All Outputs (4)

Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1 (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1. Journal of Theoretical Biology, 592,

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1.

A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation. Journal of Theoretical Biology, Article 111874. https://doi.org/10.1016/j.jtbi.2024.111874

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation.

A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: The effects of co-implantation (2019)
Journal Article
Naire, & Kuiper. (2019). A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: The effects of co-implantation. Journal of Tissue Engineering, 1-14. https://doi.org/10.1177/2041731419827792

We present a mathematical model of cartilage regeneration after cell therapy, to show how co-implantation of stem cells (mesenchymal stem cells) and chondrocytes into a cartilage defect can impact chondral healing. The key mechanisms involved in the... Read More about A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: The effects of co-implantation.

A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - I: The effects of growth factors (2019)
Journal Article
Campbell, K., Kuiper, J., & Naire, S. (2019). A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - I: The effects of growth factors. Journal of Tissue Engineering, 1-16. https://doi.org/10.1177/2041731419827791

Autologous Chondrocyte Implantation is a cell-based therapy for treating chondral defects. The procedure begins by inserting chondrocytes into the defect region. The chondrocytes initiate healing by proliferating and depositing extracellular matrix,... Read More about A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - I: The effects of growth factors.