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Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy (2023)
Journal Article
Dowling, L. M., Roach, P., Magnussen, E. A., Kohler, A., Pillai, S., van Pittius, D. G., …Sulé-Suso, J. (in press). Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy. PLoS ONE, 18(8), Article e0289824. https://doi.org/10.1371/journal.pone.0289824

The management of cancer patients has markedly improved with the advent of personalised medicine where treatments are given based on tumour antigen expression amongst other. Within this remit, liquid biopsies will no doubt improve this personalised c... Read More about Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy.

Fourier transform infrared spectroscopy as a non-destructive method for analysing herbarium specimens. (2023)
Journal Article
Barnes, M., Sule-Suso, J., Millett, J., & Roach, P. (2023). Fourier transform infrared spectroscopy as a non-destructive method for analysing herbarium specimens. Biology Letters, 19(3), Article 20220546. https://doi.org/10.1098/rsbl.2022.0546

Dried plant specimens stored in herbaria are an untapped treasure chest of information on environmental conditions, plant evolution and change over many hundreds of years. Owing to their delicate nature and irreplaceability, there is limited access f... Read More about Fourier transform infrared spectroscopy as a non-destructive method for analysing herbarium specimens..

Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells. (2023)
Journal Article
Solheim, J., Brandsrud, M., Kong, B., Banyasz, A., Borondics, F., Micouin, G., …Kohler, A. (2023). Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells. Scientific reports, 13(1), Article 3165. https://doi.org/10.1038/s41598-023-30130-z

It is well known that infrared microscopy of micrometer sized samples suffers from strong scattering distortions, attributed to Mie scattering. The state-of-the-art preprocessing technique for modelling and removing Mie scattering features from infra... Read More about Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells..

Detection of lipid efflux from foam cell models using a label-free infrared method (2022)
Journal Article
Xie, B., Njoroge, W., Dowling, L. M., Sulé-Suso, J., Cinque, G., & Yang, Y. (2022). Detection of lipid efflux from foam cell models using a label-free infrared method. Analyst, 147(23), 5372-5385. https://doi.org/10.1039/D2AN01041K

Cardiovascular diseases are still among the leading causes of mortality and morbidity worldwide. The build-up of fatty plaques in the arteries, leading to atherosclerosis, is the most common cause of cardiovascular diseases. The central player in ath... Read More about Detection of lipid efflux from foam cell models using a label-free infrared method.

Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency (2022)
Journal Article
Barreto, S., Al-Zubaidi, M., Dale, T., Worrall, A., Kapacee, Z., Kimber, S., …Rutter, A. (2022). Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency. Preprints, https://doi.org/10.20944/preprints202203.0143.v1

<jats:p>Human pluripotent stem cells (hPSCs) have widespread potential biomedical applications. There is a need for large-scale in vitro production of hPSCs, and optimal culture methods are vital in achieving this. Physiological oxygen (2% O2) improv... Read More about Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency.

Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases (2021)
Journal Article
Paraskevaidi, M., Baker, M., Butler, H., Byrne, H., Chakkumpulakkal, T., Loren, C., …Wood, B. (2021). Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases. Applied Spectroscopy Reviews, https://doi.org/10.1080/05704928.2021.1946076

Analytical technologies that can improve disease diagnosis are highly sought after. Current screening/diagnostic tests for several diseases are limited by their moderate diagnostic performance, invasiveness, costly and laborious methodologies or the... Read More about Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases.

Optical Photothermal Infrared Microspectroscopy Discriminates for the First Time Different Types of Lung Cells on Histopathology Glass Slides. (2021)
Journal Article
Kansiz, M., Dowling, L., Yousef, I., Guaitella, O., Borondics, F., & Sule-Suso, J. (2021). Optical Photothermal Infrared Microspectroscopy Discriminates for the First Time Different Types of Lung Cells on Histopathology Glass Slides. Analytical Chemistry, 11081 - 11088. https://doi.org/10.1021/acs.analchem.1c00309

The debate of whether a glass substrate can be used in Fourier transform infrared spectroscopy is strongly linked to its potential clinical application. Histopathology glass slides of 1 mm thickness absorb the mid-IR spectrum in the rich fingerprint... Read More about Optical Photothermal Infrared Microspectroscopy Discriminates for the First Time Different Types of Lung Cells on Histopathology Glass Slides..

Virtual Imaging for Patient Information on Radiotherapy Planning and Delivery for Prostate Cancer (2021)
Book Chapter
Martínez-Albaladejo, M., Sulé-Suso, J., Lines, D., Bisson, J., Jassal, S., & Edwards, C. (2021). Virtual Imaging for Patient Information on Radiotherapy Planning and Delivery for Prostate Cancer. In Lecture Notes in Computer Science (125-139). Springer International Publishing. https://doi.org/10.1007/978-3-030-80432-9_10

The provision of information on radiotherapy (RT) planning and delivery for patient with cancer is a vital issue in improving not only patients’ satisfaction but also patients’ compliance to treatment. In the present study, patients with prostate can... Read More about Virtual Imaging for Patient Information on Radiotherapy Planning and Delivery for Prostate Cancer.

Optimisation of sample preparation using glass slides for spectral pathology (2020)
Journal Article
Dowling, L., Roach, P., Rutter, A., Yousef, I., Pillai, S., Latham, D., …Sule-Suso, J. (2020). Optimisation of sample preparation using glass slides for spectral pathology. Applied Spectroscopy, 75(3), 343-350. https://doi.org/10.1177/0003702820945748

The clinical translation of Fourier Transform Infrared (FTIR) microspectroscopy in pathology will require bringing this technique as close as possible to standard practice in pathology departments. An important step is sample preparation for both FTI... Read More about Optimisation of sample preparation using glass slides for spectral pathology.

Identification of a Glass Substrate to Study Cells Using Fourier Transform Infrared Spectroscopy: Are We Closer to Spectral Pathology? (2019)
Journal Article
Rutter, A., Crees, J., Wright, H., Raseta, M., van Pittius, D., Roach, P., & Sulé-Suso, J. (2019). Identification of a Glass Substrate to Study Cells Using Fourier Transform Infrared Spectroscopy: Are We Closer to Spectral Pathology?. Applied Spectroscopy, 74(2), 178-186. https://doi.org/10.1177/0003702819875828

The rising incidence of cancer worldwide is causing an increase in the workload in pathology departments. This, coupled with advanced analysis methodologies, supports a developing need for techniques that could identify the presence of cancer cells i... Read More about Identification of a Glass Substrate to Study Cells Using Fourier Transform Infrared Spectroscopy: Are We Closer to Spectral Pathology?.

Striking lung cancer response to self-administration of cannabidiol: a case report and literature review (2019)
Journal Article
Sule-Suso, J., Watson, N., van Pittius, D., & Jegannathen, A. (2019). Striking lung cancer response to self-administration of cannabidiol: a case report and literature review. SAGE Open Medical Case Reports, https://doi.org/10.1177/2050313X19832160

In spite of new drugs, lung cancer is associated with a very poor prognosis. Whilst targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during follow up. Thus, new drugs or re-e... Read More about Striking lung cancer response to self-administration of cannabidiol: a case report and literature review.

Fourier transform infrared spectra of cells on glass coverslips: a further step in spectral pathology (2018)
Journal Article
Rutter, A., Crees, J., Wright, H., van Pittius, D., Yousef, I., & Sule-Suso, J. (2018). Fourier transform infrared spectra of cells on glass coverslips: a further step in spectral pathology. Analyst, 5711 - 5717. https://doi.org/10.1039/C8AN01634H

Over the last few years, great effort has been placed on developing Fourier Transform Infrared (FTIR) microspectroscopy as a tool to help in the histopathological diagnosis of cancer. The ever increasing workload in pathology departments is calling f... Read More about Fourier transform infrared spectra of cells on glass coverslips: a further step in spectral pathology.

Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. (2018)
Journal Article
Owida, H., Rutter, A., Cinque, G., Kuiper, N., Sule-Suso, J., & Yang, Y. (2018). Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. Analyst, 5979-5986. https://doi.org/10.1039/c8an01272e

Isolated and monolayer expanded chondrocytes are not the ideal cell form to produce a cartilage matrix. In articular cartilage, each chondrocyte is surrounded by a 2-4 µm thick collagen VI-rich pericellular matrix (PCM) forming a chondron. Freshly ex... Read More about Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model..

Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. (2018)
Journal Article
Baker, M., Byrne, H., Chalmers, J., Gardner, P., Goodacre, R., Henderson, A., …Sule-Suso, J. (2018). Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. Analyst, 1735 - 1757. https://doi.org/10.1039/C7AN01871A

Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have the potential to revolution... Read More about Clinical applications of infrared and Raman spectroscopy: state of play and future challenges..

Correction: Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. (2018)
Journal Article
Baker, M., Byrne, H., Chalmers, J., Gardner, P., Goodacre, R., Henderson, A., …Sule-Suso, J. (2018). Correction: Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. Analyst, 1934 - ?. https://doi.org/10.1039/C8AN90029A

Correction for 'Clinical applications of infrared and Raman spectroscopy: state of play and future challenges' by Matthew J. Baker, et al., Analyst, 2018, DOI: 10.1039/c7an01871a.

Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer (2017)
Conference Proceeding
Butcher, J. B., Rutter, A. V., Wootton, A. J., Day, C. R., & Sulé-Suso, J. (2017). Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer. In Advances in Computational Intelligence Systems (183-190). https://doi.org/10.1007/978-3-319-66939-7_15

Lung cancer is a widespread disease and it is well understood that systematic, non-invasive and early detection of this progressive and life-threatening disorder is of vital importance for patient outcomes. In this work we present a convergence of fa... Read More about Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer.

Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace (2017)
Journal Article
Shestivska, V., Rutter, A. V., Sule-Suso, J., Smith, D., & Spanel, P. (2017). Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace. Rapid Communications in Mass Spectrometry, 31(16), 1344-1352. https://doi.org/10.1002/rcm.7911

Rationale
Peroxidation of lipids in cellular membranes results in the release of volatile organic compounds (VOCs), including saturated aldehydes. The real-time quantification of trace VOCs produced by cancer cells during peroxidative stress present... Read More about Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace.

Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning (2016)
Journal Article
Siddique, M., Rutter, A., Wehbe, K., Cinque, G., Bellisola, G., & Sule-Suso, J. (2016). Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning. Analyst, 8(142), 1299-1307. https://doi.org/10.1039/c6an01914e

Over the last few years, both synchrotron-based FTIR (S-FTIR) and Raman microspectroscopies have helped to better understand the effects of drugs on cancer cells. However, cancer is a mixture of cells with different sensitivity/resistance to drugs. F... Read More about Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning.