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All Outputs (93)

Outcome-adaptive randomization in clinical trials: issues of participant welfare and autonomy (2019)
Journal Article
Sim. (2019). Outcome-adaptive randomization in clinical trials: issues of participant welfare and autonomy. Theoretical Medicine and Bioethics, 83-101. https://doi.org/10.1007/s11017-019-09481-0

Outcome-adaptive randomization (OAR) has been proposed as a corrective to certain ethical difficulties inherent in the traditional randomized clinical trial (RCT) using fixed-ratio randomization. In particular, it has been suggested that OAR redresse... Read More about Outcome-adaptive randomization in clinical trials: issues of participant welfare and autonomy.

Effect on hospital length of stay of tourniquet use during internal fixation of ankle fracture: randomized controlled trial (2018)
Journal Article
Sim, J., Grocott, N., Majeed, H., & McClelland, D. (2019). Effect on hospital length of stay of tourniquet use during internal fixation of ankle fracture: randomized controlled trial. Journal of Foot and Ankle Surgery, 58(1), 114-118. https://doi.org/10.1053/j.jfas.2018.08.023

Approximately 50% of ankle fractures require internal fixation. A tourniquet is often employed to create a bloodless operative field, but its effect on hospital length of stay (LOS) is unclear. This paper reports a parallel-group observer-blinded ran... Read More about Effect on hospital length of stay of tourniquet use during internal fixation of ankle fracture: randomized controlled trial.

Diagnostic experience of patients with fibromyalgia - A meta-ethnography (2018)
Journal Article
Sim, J., Mengshoel, A. M., Ahlsen, B., & Madden, S. (2018). Diagnostic experience of patients with fibromyalgia - A meta-ethnography. Chronic Illness, 14(3), 194-211. https://doi.org/10.1177/1742395317718035

Objective To examine how individuals experience the process and consequences of receiving a diagnosis of fibromyalgia syndrome. Methods A systematic literature search of qualitative studies up to May 2016 was performed. Twenty-eight reports including... Read More about Diagnostic experience of patients with fibromyalgia - A meta-ethnography.

The sample size debate: response to Norman Blaikie (2018)
Journal Article
Sim, J., Saunders, B., Waterfield, J., & Kingstone, T. (2018). The sample size debate: response to Norman Blaikie. International Journal of Social Research Methodology, 21(5), https://doi.org/10.1080/13645579.2018.1454642

In his detailed response to our paper on sample size in qualitative research, Norman Blaikie raises important issues concerning conceptual definitions and taxonomy. In particular, he points out the problems associated with a loose, generic applicatio... Read More about The sample size debate: response to Norman Blaikie.

Can sample size in qualitative research be determined a priori? (2018)
Journal Article
Sim, J., Saunders, B., Waterfield, J., & Kingstone, T. (2018). Can sample size in qualitative research be determined a priori?. International Journal of Social Research Methodology, 5, https://doi.org/10.1080/13645579.2018.1454643

There has been considerable recent interest in methods of determining sample size for qualitative research a priori, rather than through an adaptive approach such as saturation. Extending previous literature in this area, we identify four distinct ap... Read More about Can sample size in qualitative research be determined a priori?.

Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT. (2018)
Journal Article
Bishop, J., Sim, J., Penaloza, C., Jowett, S., Gray, R., Ferdinand, P., …Roffe, C. (2018). Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT. Health Technology Assessment, 22(14), 1 - 88. https://doi.org/10.3310/hta22140

BACKGROUND: Stroke is a major cause of death and disability worldwide. Hypoxia is common after stroke and is associated with worse outcomes. Oxygen supplementation could prevent hypoxia and secondary brain damage. OBJECTIVES: (1) To assess whether or... Read More about Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT..

Interpreting intracorporeal landscapes: how patients visualize pathophysiology and utilize medical images in their understanding of chronic musculoskeletal illness (2018)
Journal Article
Moore, A. J., Richardson, J. C., Bernard, M., & Sim, J. (2019). Interpreting intracorporeal landscapes: how patients visualize pathophysiology and utilize medical images in their understanding of chronic musculoskeletal illness. Disability and Rehabilitation, 41(14), 1647 - 1654. https://doi.org/10.1080/09638288.2018.1443162

Medical science and other sources, such as the media, increasingly inform the general public's understanding of disease. There is often discordance between this understanding and the diagnostic interpretations of health care practitioners (HCPs). In... Read More about Interpreting intracorporeal landscapes: how patients visualize pathophysiology and utilize medical images in their understanding of chronic musculoskeletal illness.

Management of incidental adrenal tumours. (2018)
Journal Article
Hanna, F., Issa, B., Sim, J., Keevil, B., & Fryer, A. (2018). Management of incidental adrenal tumours. BMJ, j5674 - ?. https://doi.org/10.1136/bmj.j5674

An incidental adrenal tumour, described in this article as an “adrenal incidentaloma,” is an adrenal mass discovered during imaging that was not performed for suspected adrenal disease. These are being detected more frequently in an ageing population... Read More about Management of incidental adrenal tumours..

Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. (2017)
Journal Article
Sim, J., Bishop, J., Gray, R., and the Stroke Oxygen Study Collaborative Group, S. O. S. I., Roffe, C., Nevatte, T., …Ferdinand, P. (2017). Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. Journal of the American Medical Association, 318(12), 1125 - 1135. https://doi.org/10.1001/jama.2017.11463

Importance: Hypoxia is common in the first few days after acute stroke, is frequently intermittent, and is often undetected. Oxygen supplementation could prevent hypoxia and secondary neurological deterioration and thus has the potential to improve r... Read More about Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial..

Saturation in qualitative research: exploring its conceptualization and operationalization (2017)
Journal Article
Saunders, B., Sim, J., Kingstone, T., Baker, S., Waterfield, J., Bartlam, B., …Jinks, C. (2018). Saturation in qualitative research: exploring its conceptualization and operationalization. Quality and Quantity, 52, 1-15. https://doi.org/10.1007/s11135-017-0574-8

Saturation has attained widespread acceptance as a methodological principle in qualitative research. It is commonly taken to indicate that, on the basis of the data that have been collected or analysed hitherto, further data collection and/or analysi... Read More about Saturation in qualitative research: exploring its conceptualization and operationalization.

Feasibility of a randomized single-blind crossover trial to assess the effects of the second-generation slow-release dopamine agonists pramipexole and ropinirole on cued recall memory in idiopathic mild or moderate Parkinson’s disease without cognitive impairment (2017)
Journal Article
Shepherd, T. A., Edelstyn, N. M., Longshaw, L., Sim, J., Watts, K., Mayes, A. R., …Ellis, S. J. (2017). Feasibility of a randomized single-blind crossover trial to assess the effects of the second-generation slow-release dopamine agonists pramipexole and ropinirole on cued recall memory in idiopathic mild or moderate Parkinson’s disease without cognitive impairment. Pilot and Feasibility Studies, https://doi.org/10.1186/s40814-017-0154-7

BACKGROUND: The aim was to assess the feasibility of a single-centre, single-blind, randomized, crossover design to explore the effects of two slow-release dopamine agonists, ropinirole and pramipexole, on cued recall in Parkinson's disease. As the d... Read More about Feasibility of a randomized single-blind crossover trial to assess the effects of the second-generation slow-release dopamine agonists pramipexole and ropinirole on cued recall memory in idiopathic mild or moderate Parkinson’s disease without cognitive impairment.

Symptom experience in non‐dialysis‐dependent chronic kidney disease: A qualitative descriptive study (2017)
Journal Article
Pugh‐Clarke, K., Cheryl Read, S., & Sim, J. (2017). Symptom experience in non‐dialysis‐dependent chronic kidney disease: A qualitative descriptive study. Journal of Renal Care, 43(4), 197-208. https://doi.org/10.1111/jorc.12208

Background
Studies indicate that symptoms attributable to impaired kidney function are important determinants of quality of life and functional status in patients with chronic kidney disease (CKD). Accordingly, symptom assessment and subsequent cont... Read More about Symptom experience in non‐dialysis‐dependent chronic kidney disease: A qualitative descriptive study.

Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients (2017)
Journal Article
Davie, S., Coyle, D., Dasgupta, I., Andronis, L., Farrington, K., Wilkie, M., …Caskey, F. (2017). Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients. BMC Nephrology, 18, Article 138. https://doi.org/10.1186/s12882-017-0554-1

BACKGROUND: Preserved residual kidney function (RKF) and normal fluid status are associated with better patient outcomes in incident haemodialysis patients. The objective of this trial is to determine whether using bioimpedance technology in prescrib... Read More about Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients.

Generating Individual Patient Preferences for the Treatment of Osteoarthritis Using Adaptive Choice-Based Conjoint (ACBC) Analysis. (2017)
Journal Article
Al-Omari, B., Sim, J., Croft, P., & Frisher, M. (2017). Generating Individual Patient Preferences for the Treatment of Osteoarthritis Using Adaptive Choice-Based Conjoint (ACBC) Analysis. Rheumatology and Therapy, 4, 167-182. https://doi.org/10.1007/s40744-017-0056-4

INTRODUCTION: To explore how adaptive choice-based conjoint (ACBC) analysis could contribute to shared decision-making in the treatment of individual patients with osteoarthritis (OA). METHODS: In-depth case study of three individuals randomly select... Read More about Generating Individual Patient Preferences for the Treatment of Osteoarthritis Using Adaptive Choice-Based Conjoint (ACBC) Analysis..

Acupuncture and electro-acupuncture for people diagnosed with subacromial pain syndrome: A multicentre randomized trial (2017)
Journal Article
Barlas, P., Lewis, J., & Sim, J. (2017). Acupuncture and electro-acupuncture for people diagnosed with subacromial pain syndrome: A multicentre randomized trial. European Journal of Pain, 1007-1019. https://doi.org/10.1002/ejp.1001

BACKGROUND: Musculoskeletal disorders have been identified globally as the second most common healthcare problem for 'years lived with disability', and of these shoulder conditions are amongst the most common, frequently associated with substantial p... Read More about Acupuncture and electro-acupuncture for people diagnosed with subacromial pain syndrome: A multicentre randomized trial.

Identifying patients with chronic widespread pain in primary care. (2017)
Journal Article
Mansfield, K., Sim, J., Croft, P., & Jordan, K. (2017). Identifying patients with chronic widespread pain in primary care. PAIN, 158, 110-119. https://doi.org/10.1097/j.pain.0000000000000733

Chronic widespread pain (CWP) is common in the general population. It is unclear how people reporting this problem present in primary care; they may regularly consult for regional pains without being recognized as having a generalized condition. Our... Read More about Identifying patients with chronic widespread pain in primary care..