All Outputs (8)

Abstract A085: miR-222/221 in aggressive breast cancer (2013)
Journal Article
Di Leva, G., Piovan, C., Cheung, D., Briskin, D., Kumar, A., Nuovo, G., …Croce, C. (2013). Abstract A085: miR-222/221 in aggressive breast cancer. Molecular Cancer Research, 11(10_Supplement), A085-A085. https://doi.org/10.1158/1557-3125.advbc-a085

MicroRNAs (miRNAs) are small non coding RNAs that regulate gene expression at post-transcriptional level through translational inhibition and/or degradation of mRNA target genes. Recent evidence points to a widespread role for miRNAs in the initiatio... Read More about Abstract A085: miR-222/221 in aggressive breast cancer.

MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. (2013)
Journal Article
Di Leva, G., Garofalo, M., Jeon, Y., Nuovo, G. J., Middleton, J., Secchiero, P., …Croce, C. M. (2013). MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PloS one, 8(6), e67581 - ?. https://doi.org/10.1371/journal.pone.0067581

Lung cancer is the leading cause of cancer mortality in the world today. Although some advances in lung cancer therapy have been made, patient survival is still poor. MicroRNAs (miRNAs) can act as oncogenes or tumor-suppressor genes in human malignan... Read More about MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer..

The Role of microRNAs in the Tumorigenesis of Ovarian Cancer. (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). The Role of microRNAs in the Tumorigenesis of Ovarian Cancer. Frontiers in oncology, 3, 153 - ?. https://doi.org/10.3389/fonc.2013.00153

Epithelial ovarian cancer (EOC) is a complex disease, with multiple histological subtypes recognized. There have been major advances in the understanding of the cellular and molecular biology of this human malignancy, however the survival rate of wom... Read More about The Role of microRNAs in the Tumorigenesis of Ovarian Cancer..

Editorial (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). Editorial. Clinical Biochemistry, 46(10-11), 840-841. https://doi.org/10.1016/j.clinbiochem.2013.05.060

After their discovery in mammalians, more than 20,000 publications about microRNAs have been recorded in Pubmed over the last 11 years. Although some aspects of their biology are still unknown and need some clarifications, it is now clear that microR... Read More about Editorial.

Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer. (2013)
Journal Article
Jeon, Y., Nuovo, G. J., Midddleton, J., Joshi, P., Nazaryan, N., Di Leva, G., …Croce, C. M. (2013). Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer. Cancer Research, 73(8_Supplement), LB-244-LB-244. https://doi.org/10.1158/1538-7445.am2013-lb-244

Lung cancer is the most common cause of cancer death worldwide. Despite years of research, the prognosis for patients with lung cancer remains dismal. The most frequent type, non-small cell lung cancer (NSCLC) (85%), shows an overall five year surviv... Read More about Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer..

Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. (2013)
Journal Article
Taccioli, C., Chen, H., Garofalo, M., Jiang, Y., Di Leva, G., Alder, H., …Fong, L. Y. Y. (2013). Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. Cancer Research, 73(8_Supplement), LB-241-LB-241. https://doi.org/10.1158/1538-7445.am2013-lb-241

Dietary zinc deficiency (ZD) is implicated in the pathogenesis of human esophageal squamous cell carcinoma (ESCC). microRNA-31 (miR-31) is overexpressed in human ESCC. In the rat a ZD diet promotes esophageal carcinogenesis by inducing cellular proli... Read More about Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats..

Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. (2013)
Journal Article
Di Leva, G., Piovan, C., Gasparini, P., Ngankeu, A., Taccioli, C., Briskin, D., …Croce, C. M. (2013). Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLOS genetics, 9(3), Article ARTN e1003311. https://doi.org/10.1371/journal.pgen.1003311

MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological processes that can contribute to cancer. Although tumor-suppressive and oncogenic functions have been characterized for some miRNAs, the majority of microRNAs have not b... Read More about Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status..

miRNA profiling of cancer (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). miRNA profiling of cancer. Current Opinion in Genetics and Development, 23(1), 3-11. https://doi.org/10.1016/j.gde.2013.01.004

A steadily growing number of studies have shown that microRNAs have key roles in the regulation of cellular processes and that their dysregulation is essential to keep the malignant phenotype of cancer cells. The distorted and unique expression profi... Read More about miRNA profiling of cancer.