Dysregulation of ubiquitin homeostasis and ß-catenin signaling promote spinal muscular atrophy

Wishart, TM; Becker, CG; Wirth, B; Gillingwater, TH; Parson, SH; Skehel, PA; Becker, T; Robinson, IM; Mutsaers, CA; Riessland, M; Reimer, MM; Hunter, G; Hannam, ML; Eaton, SL; Fuller, HR; Roche, SL; Somers, E; Morse, R; Young, PJ; Lamont, DJ; Hammerschmidt, M; Joshi, A; Hohenstein, P; Morris, GE

doi:10.1172/JCI71318

All Outputs (3)

The influence of storage parameters on measurement of survival motor neuron (SMN) protein levels: Implications for pre-clinical studies and clinical trials for spinal muscular atrophy (2014)
Journal Article
Hunter, G., Roche, S. L., Somers, E., Fuller, H. R., & Gillingwater, T. H. (2014). The influence of storage parameters on measurement of survival motor neuron (SMN) protein levels: Implications for pre-clinical studies and clinical trials for spinal muscular atrophy. Neuromuscular Disorders, 24(11), 973-977. https://doi.org/10.1016/j.nmd.2014.05.013

The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry (2014)
Journal Article
Fuller, H. R., Hurtado, M. L., Wishart, T. M., & Gates, M. A. (2014). The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry. Proteome Science, 1-20. https://doi.org/10.1186/1477-5956-12-20

BACKGROUND: Idiopathic Parkinson's disease is marked by degeneration of dopamine neurons projecting from the substantia nigra to the striatum. Although proteins expressed by the target striatum can positively affect the viability and growth of dopami... Read More about The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry.

Dysregulation of ubiquitin homeostasis and ß-catenin signaling promote spinal muscular atrophy (2014)
Journal Article
Wishart, T., Becker, C., Wirth, B., Gillingwater, T., Parson, S., Skehel, P., …Morris, G. (2014). Dysregulation of ubiquitin homeostasis and ß-catenin signaling promote spinal muscular atrophy. Journal of Clinical Investigation, 1821 -1834. https://doi.org/10.1172/JCI71318

The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results from low levels of survival motor neuron (SMN) protein; however, it is unclear how reduced SMN promotes SMA development. Here, we determined that ubiquitin-depend... Read More about Dysregulation of ubiquitin homeostasis and ß-catenin signaling promote spinal muscular atrophy.