All Outputs (2)

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model (2020)
Journal Article
Paape, D., Prendergast, C., Price, H., Doehl, J., & Smith, D. (2020). Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model. Parasites and Vectors, 13, Article 132. https://doi.org/10.1186/s13071-020-3999-1

Background: Proving that specifc genes are essential for the intracellular viability of Leishmania parasites within macrophages remains a challenge for the identifcation of suitable targets for drug development. This is especially evident in the ab... Read More about Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model.

Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model (2020)
Journal Article
Agostino, V., Trinconi, C., Galuppo, M., Price, H., & Uliana, S. (2020). Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model. Acta tropica, 206, Article 105444. https://doi.org/10.1016/j.actatropica.2020.105444

New drugs for the treatment of human leishmaniasis are urgently needed, considering the limitations of current available options. However, pre-clinical evaluation of drug candidates for leishmaniasis is challenging. The use of luciferase-expressing p... Read More about Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model.