All Outputs (3)

Abstract A085: miR-222/221 in aggressive breast cancer (2013)
Presentation / Conference Contribution
Di Leva, G., Piovan, C., Cheung, D., Briskin, D., Kumar, A., Nuovo, G., Fassan, M., Coppola, V., Garofalo, M., & Croce, C. Abstract A085: miR-222/221 in aggressive breast cancer. Presented at AACR Special Conference on Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications, San Diego, CA, USA; October 3-6, 2013

MicroRNAs (miRNAs) are small non coding RNAs that regulate gene expression at post-transcriptional level through translational inhibition and/or degradation of mRNA target genes. Recent evidence points to a widespread role for miRNAs in the initiatio... Read More about Abstract A085: miR-222/221 in aggressive breast cancer.

Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer. (2013)
Presentation / Conference Contribution
Jeon, Y.-J., Nuovo, G. J., Midddleton, J., Joshi, P., Nazaryan, N., Di Leva, G., Romano, G., Crawford, M., Nana-Sinkam, P., Garofalo, M., & Croce, C. M. Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer. Presented at AACR 104th Annual Meeting 2013; Apr 6-10, 2013, Washington, DC, USA

Lung cancer is the most common cause of cancer death worldwide. Despite years of research, the prognosis for patients with lung cancer remains dismal. The most frequent type, non-small cell lung cancer (NSCLC) (85%), shows an overall five year surviv... Read More about Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer..

Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. (2013)
Presentation / Conference Contribution
Taccioli, C., Chen, H., Garofalo, M., Jiang, Y., Di Leva, G., Alder, H., Middleton, J., Smalley, K. J., Bottoni, A., Costinean, S., Farber, J. L., Croce, C. M., & Fong, L. Y. Y. Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. Presented at AACR 104th Annual Meeting 2013; Apr 6-10, 2013, Washington, DC, USA

Dietary zinc deficiency (ZD) is implicated in the pathogenesis of human esophageal squamous cell carcinoma (ESCC). microRNA-31 (miR-31) is overexpressed in human ESCC. In the rat a ZD diet promotes esophageal carcinogenesis by inducing cellular proli... Read More about Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats..