All Outputs (3)

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. (2023)
Journal Article
Thompson, C. L., Hopkins, T., Bevan, C., Screen, H. R., Wright, K. T., & Knight, M. M. (in press). Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. Biomedical Materials, 18(6), https://doi.org/10.1088/1748-605X/acf976

Healthy synovium is critical for joint homeostasis. Synovial inflammation (synovitis) is implicated in the onset, progression and symptomatic presentation of arthritic joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Thus, th... Read More about Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment..

Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release (2023)
Journal Article
Davies, R., Allen, S., Mennan, C., Platt, M., Wright, K., & Kehoe, O. (2023). Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release. International Journal of Molecular Sciences, 24(11), 9242. https://doi.org/10.3390/ijms24119242

The immunomodulatory properties of MSCs can be recreated using their extracellular vesicles (EVs). Yet, the true capabilities of the MSC EVs cannot be distinguished from contaminating bovine EVs and protein derived from supplemental foetal bovine ser... Read More about Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release.

Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report (2023)
Journal Article
Wilkinson, H., McCarthy, H. S., Perry, J., Smith, T., Wright, K., & Cool, P. (2023). Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report. Cureus, 15(5), https://doi.org/10.7759/cureus.38788

There is currently no "gold-standard" method to diagnose prosthetic joint infections (PJI), and the current practice of using microbiological cultures has many limitations. The identification of the bacterial species causing the infection is crucial... Read More about Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report.