Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria
(2023)
Journal Article
Nguyen, S. T., Du, D., Wychrij, D., Cain, M. D., Wu, Q., Klein, R. S., …Goldberg, D. E. (2023). Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America, 120(26), Article e2306318120. https://doi.org/10.1073/pnas.2306318120
Histidine-rich protein II (HRPII) is secreted by Plasmodium falciparum during the blood stage of malaria infection. High plasma levels of HRPII are associated with cerebral malaria, a severe and highly fatal complication of malaria. HRPII has been sh... Read More about Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria.