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All Outputs (74)

Characteristics of patients with giant cell arteritis who experience visual symptoms (2019)
Journal Article
Shen Chean, C., Prior, J., Helliwell, T., Belcher, J., Mackie, S. L., Hider, S., …Mallen, C. (2019). Characteristics of patients with giant cell arteritis who experience visual symptoms. Rheumatology International, 39, 1789-1796. https://doi.org/10.1007/s00296-019-04422-5

Permanent vision loss is one of the most serious complications of giant cell arteritis (GCA) and therefore prompt diagnosis is paramount. However, diagnosis of GCA remains challenging due to its frequently non-specific presentation. Our aim was to id... Read More about Characteristics of patients with giant cell arteritis who experience visual symptoms.

Gender-specific risk factors for gout: a systematic review of cohort studies (2019)
Journal Article
Evans, P. L., Prior, J. A., Belcher, J., Hay, C. A., Mallen, C. D., & Roddy, E. (2019). Gender-specific risk factors for gout: a systematic review of cohort studies. Advances in Rheumatology, 59, Article 24. https://doi.org/10.1186/s42358-019-0067-7

BACKGROUND: Though gout is more prevalent in men than women, it remains unclear whether gender influences risk factors for incident gout. We aimed to systematically review all cohort studies examining risk factors for the development of gout by gend... Read More about Gender-specific risk factors for gout: a systematic review of cohort studies.

202 Gout attack trajectories in a 3-year cohort study in primary care (2019)
Journal Article
Watson, L., Belcher, J., Mallen, C. D., & Roddy, E. (2019). 202 Gout attack trajectories in a 3-year cohort study in primary care. Rheumatology, 58(Supplement_3), https://doi.org/10.1093/rheumatology/kez107.018

Background: Gout affects 2.5% of adults in the UK but is often poorly managed. Whilst the hallmark of gout is recurrent sudden-onset attacks of acute joint pain and swelling, little is known about the pattern (trajectory) of attacks over time. We aim... Read More about 202 Gout attack trajectories in a 3-year cohort study in primary care.

216 Characteristics of patients with prevalent giant cell arteritis in UK primary care (2019)
Journal Article
Twomlow, E. L., Prior, J. A., Mackie, S. L., Helliwell, T., Hider, S. L., Belcher, J., …Mallen, C. D. (2019). 216 Characteristics of patients with prevalent giant cell arteritis in UK primary care. Rheumatology, 58(Supplement_3), https://doi.org/10.1093/rheumatology/kez107.032

Background: Giant cell arteritis (GCA) is a rare, but serious condition affecting older people. Prompt diagnosis remains challenging due to non-specific presentations. Furthermore, there are marked variations in GP referral and management approaches.... Read More about 216 Characteristics of patients with prevalent giant cell arteritis in UK primary care.

E042 Predicting duration of glucocorticoid therapy in an inception cohort of patients with polymyalgia rheumatica (2019)
Journal Article
Morton, C., Muller, S., Hider, S., Belcher, J., Mallen, C. D., & Helliwell, T. (2019). E042 Predicting duration of glucocorticoid therapy in an inception cohort of patients with polymyalgia rheumatica. Rheumatology, 58(Supplement_3), https://doi.org/10.1093/rheumatology/kez110.041

Background: Extended duration of glucocorticoid (GC) therapy can be considered a poor outcome in people with polymyalgia rheumatica (PMR). Being able to predict the likelihood of extended GC therapy at diagnosis would enable earlier specialist referr... Read More about E042 Predicting duration of glucocorticoid therapy in an inception cohort of patients with polymyalgia rheumatica.

Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death (2019)
Journal Article
Lambie, M., Teece, L., Johnson, D. W., Petrie, M., Mactier, R., Solis-Trapala, I., …Davies, S. J. (2019). Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death. Nephrology Dialysis Transplantation, 1585-1591. https://doi.org/10.1093/ndt/gfz034

Background Risk of Encapsulating Peritoneal Sclerosis (EPS) is strongly associated with the duration of peritoneal dialysis (PD), such that patients who have been on PD for some time may consider elective transfer to haemodialysis to mitigate risk o... Read More about Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death.

Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study (2018)
Journal Article
Mallen, Roddy, Belcher, Clarson, & Muller. (2018). Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study. Arthritis Research and Therapy, 20, Article 243. https://doi.org/10.1186/s13075-018-1746-1

BACKGROUND: An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lowering therapy (ULT) on developm... Read More about Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study.

Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies (2018)
Journal Article
Evans, P. L., Prior, J. A., Belcher, J., Mallen, C., Hay, C. A., & Roddy, E. (2018). Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies. Arthritis Research and Therapy, 20, Article 136. https://doi.org/10.1186/s13075-018-1612-1

BACKGROUND: Gout treatment remains suboptimal. Identifying populations at risk of developing gout may provide opportunities for prevention. Our aim was to assess the risk of incident gout associated with obesity, hypertension and diuretic use. METHOD... Read More about Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies.

Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported (2018)
Journal Article
Whittle, R., Peat, G., Belcher, J., Collins, G. S., & Riley, R. D. (2018). Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported. Journal of Clinical Epidemiology, 102, 38-49. https://doi.org/10.1016/j.jclinepi.2018.05.008

Objective Measurement error in predictor variables may threaten the validity of clinical prediction models. We sought to evaluate the possible extent of the problem. A secondary objective was to examine whether predictors are measured at the intende... Read More about Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported.

How common is depression in patients with polymyalgia rheumatica? (2018)
Journal Article
Mallen, Bucknall, Belcher, & Hider. (2018). How common is depression in patients with polymyalgia rheumatica?. Clinical Rheumatology, 1633 - 1638. https://doi.org/10.1007/s10067-017-3691-9

Depression is common in inflammatory disorders such as rheumatoid arthritis and systemic lupus erythematosus and negatively impacts on outcomes. Given the long-term nature of polymyalgia rheumatica (PMR) and its glucocorticoid treatment, these patien... Read More about How common is depression in patients with polymyalgia rheumatica?.

Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial (2018)
Journal Article
Kigozi, J., Jowett, S., Nicholl, B. I., Lewis, M., Bartlam, B., Green, D., …Mallen, C. D. (2018). Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial. Arthritis Care and Research, 70(12), 1787-1794. https://doi.org/10.1002/acr.23568

OBJECTIVE: To investigate the cost-effectiveness (cost-utility) of introducing general practitioner screening for anxiety and depression in patients consulting with osteoarthritis (OA). METHODS: A cluster-randomised trial-based economic evaluation to... Read More about Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial.

Factors Influencing Allopurinol Initiation in Primary Care. (2017)
Journal Article
Roddy, Mallen, Clarson, Belcher, & Hider. (2017). Factors Influencing Allopurinol Initiation in Primary Care. Annals of Family Medicine, 15(6), 557 - 560. https://doi.org/10.1370/afm.213

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number... Read More about Factors Influencing Allopurinol Initiation in Primary Care..

Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis (2017)
Journal Article
Prior, J. A., Ranjbar, H., Belcher, J., Mackie, S. L., Helliwell, T., Liddle, J., & Mallen, C. D. (2017). Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis. BMC Medicine, 15, Article 120. https://doi.org/10.1186/s12916-017-0871-z

BACKGROUND: Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study's objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific cha... Read More about Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis.

Public priorities for osteoporosis and fracture research: results from a general population survey (2017)
Journal Article
Paskins, Z., Jinks, C., Mahmood, W., Jayakumar, P., Sangan, C. B., Belcher, J., & Gwilym, S. (2017). Public priorities for osteoporosis and fracture research: results from a general population survey. Archives of Osteoporosis, 12(45), https://doi.org/10.1007/s11657-017-0340-5

This is the first national study of public and patient research priorities in osteoporosis and fracture. We have identified new research areas of importance to members of the public, particularly ‘access to information from health professionals’. The... Read More about Public priorities for osteoporosis and fracture research: results from a general population survey.

The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care (2017)
Journal Article
Mallen, C. D., Nicholl, B. I., Lewis, M., Bartlam, B., Green, D., Jowett, S., …Peat, G. (2017). The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care. PLoS Medicine, e1002273 -?. https://doi.org/10.1371/journal.pmed.1002273

BACKGROUND: This study aimed to evaluate whether prompting general practitioners (GPs) to routinely assess and manage anxiety and depression in patients consulting with osteoarthritis (OA) improves pain outcomes. METHODS AND FINDINGS: We conducted a... Read More about The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care.

LEVELS OF SALIVARY C-REACTIVE PROTEIN, PROCALCITONIN AND NEUTROPHIL ELASTASE CAN PREDICT EXACERBATIONS IN COPD AND DETERMINE THOSE PATIENTS AT HIGH RISK OF RE-EXACERBATION (2016)
Journal Article
Patel, N., Thorpe, G., Jones, P., Adamson, V., Belcher, J., & Spiteri, M. A. (2016). LEVELS OF SALIVARY C-REACTIVE PROTEIN, PROCALCITONIN AND NEUTROPHIL ELASTASE CAN PREDICT EXACERBATIONS IN COPD AND DETERMINE THOSE PATIENTS AT HIGH RISK OF RE-EXACERBATION. Thorax, 71(S3), A39-A40. https://doi.org/10.1136/thoraxjnl-2016-209333.72

Saliva has numerous practical advantages as a diagnostic bio-sample for management of long term conditions. We have previously demonstrated that C-reactive protein (CRP), procalcitonin (PCT) and neutrophil elastase (NE) can be reliably and reproducib... Read More about LEVELS OF SALIVARY C-REACTIVE PROTEIN, PROCALCITONIN AND NEUTROPHIL ELASTASE CAN PREDICT EXACERBATIONS IN COPD AND DETERMINE THOSE PATIENTS AT HIGH RISK OF RE-EXACERBATION.

Clinical Significance of Medial Versus Lateral Compartment Patellofemoral Osteoarthritis: Cross-Sectional Analyses in an Adult Population With Knee Pain (2016)
Journal Article
Ukachukwu, V., Duncan, R., Belcher, J., Marshall, M., Stefanik, J., Crossley, K., …Peat, G. (2017). Clinical Significance of Medial Versus Lateral Compartment Patellofemoral Osteoarthritis: Cross-Sectional Analyses in an Adult Population With Knee Pain. Arthritis Care and Research, 69(7), 943-951. https://doi.org/10.1002/acr.23110

Objective To determine the comparative prevalence, associations with selected patient characteristics, and clinical outcomes of medial and lateral compartment patellofemoral (PF) joint osteoarthritis (OA). Methods Information was collected by qu... Read More about Clinical Significance of Medial Versus Lateral Compartment Patellofemoral Osteoarthritis: Cross-Sectional Analyses in an Adult Population With Knee Pain.

Illness perceptions of gout patients and the use of allopurinol in primary care: baseline findings from a prospective cohort study (2016)
Journal Article
Walsh, C. P., Prior, J., Chandratre, P., Belcher, J., Mallen, C., & Roddy, E. (2016). Illness perceptions of gout patients and the use of allopurinol in primary care: baseline findings from a prospective cohort study. BMC Musculoskeletal Disorders, 17, Article 394. https://doi.org/10.1186/s12891-016-1252-z

Background Patients’ perceptions of their illness are dynamic and can directly influence aspects of management. Our aim was to examine the illness perceptions of gout patients in UK primary care and associations with allopurinol use. Methods A h... Read More about Illness perceptions of gout patients and the use of allopurinol in primary care: baseline findings from a prospective cohort study.

Widespread pain and depression are key modifiable risk factors associated with reduced social participation in older adults: A prospective cohort study in primary care. (2016)
Journal Article
Wilkie, R., Blagojevic-Bucknall, M., Belcher, J., Chew-Graham, C., Lacey, R. J., & McBeth, J. (2016). Widespread pain and depression are key modifiable risk factors associated with reduced social participation in older adults: A prospective cohort study in primary care. Medicine, 95(31), Article e4111. https://doi.org/10.1097/MD.0000000000004111

In older adults, reduced social participation increases the risk of poor health-related quality of life, increased levels of inflammatory markers and cardiovascular disease, and increased mortality. Older adults frequently present to primary care, wh... Read More about Widespread pain and depression are key modifiable risk factors associated with reduced social participation in older adults: A prospective cohort study in primary care..