All Outputs (225)

A genome-wide association analysis reveals new pathogenic pathways in gout. (2024)
Journal Article
Major, T. J., Takei, R., Matsuo, H., Leask, M. P., Sumpter, N. A., Topless, R. K., …Merriman, T. R. (in press). A genome-wide association analysis reveals new pathogenic pathways in gout. Nature Genetics, https://doi.org/10.1038/s41588-024-01921-5

Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of go... Read More about A genome-wide association analysis reveals new pathogenic pathways in gout..

Pain Reduction With Oral Methotrexate in Knee Osteoarthritis (2024)
Journal Article
Kingsbury, S. R., Tharmanathan, P., Keding, A., Watt, F. E., Scott, D. L., Roddy, E., …Conaghan, P. G. (in press). Pain Reduction With Oral Methotrexate in Knee Osteoarthritis. Annals of Internal Medicine, 177(9), https://doi.org/10.7326/m24-0303

Effectiveness of footwear and foot orthoses in reducing medial metatarsophalangeal joint pressure in women with hallux valgus (2024)
Journal Article
Roddy, E., Menz, H., Lim, P., Hurn, S., Mickle, K., Buldt, A., …Munteanu, S. (2024). Effectiveness of footwear and foot orthoses in reducing medial metatarsophalangeal joint pressure in women with hallux valgus. Gait and Posture, 111, 156-161. https://doi.org/10.1016/j.gaitpost.2024.04.021

Background
Hallux valgus is a common condition where the subluxation of the first metatarsophalangeal joint and lateral deviation of the hallux at the interphalangeal joint creates difficulty with footwear fit. Footwear and foot orthoses are commonl... Read More about Effectiveness of footwear and foot orthoses in reducing medial metatarsophalangeal joint pressure in women with hallux valgus.

Effectiveness of footwear and foot orthoses in reducing medial metatarsophangeal joint pressure in women with hallux valgus (2024)
Journal Article
Menz, H. B., Lim, P. Q., Hurn, S. E., Mickle, K. J., Buldt, A. K., Cotchett, M. P., …Munteanu, S. E. (in press). Effectiveness of footwear and foot orthoses in reducing medial metatarsophangeal joint pressure in women with hallux valgus. Gait & Posture, 111, 156-161. https://doi.org/10.1016/j.gaitpost.2024.04.021

Background
Hallux valgus is a common condition where the subluxation of the first metatarsophalangeal joint and lateral deviation of the hallux at the interphalangeal joint creates difficulty with footwear fit. Fo... Read More about Effectiveness of footwear and foot orthoses in reducing medial metatarsophangeal joint pressure in women with hallux valgus.

Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study (2024)
Journal Article
Bajpai, R., Partington, R., Muller, S., Forrester, H., Mallen, C. D., Clarson, L., …Roddy, E. (2024). Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study. Rheumatology, Article keae229. https://doi.org/10.1093/rheumatology/keae229

Objectives
Colchicine is commonly used to prevent flares when starting urate-lowering therapy for gout. Patients with gout are frequently concurrently prescribed other medications (such as statins) that may interact with colchicine, increasing the r... Read More about Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study.

How common are side effects of treatment to prevent gout flares when starting allopurinol? (2024)
Journal Article
Saul, H., Deeney, B., Swaithes, L., & Roddy, E. (in press). How common are side effects of treatment to prevent gout flares when starting allopurinol?. BMJ, 384, Article q514. https://doi.org/10.1136/bmj.q514

The studyRoddy E, Bajpai R, Forrester H, et al. Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. 2023;82:1618-25.To re... Read More about How common are side effects of treatment to prevent gout flares when starting allopurinol?.

Health Literacy and Gout Characteristics in a Primary Care Cohort (2024)
Journal Article
Watson, L., Protheroe, J., Mallen, C., Muller, S., & Roddy, E. (2024). Health Literacy and Gout Characteristics in a Primary Care Cohort. Rheumatology Advances in Practice, 8(2), Article rkae034. https://doi.org/10.1093/rap/rkae034

Objectives
To examine the cross-sectional association between health literacy and gout characteristics.

Methods
In a primary care cohort of adults living with gout, the prevalence of poor health literacy was defined using the Single-Item Literac... Read More about Health Literacy and Gout Characteristics in a Primary Care Cohort.

Diagnosis and management of gout: are the British Society for Rheumatology and National Institute for Health and Care Excellence guidelines both needed? (2024)
Journal Article
Roddy, E., Jordan, K. M., & Giles, I. (in press). Diagnosis and management of gout: are the British Society for Rheumatology and National Institute for Health and Care Excellence guidelines both needed?. Rheumatology Advances in Practice, 8(1), Article rkae007. https://doi.org/10.1093/rap/rkae007

The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis (2023)
Journal Article
Kigozi, J., Oppong, R., Paskins, Z., Bromley, K., Lewis, M., Hughes, G., …Roddy, E. (2023). The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis. Rheumatology, https://doi.org/10.1093/rheumatology/kead659

Objectives. Evidence for the comparative cost-effectiveness of intra-articular corticosteroid injection in people with hip osteoarthritis (OA) remains unclear. This study investigated the cost-effectiveness of best current treatment (BCT) comprising... Read More about The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis.

Ankle osteoarthritis: an online survey of current treatment practices of UK-based podiatrists and physiotherapists (2023)
Journal Article
Callaghan, M. J., Gala, J. P., & Roddy, E. (in press). Ankle osteoarthritis: an online survey of current treatment practices of UK-based podiatrists and physiotherapists. Journal of Foot and Ankle Research, 16(1), Article 89. https://doi.org/10.1186/s13047-023-00683-3

Background: Patients with painful ankle osteoarthritis (OA) have a mixed experience of non-surgical management which they may attribute to a lack of guidance for clinicians on usual care treatment. Therefore, the purpose of this study was to survey t... Read More about Ankle osteoarthritis: an online survey of current treatment practices of UK-based podiatrists and physiotherapists.

Plantar pressures in people with midfoot osteoarthritis: cross-sectional findings from the Clinical Assessment Study of the Foot (2023)
Journal Article
Lithgow, M. J., Buldt, A. K., Munteanu, S. E., Marshall, M., Thomas, M. J., Peat, G., …Menz, H. B. (2024). Plantar pressures in people with midfoot osteoarthritis: cross-sectional findings from the Clinical Assessment Study of the Foot. Gait & Posture, 108, 243-249. https://doi.org/10.1016/j.gaitpost.2023.12.008

Background
Midfoot osteoarthritis (OA) is a common condition, however its aetiology is not well understood. Understanding how plantar pressures differ between people with and without midfoot OA may provide insight... Read More about Plantar pressures in people with midfoot osteoarthritis: cross-sectional findings from the Clinical Assessment Study of the Foot.

Cohort study investigating gout flares and management in UK general practice (2023)
Journal Article
Finnikin, S., Mallen, C. D., & Roddy, E. (in press). Cohort study investigating gout flares and management in UK general practice. BMC Primary Care, 24(1), 246. https://doi.org/10.1186/s12875-023-02201-7

Background: Gout is the most common inflammatory arthritis and is almost exclusively managed in primary care, however the course and severity of the condition is variable and poorly characterised. This research aims improve understanding about the fr... Read More about Cohort study investigating gout flares and management in UK general practice.

How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey (2023)
Journal Article
Prior, J. A., Roddy, E., Solis-Trapala, I., Cornwall, N., Jinks, C., Abhishek, A., …Hider, S. (in press). How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey. Rheumatology Advances in Practice, 7(3), Article rkad102. https://doi.org/10.1093/rap/rkad102

Nonsurgical management of hallux valgus: findings of a randomised pilot and feasibility trial (2023)
Journal Article
Menz, H. B., Lim, P. Q. X., Hurn, S. E., Mickle, K. J., Buldt, A. K., Cotchett, M. P., …Munteanu, S. E. (in press). Nonsurgical management of hallux valgus: findings of a randomised pilot and feasibility trial. Journal of Foot and Ankle Research, 16(1), Article 78. https://doi.org/10.1186/s13047-023-00677-1

Background
Hallux valgus is a common and disabling condition. This randomised pilot and feasibility trial aimed to determine the feasibility of conducting a parallel group randomised trial to evaluate the effectiveness of a nonsurgical intervention... Read More about Nonsurgical management of hallux valgus: findings of a randomised pilot and feasibility trial.

Implementing treat-to-target urate-lowering therapy during hospitalizations for gout flares (2023)
Journal Article
Russell, M. D., Ameyaw-Kyeremeh, L., Dell'Accio, F., Lapham, H., Head, N., Stovin, C., …Galloway, J. B. (in press). Implementing treat-to-target urate-lowering therapy during hospitalizations for gout flares. Rheumatology, https://doi.org/10.1093/rheumatology/kead574

Objectives
To evaluate a strategy designed to optimize care and increase uptake of urate-lowering therapy (ULT) during hospitalizations for gout flares.

Methods
We conducted a prospective cohort study to evaluate a strategy that combined optimal... Read More about Implementing treat-to-target urate-lowering therapy during hospitalizations for gout flares.

A multi-professional survey of UK practice in the use of intra-articular corticosteroid injection for symptomatic first metatarsophalangeal joint osteoarthritis (2023)
Journal Article
Backhouse, M. R., Halstead, J., Roddy, E., Dhukaram, V., Chapman, A., Arnold, S., & Bruce, J. (in press). A multi-professional survey of UK practice in the use of intra-articular corticosteroid injection for symptomatic first metatarsophalangeal joint osteoarthritis. Journal of Foot and Ankle Research, 16(1), Article 71. https://doi.org/10.1186/s13047-023-00672-6

Background: The first metatarsophalangeal joint is the most common site of osteoarthritis (OA) in the foot and ankle. Intra-articular corticosteroid injections are widely used for this condition, but little is known about their use in practice. This... Read More about A multi-professional survey of UK practice in the use of intra-articular corticosteroid injection for symptomatic first metatarsophalangeal joint osteoarthritis.

Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink (2023)
Journal Article
Roddy, E., Bajpai, R., Forrester, H., James Partington, R., D Mallen, C., Clarson, L. E., …Muller, S. (2023). Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, ard-2023-224154. https://doi.org/10.1136/ard-2023-224154

Objectives:
To determine the risk of adverse events associated with colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating allopurinol for gout.

Methods:
We conducted two matched retrospective cohort studies in... Read More about Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink.

Association of Bone Shape and Alignment Analyzed Using Statistical Shape Modeling With Severity of First Metatarsophalangeal Joint Osteoarthritis (2023)
Journal Article
Buldt, A. K., Gregory, J. S., Munteanu, S. E., Allan, J. J., Tan, J. M., Auhl, M., …Menz, H. B. (2023). Association of Bone Shape and Alignment Analyzed Using Statistical Shape Modeling With Severity of First Metatarsophalangeal Joint Osteoarthritis. Arthritis Care & Research, https://doi.org/10.1002/acr.25237

Objective
We aimed to explore the relationship between bone shape and radiographic severity in individuals with first metatarsophalangeal joint osteoarthritis (first MTP joint OA).

Methods
Weightbearing lateral and dorsoplantar radiographs were... Read More about Association of Bone Shape and Alignment Analyzed Using Statistical Shape Modeling With Severity of First Metatarsophalangeal Joint Osteoarthritis.

Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study (2023)
Journal Article
Sokhal, B. S., Matetić, A., Abhishek, A., Banerjee, A., Partington, R., Roddy, E., …Mamas, M. A. (2023). Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study. American Journal of Cardiology, 206, 210-218. https://doi.org/10.1016/j.amjcard.2023.08.138

Data are limited on whether the causes of emergency department (ED) encounters for cardiovascular diseases (CVDs) and associated clinical outcomes vary by frailty status. Using the United States Nationwide ED Sample, selected CVD encounters (acute my... Read More about Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study.

Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY (2023)
Journal Article
Russell, M. D., Massey, J., Roddy, E., MacKenna, B., Bacon, S., Goldacre, B., …Galloway, J. B. (2023). Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY. The Lancet Rheumatology, 5(10), e622-e632. https://doi.org/10.1016/S2665-9913%2823%2900206-0

Background
Gout is the most prevalent inflammatory arthritis, yet one of the worst managed. Our objective was to assess how the COVID-19 pandemic impacted incidence and quality of care for people with gout in England, UK.

Methods
With the approv... Read More about Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY.