All Outputs (19)

PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review (2024)
Journal Article
Kirkby, M., Sabri, A. H. B., Holmes, A., Moss, G. P. J., & Scurr, D. (in press). PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review. Journal of Pharmacy and Pharmacology, 76(10), 1284–1300. https://doi.org/10.1093/jpp/rgae080

Objectives
Poly(amidoamine) dendrimers have been widely investigated as potential nanomaterials that can enhance the skin permeation of topically applied drugs. This article reviews the studies that have used dendrimers as penetration enhancers and... Read More about PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review.

Microneedle-Mediated Permeation Enhancement of Chlorhexidine Digluconate: Mechanistic Insights Through Imaging Mass Spectrometry (2022)
Journal Article
Kirkby, M., Sabri, A. B., Scurr, D., & Moss, G. (2022). Microneedle-Mediated Permeation Enhancement of Chlorhexidine Digluconate: Mechanistic Insights Through Imaging Mass Spectrometry. Pharmaceutical Research, 39(8), 1945-1958. https://doi.org/10.1007/s11095-022-03309-8

Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution (2021)
Journal Article
Kirkby, M., Sabri, A. B., Scurr, D. J., & Moss, G. P. (2021). Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution. European Journal of Pharmaceutics and Biopharmaceutics, 159, 77-87. https://doi.org/10.1016/j.ejpb.2020.12.014

Chlorhexidine digluconate (CHG) is a cationic bisbiguanide used in the UK as the first-line skin antiseptic prior to surgery in the UK due to its favourable efficacy and safety profile, high affinity for skin binding and minimal reports of resistance... Read More about Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution.

Development of a Gaussian Process - feature selection model to characterise (poly)dimethylsiloxane (Silastic (R)) membrane permeation (2020)
Journal Article
Moss. (2020). Development of a Gaussian Process - feature selection model to characterise (poly)dimethylsiloxane (Silastic (R)) membrane permeation. Journal of Pharmacy and Pharmacology, https://doi.org/10.1111/jphp.13263

Objectives The current study aims to determine the effect of physicochemical descriptor selection on models of polydimethylsiloxane permeation. Methods A total of 2942 descriptors were calculated for a data set of 77 chemicals. Data were processed to... Read More about Development of a Gaussian Process - feature selection model to characterise (poly)dimethylsiloxane (Silastic (R)) membrane permeation.

The influence of diffusion cell type and experimental temperature on machine learning models of skin permeability (2019)
Journal Article
Ashrafi, P., Sun, Y., Davey, N., Wilkinson, S. C., & Moss, G. P. (2020). The influence of diffusion cell type and experimental temperature on machine learning models of skin permeability. Journal of Pharmacy and Pharmacology, 72(2), 197-208. https://doi.org/10.1111/jphp.13203

Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. (2018)
Journal Article
Holmes, A. M., Heylings, J. R., Wan, K., & Moss, G. P. (2019). Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. International Journal of Antimicrobial Agents, 53(4), 500-507. https://doi.org/10.1016/j.ijantimicag.2018.12.012

The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characteris... Read More about Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens..

Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression (2018)
Journal Article
Moss. (2018). Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression. Journal of Pharmacy and Pharmacology, 361-373. https://doi.org/10.1111/jphp.12863

Objectives
The aim of this study was to investigate how to improve predictions from Gaussian Process models by optimising the model hyperparameters.

Methods
Optimisation methods, including Grid Search, Conjugate Gradient, Random Search, Evoluti... Read More about Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression.

Pharmacy staff perspectives on the role of community pharmacy in the provision of first aid and responding to emergencies: a qualitative study. (2017)
Presentation / Conference
Liaskou, M., White, S., Moss, G., Ratcliffe, N., & Cook, J. (2017, April). Pharmacy staff perspectives on the role of community pharmacy in the provision of first aid and responding to emergencies: a qualitative study. Presented at Health Services Research and Pharmacy Practice Conference, University of Nottingham, UK

No abstract

Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: Characterisation by in vitro percutaneous absorption studies and Time-of-Flight Secondary Ion Mass Spectrometry (2017)
Journal Article
Holmes, A. M., Scurr, D. J., Heylings, J. R., Wan, K., & Moss, G. P. (2017). Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: Characterisation by in vitro percutaneous absorption studies and Time-of-Flight Secondary Ion Mass Spectrometry. European Journal of Pharmaceutical Sciences, 104, 90-101. https://doi.org/10.1016/j.ejps.2017.03.034

Abstract Skin penetration and localisation of chlorhexidine digluconate (CHG) within the skin have been investigated in order to better understand and optimise the delivery using a nano polymeric delivery system of this topically-applied antimicrobia... Read More about Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: Characterisation by in vitro percutaneous absorption studies and Time-of-Flight Secondary Ion Mass Spectrometry.

Pharmacy students’ views on community pharmacy provision of first aid and responding to medical emergencies: a scenario-based questionnaire study (2016)
Presentation / Conference
Shah, P., White, S., Moss, G., & Ratcliffe, N. (2016, September). Pharmacy students’ views on community pharmacy provision of first aid and responding to medical emergencies: a scenario-based questionnaire study. Poster presented at Royal Pharmaceutical Society (RPS), Annual Conference 2016, ICC Birmingham, UK

Support vector regression to estimate the permeability enhancement of potential transdermal enhancers (2016)
Journal Article
Moss. (2016). Support vector regression to estimate the permeability enhancement of potential transdermal enhancers. Journal of Pharmacy and Pharmacology, 170-184. https://doi.org/10.1111/jphp.12508

Objectives
Searching for chemicals that will safely enhance transdermal drug delivery is a significant challenge. This study applies support vector regression (SVR) for the first time to estimating the optimal formulation design of transdermal hydro... Read More about Support vector regression to estimate the permeability enhancement of potential transdermal enhancers.

Introduction (2015)
Book Chapter
Moss, G. P. (2015). Introduction. In Novel Delivery Systems for Transdermal and Intradermal Drug Delivery (1-40). Wiley. https://doi.org/10.1002/9781118734506.ch1

This chapter describes the physiology and structure of the skin, emphasising and focusing on the skin's main barrier to permeation – the stratum corneum – and how its structure and nature, compared to other regions and layers of the skin, results in... Read More about Introduction.

Predictive Methods in Percutaneous Absorption (2015)
Book
Moss, G. P., Gullick, D. R., & Wilkinson, S. C. (2015). Predictive Methods in Percutaneous Absorption. (1). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-47371-9

Provides a comprehensive critique of models of percutaneous absorption, their source data and both their limitations and correct use

Enriches readers’ understanding of the implications of various models

Shows how to tailor models to particular... Read More about Predictive Methods in Percutaneous Absorption.

The application of machine learning to the modelling of percutaneous absorption: An overview and guide (2015)
Journal Article
Ashrafi, P., Moss, G., Wilkinson, S., Davey, N., & Sun, Y. (2015). The application of machine learning to the modelling of percutaneous absorption: An overview and guide. SAR and QSAR in Environmental Research, 26(3), 181-204. https://doi.org/10.1080/1062936x.2015.1018941

Machine learning (ML) methods have been applied to the analysis of a range of biological systems. This paper reviews the application of these methods to the problem domain of skin permeability and addresses critically some of the key issues. Specific... Read More about The application of machine learning to the modelling of percutaneous absorption: An overview and guide.

Linear or non-linear models for percutaneous absorption? (2015)
Journal Article
Moss. (2015). Linear or non-linear models for percutaneous absorption?. International Journal of Cosmetic Science, 144 -144. https://doi.org/10.1111/ics.12196

Simulated Drug Discovery Process to Conduct a Synoptic Assessment of Pharmacy Students (2014)
Journal Article
Richardson, A., Curtis, A. D., Moss, G. P., Pearson, R. J., White, S., Rutten, F. J., …Maddock, K. (2014). Simulated Drug Discovery Process to Conduct a Synoptic Assessment of Pharmacy Students. American journal of pharmaceutical education, 78(2), 41. https://doi.org/10.5688/ajpe78241

Objective. To implement and assess a task-based learning exercise that prompts pharmacy students to integrate their understanding of different disciplines.

Design. Master of pharmacy (MPharm degree) students were provided with simulated informatio... Read More about Simulated Drug Discovery Process to Conduct a Synoptic Assessment of Pharmacy Students.

The Contributions of the Celtic Masters and Their Associates (2013)
Journal Article
Moss, G. (2013). The Contributions of the Celtic Masters and Their Associates. Skin Pharmacology and Physiology, 26(4-6), 343-355. https://doi.org/10.1159/000352012

This article summarizes the work of 4 researchers in the field of percutaneous absorption - Keith Brain, Mark Cronin, Dermot McCafferty and John Pugh. It summarizes their main achievements in this field and reviews their major contributions to the br... Read More about The Contributions of the Celtic Masters and Their Associates.

Distribution and Visualisation of Chlorhexidine Within the Skin Using ToF-SIMS: A Potential Platform for the Design of More Efficacious Skin Antiseptic Formulations (2013)
Journal Article
Judd, A. M., Scurr, D. J., Heylings, J. R., Wan, K., & Moss, G. P. (2013). Distribution and Visualisation of Chlorhexidine Within the Skin Using ToF-SIMS: A Potential Platform for the Design of More Efficacious Skin Antiseptic Formulations. Pharmaceutical Research, 30(7), 1896-1905. https://doi.org/10.1007/s11095-013-1032-5

Purpose
In order to increase the efficacy of a topically applied antimicrobial compound the permeation profile, localisation and mechanism of action within the skin must first be investigated.

Methods
Time-of-flight secondary ion mass spectromet... Read More about Distribution and Visualisation of Chlorhexidine Within the Skin Using ToF-SIMS: A Potential Platform for the Design of More Efficacious Skin Antiseptic Formulations.

Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface (2013)
Journal Article
Judd, A. M., Moss, G. P., Heylings, J., Wan, K., & Yang, Y. (2013). Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface. Proceedings of SPIE, 8580, Article ARTN 85800G. https://doi.org/10.1117/12.2004754

Polyamidoamine (PAMAM) dendrimers have been topically applied to the skin and utilised as a permeation enhancer for a range of therapeutic compounds. However, very little is known about the mechanism of enhancement. This study used optical coherence... Read More about Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface.