Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection
(2023)
Journal Article
Fraser-Pitt, D., Mercer, D. K., Francis, M., Toledo-Aparicio, D., Smith, D. W., & O'Neil, D. A. (2023). Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection. Biochemical and Biophysical Research Communications, 677, 168-181. https://doi.org/10.1016/j.bbrc.2023.08.021
Transient blockade of glycine decarboxylase (GLDC) can restrict de novo pyrimidine synthesis, which is a well-described strategy for enhancing the host interferon response to viral infection and a target pathway for some licenced anti-inflammatory th... Read More about Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection.