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Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in (2020)
Journal Article
Gilchrist. (2020). Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in. PloS one, https://doi.org/10.1371/journal.pone.0229300

INTRODUCTION: Lung clearance index (LCI) is a sensitive measure of early lung disease, but adoption into clinical practice has been slow. Challenges include the time taken to perform each test. We recently described a closed-circuit inert gas wash-in... Read More about Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in.

Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review. (2019)
Journal Article
Gilchrist. (2019). Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review. BMJ Paediatrics Open, https://doi.org/10.1136/bmjpo-2019-000572

Background: Nusinersen has been used to treat spinal muscular atrophy type 1 (SMA1) in the UK since 2017. While initial trials showed neuromuscular benefit from treating SMA1, there is little information on the respiratory effects of nusinersen. We a... Read More about Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review..

Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres (2019)
Journal Article
Ditchfield, N., Carroll, W., & Gilchrist, F. (2019). Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.09.004

Highlights IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA. The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity. More than one third of UK CF... Read More about Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres.

An approach to the child with a wet cough. (2019)
Journal Article
Gilchrist. (2019). An approach to the child with a wet cough. Paediatric Respiratory Reviews, 75-81. https://doi.org/10.1016/j.prrv.2018.11.002

When children have a wet cough, it suggests the presence of secretions in their airways. This often has an infectious aetiology which is usually a self-limiting viral infection requiring no investigation or treatment. In those with acute wet cough it... Read More about An approach to the child with a wet cough..

Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. (2018)
Journal Article
Gilchrist. (2018). Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. BMJ Paediatrics Open, e000367 - ?. https://doi.org/10.1136/bmjpo-2018-000367

Objectives: Chest CT is increasingly used to monitor disease progression in children with cystic fibrosis (CF) but there is no national guideline regarding its use. Our objective was to assess the indications for undertaking chest CT and the protocol... Read More about Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres..

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. (2018)
Journal Article
Gilchrist. (2018). Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, CD012798 - ?. https://doi.org/10.1002/14651858.CD012798.pub2

BACKGROUND: Cystic fibrosis is the most common life-limiting autosomal recessive genetic disorder in white populations. Distal intestinal obstruction syndrome (DIOS) is an important morbidity in cystic fibrosis. It is the result of the accumulation o... Read More about Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis..

Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children (2018)
Journal Article
Gilchrist. (2018). Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children. Physiological Reports, e13752. https://doi.org/10.14814/phy2.13752

Measurement of lung function can be difficult in young children. Structured light plethysmography (SLP) is a novel, noncontact method of measuring tidal breathing that monitors displacement of the thoraco-abdominal wall. SLP was used to compare breat... Read More about Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children.

Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions (2017)
Journal Article
Gilchrist. (2017). Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions. Clinical and Experimental Allergy, 838-840. https://doi.org/10.1111/cea.12946

During childhood, exacerbation of asthma is the most common medical reason for admission to hospital in the UK. Each year 44,000 children are admitted to hospital in the UK with 40-50 children dying as a result of asthma [1]. Weather patterns and sea... Read More about Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions.

Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator (2017)
Journal Article
Gilchrist. (2017). Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator. Physiological Reports, https://doi.org/10.14814/phy2.13168

Structured light plethysmography (SLP) is a light-based, noncontact technique that measures tidal breathing by monitoring displacements of the thoracoabdominal (TA) wall. We used SLP to measure tidal breathing parameters and their within-subject vari... Read More about Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator.

Assessing chronic cough in children (2016)
Journal Article
Gilchrist. (2016). Assessing chronic cough in children. Paediatrics and Child Health, 273-275. https://doi.org/10.1016/j.paed.2016.03.002

Cough is a protective physiological reflex that aids the clearance of airway secretions and aspirated material. As such, it is normal to cough. Coughing becomes abnormal when the frequency or severity impacts on the child's ability to eat, sleep, pla... Read More about Assessing chronic cough in children.

A review of prednisolone prescribing for children with acute asthma in the UK (2016)
Journal Article
Gilchrist, F. J., Ahmad, A. N., Batchelor, H. K., Marriott, J. F., & Lenney, W. (2016). A review of prednisolone prescribing for children with acute asthma in the UK. Journal of Asthma, 53(6), 563 -566. https://doi.org/10.3109/02770903.2015.1118498

INTRODUCTION: Worldwide asthma guidelines recommend short courses of oral prednisolone in children with acute exacerbations generating high prescription numbers. There is a paucity of evidence to inform the optimal dose and course duration. This has... Read More about A review of prednisolone prescribing for children with acute asthma in the UK.

Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes (2015)
Journal Article
Gilchrist, F. (2015). Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes. Practical Diabetes, 333-335a. https://doi.org/10.1002/pdi.1984

The UK Cystic Fibrosis (CF) Trust guidelines state that the diagnosis of CF related diabetes (CFRD) should only be made after an oral glucose tolerance test in the diabetic range and hyperglycaemia on serial monitoring. We report three patients with... Read More about Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes.

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis (2015)
Journal Article
Gilchrist, F. J., Belcher, J., Jones, A. M., Smith, D., Smyth, A. R., Southern, K. W., …Lenney, W. (2015). Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis. ERJ Open Research, 1(2), https://doi.org/10.1183/23120541.00044-2015

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeru... Read More about Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis.

Research is the Future, the Future is……. (2015)
Journal Article
Gilchrist, F. J. (2015). Research is the Future, the Future is……. Paediatric Respiratory Reviews, 17, 32 - 33. https://doi.org/10.1016/j.prrv.2015.08.008

Over the past two decades, Professor Lenney has established the Paediatric Respiratory Department at the Royal Stoke University Hospital as a centre recognised for high quality research. A broad portfolio of clinical and laboratory based research is... Read More about Research is the Future, the Future is……..

The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens (2015)
Journal Article
Gilchrist. (2015). The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens. Analytical Methods, 818 -824. https://doi.org/10.1039/c4ay02981j

There is interest in the development of exhaled breath tests for the detection of lower airway infection in children with cystic fibrosis. The first stage of this process is the identification of volatile organic compounds (VOCs) released into the ga... Read More about The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens.

Bacterial distribution in the lungs of children with protracted bacterial bronchitis (2014)
Journal Article
Narang, R., Bakewell, K., Peach, J., Clayton, S., Samuels, M., Alexander, J., …Gilchrist, F. J. (2014). Bacterial distribution in the lungs of children with protracted bacterial bronchitis. PloS one, 9(9), Article e108523. https://doi.org/10.1371/journal.pone.0108523

OBJECTIVES: Flexible bronchoscopy with bronchoalveolar lavage (FB-BAL) is increasingly used for the microbiological confirmation of protracted bacterial bronchitis (PBB) in children with a chronic wet cough. At our centre, when performing FB-BAL for... Read More about Bacterial distribution in the lungs of children with protracted bacterial bronchitis.