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In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum (2022)
Journal Article
Okokon, J. E., Etuk, I. C., Thomas, P. S., Drijfhout, F. P., Claridge, T. D., & Li, W. (2022). In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum. Biomedicine and Pharmacotherapy, https://doi.org/10.1016/j.biopha.2022.113153

Solanum anomalum is a plant used ethnomedically for the treatment of diabetes. The study was aimed to validate ethnomedical claims in rat model and identify the likely antidiabetic compounds. Leaf extract (70–210 mg/kg/day) and fractions (140 mg/kg/d... Read More about In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum.

Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis (2019)
Journal Article
Aldulaimi, O., Drijfhout, F., Uche, F. I., Horrocks, P., & Li, W. (2019). Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis. BMC Complementary and Alternative Medicine, 183 -?. https://doi.org/10.1186/s12906-019-2589-2

BACKGROUND Cylicodiscus gabunensis Harms (Family Leguminosae) (CG) is an African medicinal plant used as a treatment of various ailments including malaria, liver diseases, and gastrointestinal disturbances. Its extracts showed potent in vitro antiba... Read More about Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis.

Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer (2017)
Journal Article
de Wolf, E., Abdullah, M. I., Jones, S. M., Menezes, K., Moss, D. M., Drijfhout, F., …Richardson, A. (2017). Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer. Scientific reports, https://doi.org/10.1038/s41598-017-05595-4

Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol have suggested that statins may be useful to treat cancer. However, prospective clinical trials have yet to demonstrate significant efficacy. We have previo... Read More about Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer.

A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms (2017)
Journal Article
Aldulaimi, O., Uche a, F. I., Hameed, H., Mbye, H., Ullah, I., Drijfhout, F., …Li, W. (2017). A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms. Journal of Ethnopharmacology, 198, 221-225. https://doi.org/10.1016/j.jep.2017.01.014

Ethnopharmacological relevance and aim A decoction of the bark of Cylicodiscus gabunensis Harms is used as a traditional medicine in the treatment of malaria in Nigeria. This study aims to validate the antimalarial potency of this decoction in vitro... Read More about A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms.

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Uche, F. I., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. W. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Planta Medica, 82(S01), https://doi.org/10.1055/s-0036-1596584

Ovarian cancer remains one of the main causes of death in all gynecologic malignancies [1]. Natural products continue to be important sources of clinically approved anti-cancer drugs [2, 3]. Triclisia subcordata Oliv (Menispermeaceae) is a medicinal... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata (2016)
Journal Article
Uche, F., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. (2016). Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytotherapy Research, 1533-1539. https://doi.org/10.1002/ptr.5660

Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata.