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Distal Versus Conventional Radial Access for Coronary Angiography and Intervention: The DISCO RADIAL Trial. (2022)
Journal Article
Nolan. (2022). Distal Versus Conventional Radial Access for Coronary Angiography and Intervention: The DISCO RADIAL Trial. JACC: Cardiovascular Interventions, 15(12), 1191 - 1201. https://doi.org/10.1016/j.jcin.2022.04.032

BACKGROUND: Currently, transradial access (TRA) is the recommended access for coronary procedures because of increased safety, with radial artery occlusion (RAO) being its most frequent complication, which will increasingly affect patients undergoing... Read More about Distal Versus Conventional Radial Access for Coronary Angiography and Intervention: The DISCO RADIAL Trial..

Mode of presentation and mortality amongst patients hospitalized with heart failure?: a report from The First Euro Heart Failure Survey (2019)
Journal Article
Shoaib, A., Farag, M., Nolan, J., Rigby, A., Patwala, A., Rashid, M., Kwok, C., Perveen, R., Clark, A., Komajda, M., & Cleland, J. (2019). Mode of presentation and mortality amongst patients hospitalized with heart failure?: a report from The First Euro Heart Failure Survey. Zeitschrift für Kardiologie, 108, 510-519. https://doi.org/10.1007/s00392-018-1380-6

Background:
Heart failure is heterogeneous in aetiology, pathophysiology and presentation. Despite this diversity, clinical trials of patients hospitalized for HF deal with this problem as a single entity, which may be one reason for repeated failur... Read More about Mode of presentation and mortality amongst patients hospitalized with heart failure?: a report from The First Euro Heart Failure Survey.

Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts (2018)
Journal Article
Shoaib, A., Kinnaird, T., Curzen, N., Kontopantelis, E., Ludman, P., de Belder, M., Rashid, M., Shing Kwok, C., Nolan, J., Zaman, A., & Mamas, M. (2018). Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts. Circulation: Cardiovascular Interventions, 11(11), https://doi.org/10.1161/circinterventions.118.006824

Background: There are limited data on outcomes of patients with previous CABG presenting with NSTEMI undergoing PCI. We compare clinical characteristics and outcomes in NSTEMI patients undergoing PCI with or without prior CABG surgery in a national c... Read More about Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts.

Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review (2018)
Journal Article
Ayyaz Ul Haq, M., Rashid, M., Gilchrist, I. C., Bertrand, O., Shing Kwok, C., Wai Wong, C., Mansour, H. M., Baghdaddy, Y., Nolan, J., van Leeuwen, M. A., & Mamas, M. A. (2018). Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review. Circulation Journal, 82(11), 2736. https://doi.org/10.1253/circj.CJ-18-0389

Background

We sought to systematically review the available literature on limb dysfunction after transradial or transfemoral cardiac catheterization.

Methods & Results
MEDLINE and EMBASE were searched for studies evaluating any transradial or... Read More about Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review.

Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society (2018)
Journal Article
Mamas, M., Tosh, J., Hulme, W., Hoskins, N., Bungey, G., Ludman, P., de Belder, M., Shing Kwok, C., Verin, N., Kinnaird, T., Bennett, E., Curzen, N., Nolan, J., & Kontopantelis, E. (2018). Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society. Circulation: Cardiovascular Quality and Outcomes, 11(5), https://doi.org/10.1161/circoutcomes.117.004482

Background: Transradial access (TRA) for percutaneous coronary intervention (PCI) is associated with a reduced risk of mortality compared with transfemoral access, access site–related bleeding complications, and shorter length of stay. The budget imp... Read More about Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society.

Accelerated patent haemostasis using a procoagulant disk: a protocol designed to minimise the risk of radial artery occlusion following cardiac catheterisation (2018)
Journal Article
Ayyaz Ul Haq, M., Nazir, S. A., Rashid, M., Shing Kwok, C., Mubashiruddin, S., Alisiddiq, Z., Shoaib b, A., Ratib, K., Mamas, M. A., & Nolan, J. (2019). Accelerated patent haemostasis using a procoagulant disk: a protocol designed to minimise the risk of radial artery occlusion following cardiac catheterisation. Cardiovascular Revascularization Medicine, 20(2), 137-142. https://doi.org/10.1016/j.carrev.2018.03.026

Purpose
Radial artery occlusion flowing cardiac catheterisation has been linked to flow reduction and prolonged compression. We investigate whether these factors can be optimised following transradial cardiac catheterisation by using an accelerated... Read More about Accelerated patent haemostasis using a procoagulant disk: a protocol designed to minimise the risk of radial artery occlusion following cardiac catheterisation.

Burden of 30-day readmissions after PCI in 824,747 patients in the USA: predictors, causes and cost. Insights from the Nationwide Readmission Database (2018)
Journal Article
Rashid, M., Curzen, N., Nolan, J., Bagur, R., Mamas, M., Potts, J., Kontopantelis, E., Kinnaird, T., Rao, S., & Kwok, C. (2018). Burden of 30-day readmissions after PCI in 824,747 patients in the USA: predictors, causes and cost. Insights from the Nationwide Readmission Database. JACC. Cardiovascular interventions, 655-674. https://doi.org/10.1016/j.jcin.2018.01.248

Objectives
This study aimed to examine the 30-day unplanned readmissions rate, predictors of readmission, causes of readmissions, and clinical impact of readmissions after percutaneous coronary intervention (PCI).

Background
Unplanned rehospital... Read More about Burden of 30-day readmissions after PCI in 824,747 patients in the USA: predictors, causes and cost. Insights from the Nationwide Readmission Database.

Vascular access site and outcomes in 58,870 patients undergoing PCI with a previous history of coronary bypass surgery: results from the British Cardiovascular Interventions Society National database (2018)
Journal Article
Mamas, M., & Nolan, J. (2018). Vascular access site and outcomes in 58,870 patients undergoing PCI with a previous history of coronary bypass surgery: results from the British Cardiovascular Interventions Society National database. JACC. Cardiovascular interventions, 482-492. https://doi.org/10.1016/j.jcin.2017.12.020

Objectives
Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, access site choice and outcomes of patients undergoing PCI with previous coronary artery bypass grafting (CABG) were studied.

Back... Read More about Vascular access site and outcomes in 58,870 patients undergoing PCI with a previous history of coronary bypass surgery: results from the British Cardiovascular Interventions Society National database.

The effect of pre-procedure sublingual nitroglycerin on radial artery diameter and Allen’s test outcome - relevance to transradial catheterization (2018)
Journal Article
Chong, A., Lo, T., George, S., Ratib, K., Mamas, M., & Nolan, J. (2018). The effect of pre-procedure sublingual nitroglycerin on radial artery diameter and Allen’s test outcome - relevance to transradial catheterization. Cardiovascular Revascularization Medicine, 19(2), 163-167. https://doi.org/10.1016/j.carrev.2017.07.016

Background
The radial artery is increasingly used for cardiac procedures, but is a relatively small vessel that is prone to spasm when instrumented. Intra-arterial nitroglycerine has been shown to reduce radial spasm but first requires arterial acce... Read More about The effect of pre-procedure sublingual nitroglycerin on radial artery diameter and Allen’s test outcome - relevance to transradial catheterization.

Vascular access site and outcomes among 26,807 chronic total coronary occlusion angioplasty cases from the British Cardiovascular Interventions Society National database (2017)
Journal Article
Mamas, M., & Nolan, J. (2017). Vascular access site and outcomes among 26,807 chronic total coronary occlusion angioplasty cases from the British Cardiovascular Interventions Society National database. JACC: Cardiovascular Interventions, 635-644. https://doi.org/10.1016/j.jcin.2016.11.055

Objectives
The aim of this study was to assess, using a national percutaneous coronary intervention (PCI) database, access-site choice and outcomes after chronic total occlusion (CTO) PCI.

Background
Given the influence of access site on outcome... Read More about Vascular access site and outcomes among 26,807 chronic total coronary occlusion angioplasty cases from the British Cardiovascular Interventions Society National database.

Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom (2017)
Journal Article
Hulme, W., Sperrin, M., Kontopantelis, E., Ratib, K., Ludman, P., Sirker, A., Kinnaird, T., Curzen, N., Shing Kwok, C., De Belder, M., Nolan, J., & Mamas, M. (2017). Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom. Circulation: Cardiovascular Interventions, 10(2), 4279. https://doi.org/10.1161/CIRCINTERVENTIONS.116.004279

Background—
The radial artery is increasingly adopted as the primary access site for cardiac catheterization because of patient preference, lower bleeding rates, cost effectiveness, and reduced risk of mortality in high-risk patient groups. Concerns... Read More about Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom.

Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis (2016)
Journal Article
Nagaraja, V., Ooi, S., Nolan, J., Large, A., De Belder, M., Ludman, P., Bagur, R., Curzen, N., Matsukage, T., Yoshimachi, F., Shing Kwok, C., Berry, C., & Mamas, M. A. (2016). Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 5(12), https://doi.org/10.1161/JAHA.116.004598

Background
Up to half of patients undergoing percutaneous coronary intervention have multivessel coronary artery disease (MVD) with conflicting data regarding optimal revascularization strategy in such patients. This paper assesses the evidence for... Read More about Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis.

Influence of access site choice for cardiac catheterization on risk of adverse neurological events: a systematic review and meta-analysis (2016)
Journal Article
Mamas, & Nolan. (2016). Influence of access site choice for cardiac catheterization on risk of adverse neurological events: a systematic review and meta-analysis. American Heart Journal, 107-119. https://doi.org/10.1016/j.ahj.2016.06.027

Background: Stroke is a rare but potentially catastrophic complication of cardiac catheterization. While some procedural aspects are known to influence stroke risk, the impact of radial versus femoral access site use is unclear. Early observational s... Read More about Influence of access site choice for cardiac catheterization on risk of adverse neurological events: a systematic review and meta-analysis.

Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention (2016)
Journal Article
Mamas, & Nolan. (2016). Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention. American Journal of Cardiology, 610-620. https://doi.org/10.1016/j.amjcard.2016.05.059

Anemia is common in patients undergoing percutaneous coronary intervention (PCI), and current guidelines fail to offer recommendations for its management. This review aims to examine the relation between baseline anemia and mortality, major adverse c... Read More about Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention.

Is there a relationship of operator and center volume with access site related outcomes?: an analysis from the British Cardiovascular Intervention Society (2016)
Journal Article
Nolan, & Mamas. (2016). Is there a relationship of operator and center volume with access site related outcomes?: an analysis from the British Cardiovascular Intervention Society. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/circinterventions.115.003333

Background: Transradial access (TRA) is associated with reduced access site related bleeding complications and mortality post percutaneous coronary intervention (PCI). The objective of this study is to examine the relationship between access site pra... Read More about Is there a relationship of operator and center volume with access site related outcomes?: an analysis from the British Cardiovascular Intervention Society.

Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis (2016)
Journal Article
Mamas, Rashid, M., & Nolan, J. (2016). Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis. Heart, https://doi.org/10.1136/heartjnl-2015-308956

Abstract Objective: First-degree atrioventricular block is frequently encountered in clinical practice and is generally considered a benign process. However, there is emerging evidence that prolonged PR interval may be associated with adverse outcome... Read More about Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis.

Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure (2015)
Journal Article
Nolan. (2015). Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Heart, 223 - 229. https://doi.org/10.1136/heartjnl-2015-308428

Objective We aimed to define the prognostic value of the heart rate range during a 24 h period in patients with chronic heart failure (CHF).

Methods Prospective observational cohort study of 791 patients with CHF associated with left ventricular s... Read More about Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure.

Letter to the Editor Regarding “Efficacy of Radial Versus Femoral Access in the Acute Coronary Syndrome: Is it the operator or the operation that matters?” by Michel LeMay MD and colleagues (2015)
Journal Article
Mamas, M., & Nolan, J. (2015). Letter to the Editor Regarding “Efficacy of Radial Versus Femoral Access in the Acute Coronary Syndrome: Is it the operator or the operation that matters?” by Michel LeMay MD and colleagues. JACC: Cardiovascular Interventions, 1405-1409. https://doi.org/10.1016/j.jcin.2015.06.016

In the recently published MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX) trial, the use of transradial access (TRA) compared to transfemoral access (TFA) during percutaneous coronary i... Read More about Letter to the Editor Regarding “Efficacy of Radial Versus Femoral Access in the Acute Coronary Syndrome: Is it the operator or the operation that matters?” by Michel LeMay MD and colleagues.

Intra-arterial vasodilators to prevent radial artery spasm: a systematic review and pooled analysis of clinical studies (2015)
Journal Article
Nolan, Rashid, & Mamas. (2015). Intra-arterial vasodilators to prevent radial artery spasm: a systematic review and pooled analysis of clinical studies. Cardiovascular Revascularization Medicine, 484-490. https://doi.org/10.1016/j.carrev.2015.08.008

Objectives
The aim of this study is to review the available literature on the efficacy and safety of agents used for prevention of RAS.

Background
Different vasodilator agents have been used to prevent radial artery spasm (RAS) in patients under... Read More about Intra-arterial vasodilators to prevent radial artery spasm: a systematic review and pooled analysis of clinical studies.

Effect of access site, gender, and indication on clinical outcomes after percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society (BCIS) (2015)
Journal Article
Mamas, & Nolan. (2015). Effect of access site, gender, and indication on clinical outcomes after percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society (BCIS). American Heart Journal, 164-172. https://doi.org/10.1016/j.ahj.2015.04.018

Background
Gender is a strong predictor of periprocedural major bleeding complications after percutaneous coronary intervention (PCI). The access site represents an important site of such bleeding complications, which has driven adoption of the tran... Read More about Effect of access site, gender, and indication on clinical outcomes after percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society (BCIS).