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Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator (2017)
Journal Article
Gilchrist. (2017). Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator. Physiological Reports, https://doi.org/10.14814/phy2.13168

Structured light plethysmography (SLP) is a light-based, noncontact technique that measures tidal breathing by monitoring displacements of the thoracoabdominal (TA) wall. We used SLP to measure tidal breathing parameters and their within-subject vari... Read More about Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator.

Chronic Cough In Children (2017)
Journal Article
Hine, C., Gilchrist, F., & Carroll, W. (2017). Chronic Cough In Children. Paediatrics and Child Health, 27(3), 121 - 127. https://doi.org/10.1016/j.paed.2017.02.001

All children cough. Despite the ubiquity of this common symptom, it remains a concern for many parents and results in a significant number of health consultations. Nearly every child in the UK will present to their family doctor with cough as the pre... Read More about Chronic Cough In Children.

Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract) (2016)
Journal Article
Gilchrist, & Roffe. (2016). Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract). European Respiratory Journal, https://doi.org/10.1183/13993003.congress-2016.PA4156

Background
The extent of respiratory compromise following a stroke depends on any pre-existing respiratory illness and the aetiology, location and extent of the lesion. Acquired respiratory infection in subsequent days may alter respiratory function... Read More about Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract).

Assessing chronic cough in children (2016)
Journal Article
Gilchrist. (2016). Assessing chronic cough in children. Paediatrics and Child Health, 273-275. https://doi.org/10.1016/j.paed.2016.03.002

Cough is a protective physiological reflex that aids the clearance of airway secretions and aspirated material. As such, it is normal to cough. Coughing becomes abnormal when the frequency or severity impacts on the child's ability to eat, sleep, pla... Read More about Assessing chronic cough in children.

A review of prednisolone prescribing for children with acute asthma in the UK (2016)
Journal Article
Gilchrist, F. J., Ahmad, A. N., Batchelor, H. K., Marriott, J. F., & Lenney, W. (2016). A review of prednisolone prescribing for children with acute asthma in the UK. Journal of Asthma, 53(6), 563 -566. https://doi.org/10.3109/02770903.2015.1118498

INTRODUCTION: Worldwide asthma guidelines recommend short courses of oral prednisolone in children with acute exacerbations generating high prescription numbers. There is a paucity of evidence to inform the optimal dose and course duration. This has... Read More about A review of prednisolone prescribing for children with acute asthma in the UK.

A systematic review of early life factors which adversely affect subsequent lung function (2016)
Journal Article
Kouzouna, A., Gilchrist, F., Ball, V., Kyriacou, T., Henderson, J., Pandyan, A., & Lenney, W. (2016). A systematic review of early life factors which adversely affect subsequent lung function. Paediatric Respiratory Reviews, 20, 67-75. https://doi.org/10.1016/j.prrv.2016.03.003

It has been known for many years that multiple early life factors can adversely affect lung function and future respiratory health. This is the first systematic review to attempt to analyse all these factors simultaneously. We adhered to strict a pri... Read More about A systematic review of early life factors which adversely affect subsequent lung function.

Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes (2015)
Journal Article
Gilchrist, F. (2015). Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes. Practical Diabetes, 333-335a. https://doi.org/10.1002/pdi.1984

The UK Cystic Fibrosis (CF) Trust guidelines state that the diagnosis of CF related diabetes (CFRD) should only be made after an oral glucose tolerance test in the diabetic range and hyperglycaemia on serial monitoring. We report three patients with... Read More about Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes.

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis (2015)
Journal Article
Gilchrist, F. J., Belcher, J., Jones, A. M., Smith, D., Smyth, A. R., Southern, K. W., …Lenney, W. (2015). Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis. ERJ Open Research, 1(2), https://doi.org/10.1183/23120541.00044-2015

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeru... Read More about Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis.

Research is the Future, the Future is……. (2015)
Journal Article
Gilchrist, F. J. (2015). Research is the Future, the Future is……. Paediatric Respiratory Reviews, 17, 32 - 33. https://doi.org/10.1016/j.prrv.2015.08.008

Over the past two decades, Professor Lenney has established the Paediatric Respiratory Department at the Royal Stoke University Hospital as a centre recognised for high quality research. A broad portfolio of clinical and laboratory based research is... Read More about Research is the Future, the Future is……..

Developing a handheld record for patients with cystic fibrosis (2015)
Journal Article
Narayan, O., Davies, S., Tibbins, C., Rees, J., Lenney, W., & Gilchrist, F. (2015). Developing a handheld record for patients with cystic fibrosis. Patient Related Outcome Measures, 2015(6), 225 - 228. https://doi.org/10.2147/PROM.S86298

Patient handheld records (PHHRs) promote self-management and empower the holder to take a more active role in the management of their disease. They have been used successfully in improving preventative care for children and have contributed to improv... Read More about Developing a handheld record for patients with cystic fibrosis.

The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens (2015)
Journal Article
Gilchrist. (2015). The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens. Analytical Methods, 818 -824. https://doi.org/10.1039/c4ay02981j

There is interest in the development of exhaled breath tests for the detection of lower airway infection in children with cystic fibrosis. The first stage of this process is the identification of volatile organic compounds (VOCs) released into the ga... Read More about The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens.

The problems and limitations of cohort studies (2014)
Journal Article
Gilchrist. (2014). The problems and limitations of cohort studies. Breathe, 306-311. https://doi.org/10.1183/20734735.002313

Chronic obstructive pulmonary disease (COPD) is the third most common cause
of mortality worldwide and it is important to discover whether risk factors can be
identified from studies undertaken in childhood.
Numerous longitudinal cohort studies ha... Read More about The problems and limitations of cohort studies.

Bacterial distribution in the lungs of children with protracted bacterial bronchitis (2014)
Journal Article
Narang, R., Bakewell, K., Peach, J., Clayton, S., Samuels, M., Alexander, J., …Gilchrist, F. J. (2014). Bacterial distribution in the lungs of children with protracted bacterial bronchitis. PloS one, 9(9), Article e108523. https://doi.org/10.1371/journal.pone.0108523

OBJECTIVES: Flexible bronchoscopy with bronchoalveolar lavage (FB-BAL) is increasingly used for the microbiological confirmation of protracted bacterial bronchitis (PBB) in children with a chronic wet cough. At our centre, when performing FB-BAL for... Read More about Bacterial distribution in the lungs of children with protracted bacterial bronchitis.

The screening and diagnosis of cystic fibrosis-related diabetes in the United Kingdom (2014)
Journal Article
Wickens-Mitchell, K. L., Gilchrist, F. J., McKenna, D., Raffeeq, P., & Lenney, W. (2014). The screening and diagnosis of cystic fibrosis-related diabetes in the United Kingdom. Journal of Cystic Fibrosis, 13(5), 589-592. https://doi.org/10.1016/j.jcf.2014.01.008

Introduction
The cystic fibrosis-related diabetes (CFRD) guidelines produced by the UK CF Trust differ from those used in Europe and the US. We conducted a study to establish current practice.

Method
Paediatric and adult questionnaires were devi... Read More about The screening and diagnosis of cystic fibrosis-related diabetes in the United Kingdom.

Itraconazole and inhaled fluticasone causing hypothalamic–pituitary–adrenal axis suppression in adults with cystic fibrosis (2013)
Journal Article
Gilchrist, F. J. (2013). Itraconazole and inhaled fluticasone causing hypothalamic–pituitary–adrenal axis suppression in adults with cystic fibrosis. Journal of Cystic Fibrosis, 399-402. https://doi.org/10.1016/j.jcf.2012.10.007

Background
Although there have been case reports of hypothalamic–pituitary–adrenal (HPA) axis suppression in patients with cystic fibrosis (CF) caused by the combination of oral itraconazole and inhaled fluticasone, to date no study has assessed the... Read More about Itraconazole and inhaled fluticasone causing hypothalamic–pituitary–adrenal axis suppression in adults with cystic fibrosis.