Global profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite Trypanosoma brucei

Tate, EW; Wright, MH; Paape, D; Price, H; Smith, DF

doi:10.1021/acsinfecdis.6b00034

All Outputs (2)

First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa) (2016)
Journal Article
Sangaré, I., Dabiré, R., Guiguemdé, R., Fournet, F., Price, H., Djibougou, A., …Banuls, A. (2016). First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa). Research Journal of Parasitology, 12(1), 27-32. https://doi.org/10.3923/jp.2017.27.32

Background and Objective: Human Visceral Leishmaniasis (HVL) is a systemic neglected tropical diseases and potentially lethal disease caused by infection with protozoan parasites of the Leishmania genus. In the causal, agent of HVL is L. infantum and... Read More about First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa).

Global profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite Trypanosoma brucei (2016)
Journal Article
Tate, E., Wright, M., Paape, D., Price, H., & Smith, D. (2016). Global profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite Trypanosoma brucei. ACS Infectious Diseases, 2(6), 427-441. https://doi.org/10.1021/acsinfecdis.6b00034

The enzyme N-myristoyltransferase (NMT) catalyzes the essential fatty acylation of substrate proteins with myristic acid in eukaryotes and is a validated drug target in the parasite Trypanosoma brucei, the causative agent of African trypanosomiasis (... Read More about Global profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite Trypanosoma brucei.