doi.org/10.4103/1673-5374.133131

Clinical use of corticosteroid (CS) therapy and links with adverse neurological effects
CS therapy is widely used in clinical practice worldwide, with administration of high and multiple doses prescribed for a range of disease and injury. Notably, C... Read More about How do corticosteroids influence myelin genesis in the central nervous system?.

Developing the Keele Medical Research Pathway: Challenges For a Young Medical School (2014)
Journal Article
Chari, D. M., & Hider, S. (2014). Developing the Keele Medical Research Pathway: Challenges For a Young Medical School. Midlands Medicine, 27(3), 140

Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges (2014)
Journal Article
Jenkins, S., Yiu, H., Rosseinsky, M., & Chari, D. (2014). Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges. Molecular and Cellular Therapies, https://doi.org/10.1186/2052-8426-2-23

Oligodendrocyte precursor cells (OPCs) have shown high promise as a transplant population to promote regeneration in the central nervous system, specifically, for the production of myelin - the protective sheath around nerve fibers. While clinical tr... Read More about Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges.

Spinal cord injury model (2014)
Journal Article
Chari, D. M. Spinal cord injury model. Alternatives to laboratory animals : ATLA, 42(1), 3

An in vitro spinal cord injury model to screen neuroregenerative materials (2014)
Journal Article
Weightman, A. P., Pickard, M. R., Yang, Y., & Chari, D. M. (2014). An in vitro spinal cord injury model to screen neuroregenerative materials. Biomaterials, 35(12), 3756-3765. https://doi.org/10.1016/j.biomaterials.2014.01.022

Implantable ‘structural bridges’ based on nanofabricated polymer scaffolds have great promise to aid spinal cord regeneration. Their development (optimal formulations, surface functionalizations, safety, topographical influences and degradation profi... Read More about An in vitro spinal cord injury model to screen neuroregenerative materials.

Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy (2014)
Journal Article
Jenkins, S., Pickard, M., Khong, M., Smith, H., Mann, C., Emes, R., & Chari, D. (2014). Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy. ACS chemical neuroscience, 51 -63. https://doi.org/10.1021/cn400167n

Corticosteroid (CS) therapy is used widely in the treatment of a range of pathologies, but can delay production of myelin, the insulating sheath around central nervous system nerve fibers. The cellular targets of CS action are not fully understood, t... Read More about Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy.