All Outputs (3)

Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy (2019)
Journal Article
Šoltić, D., Shorrock, H. K., Allardyce, H., Wilson, E. L., Holt, I., Synowsky, S. A., …Fuller, H. (2019). Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy. Human Molecular Genetics, 3515-3527. https://doi.org/10.1093/hmg/ddz195

Cardiac pathology is emerging as a prominent systemic feature of spinal muscular atrophy (SMA), but little is known about the underlying molecular pathways. Using quantitative proteomics analysis, we demonstrate widespread molecular defects in heart... Read More about Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy.

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle (2019)
Journal Article
Holt, I., Fuller, H., Lam, L., Sewry, C., Shirran, S., Zhang, Q., …Morris, G. (2019). Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle. Scientific reports, https://doi.org/10.1038/s41598-019-50728-6

Nesprins, nuclear envelope spectrin-repeat proteins encoded by the SYNE1 and SYNE2 genes, are involved in localization of nuclei. The short isoform, nesprin-1-alpha2, is required for relocation of the microtubule organizer function from centromeres t... Read More about Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

Breast reconstruction affects coping mechanisms in breast cancer survivors. (2019)
Journal Article
Lake, B., Fuller, H., Rastall, S., & Usman, T. (2019). Breast reconstruction affects coping mechanisms in breast cancer survivors. Indian Journal of Surgery, 43-50. https://doi.org/10.1007/s12262-017-1712-1

Coping strategies used by women with breast cancer are vital for adjustment to their disease. Whilst it is clear that factors such as age at diagnosis, social support and ethnicity can influence coping mechanisms, there is currently no information ab... Read More about Breast reconstruction affects coping mechanisms in breast cancer survivors..