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All Outputs (85)

681 USING NANOPORE SEQUENCING TO DIAGNOSE PROSTHETIC JOINT INFECTIONS (2024)
Presentation / Conference
Wilkinson, H., Cool, P., Perry, J., Wright, K. T., McCarthy, H. S., & Hulme, C. H. (2024, April). 681 USING NANOPORE SEQUENCING TO DIAGNOSE PROSTHETIC JOINT INFECTIONS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

444 Differential Transcriptome Signatures of Success are Identified within Different Cell Populations used for Treating Cartilage Defects in the Knee (2024)
Presentation / Conference
Tierney, L., Jones, A., McCarthy, H. S., Roberts, S., Tonge, D., & Wright, K. T. (2024, April). 444 Differential Transcriptome Signatures of Success are Identified within Different Cell Populations used for Treating Cartilage Defects in the Knee. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

361 ADDITION OF THROMBIN TO BONE MARROW CONCENTRATE DURING THE TREATMENT OF ANKLE CARTILAGE DEFECTS SIGNIFICANTLY INCREASES THE CONCENTRATION OF INTERLEUKIN-1 RECEPTOR ALPHA AND PLATELET-DERIVED GROWTH FACTOR BB (2024)
Presentation / Conference
Lan, T., Wright, K. T., Makwana, N., Bing, A., McCarthy, H. S., & Hulme, C. H. (2024, April). 361 ADDITION OF THROMBIN TO BONE MARROW CONCENTRATE DURING THE TREATMENT OF ANKLE CARTILAGE DEFECTS SIGNIFICANTLY INCREASES THE CONCENTRATION OF INTERLEUKIN-1 RECEPTOR ALPHA AND PLATELET-DERIVED GROWTH FACTOR BB. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

344 CO-DESIGNING ACCEPTABLE, FEASIBLE TRIALS TO TEST DRUGS TARGETING PREVENTION OF POST-TRAUMATIC OSTEOARTHRITIS AFTER KNEE INJURY: PIPEDREAM OR REALITY? (2024)
Presentation / Conference
Kalsoum, R., Brewer, G., Lowe, C. M., Papadaki, A., Nigrelli, L., Gilbert, S., …Watt, F. E. (2024, April). 344 CO-DESIGNING ACCEPTABLE, FEASIBLE TRIALS TO TEST DRUGS TARGETING PREVENTION OF POST-TRAUMATIC OSTEOARTHRITIS AFTER KNEE INJURY: PIPEDREAM OR REALITY?. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

284 Lower Cell Number Implanted is Consistently Associated with Improved Functional Outcome Post-Autologous Chondrocyte Implantation in Longitudinal Multilevel Modelling Analyses. (2024)
Presentation / Conference
Kuiper, J. H., Dewan, V., Tierney, L., Roberts, S., Harrison, P., Gallacher, P., …Wright, K. T. (2024, April). 284 Lower Cell Number Implanted is Consistently Associated with Improved Functional Outcome Post-Autologous Chondrocyte Implantation in Longitudinal Multilevel Modelling Analyses. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

275 PATIENTS LIVING IN AREAS OF HIGHER SOCIOECONOMIC AREA DEPRIVATION HAVE SIGNIFICANTLY POORER PATIENT-REPORTED OUTCOMES FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION IN THE UNITED KINGDOM (2024)
Presentation / Conference
Ismael, S., McCarthy, H. S., Williams, M., Barnett, A., Gallacher, P., Jermin, P., …Kuiper, J. H. (2024, April). 275 PATIENTS LIVING IN AREAS OF HIGHER SOCIOECONOMIC AREA DEPRIVATION HAVE SIGNIFICANTLY POORER PATIENT-REPORTED OUTCOMES FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION IN THE UNITED KINGDOM. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study (2024)
Journal Article
Wilkinson, H., McDonald, J., McCarthy, H., Perry, J., Wright, K., Hulme, C., & Cool, P. (in press). Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study. Briefings in Functional Genomics, Article elae008. https://doi.org/10.1093/bfgp/elae008

This project investigates if third-generation genomic sequencing can be used to identify the species of bacteria causing prosthetic joint infections (PJIs) at the time of revision surgery. Samples of prosthetic fluid were taken during revision surger... Read More about Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study.

The clinical potential of meniscal progenitor cells (2024)
Journal Article
Yan, W., Wang, J., Fan, P., Roberts, S., Wright, K., & Zhang, Z. (2024). The clinical potential of meniscal progenitor cells. Journal of Cartilage & Joint Preservation (JCJP), 100166. https://doi.org/10.1016/j.jcjp.2024.100166

Introduction The meniscus is an important cushioning structure of the knee joint, the maintenance of its normal structure and function plays a crucial role in protecting the joint from early degeneration. Stem/pro... Read More about The clinical potential of meniscal progenitor cells.

SYNOVIAL FLUID PROTEOMICS AND BIOINFORMATICS HIGHLIGHTS POTENTIAL MECHANISMS OF UMBILICAL CORD-MSC INDUCED RADIOLOGICAL IMPROVEMENT IN AN OVINE MODEL OF OSTEOARTHRITIS (2023)
Journal Article
Wright, K., McDonald, J., Mennan, C., Perry, J., Peffers, M., & Hulme, C. (2023). SYNOVIAL FLUID PROTEOMICS AND BIOINFORMATICS HIGHLIGHTS POTENTIAL MECHANISMS OF UMBILICAL CORD-MSC INDUCED RADIOLOGICAL IMPROVEMENT IN AN OVINE MODEL OF OSTEOARTHRITIS. Orthopaedic Proceedings, 105-B(SUPP_16), 53-53. https://doi.org/10.1302/1358-992x.2023.16.053

AbstractObjectivesA promising therapy for early osteoarthritis (OA) is the transplantation of human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs). The synovial fluid (SF) from a pre-clinical ovine model treated with hUC-MSCs has been pr... Read More about SYNOVIAL FLUID PROTEOMICS AND BIOINFORMATICS HIGHLIGHTS POTENTIAL MECHANISMS OF UMBILICAL CORD-MSC INDUCED RADIOLOGICAL IMPROVEMENT IN AN OVINE MODEL OF OSTEOARTHRITIS.

EVALUATING THE UTILITY OF SPECT/CT FOR THE IDENTIFICATION OF CARTILAGE LESIONS: A SYSTEMATIC REVIEW (2023)
Journal Article
Rix, L., Tushingham, S., Wright, K., & Snow, M. (2023). EVALUATING THE UTILITY OF SPECT/CT FOR THE IDENTIFICATION OF CARTILAGE LESIONS: A SYSTEMATIC REVIEW. Orthopaedic Proceedings, 105-B(SUPP_16), 45-45. https://doi.org/10.1302/1358-992x.2023.16.045

AbstractObjectiveA common orthopaedic pain found in a wide spectrum of individuals, from young and active to the elderly is anterior knee pain (AKP). It is a multifactorial disorder which is thought to occur through muscular imbalance, overuse, traum... Read More about EVALUATING THE UTILITY OF SPECT/CT FOR THE IDENTIFICATION OF CARTILAGE LESIONS: A SYSTEMATIC REVIEW.

CHARACTERIZING CELLULAR COMPONENTS OF BONE MARROW ASPIRATE CONCENTRATE: A ONE-STEP CELL THERAPY FOR ANKLE CARTILAGE DEFECTS (2023)
Journal Article
Lan, T., Wright, K., Makwana, N., Bing, A., McCarthy, H., & Hulme, C. (2023). CHARACTERIZING CELLULAR COMPONENTS OF BONE MARROW ASPIRATE CONCENTRATE: A ONE-STEP CELL THERAPY FOR ANKLE CARTILAGE DEFECTS. Orthopaedic Proceedings, 105-B(SUPP_16), 62-62. https://doi.org/10.1302/1358-992x.2023.16.062

AbstractObjectivesBone marrow aspirate concentrate (BMAC), together with fibrin glue (Tisseel, Baxter, UK) and Hyaluronic acid (HA) were used as a one-step cell therapy treating patients with ankle cartilage defects in our hospital. This therapy was... Read More about CHARACTERIZING CELLULAR COMPONENTS OF BONE MARROW ASPIRATE CONCENTRATE: A ONE-STEP CELL THERAPY FOR ANKLE CARTILAGE DEFECTS.

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. (2023)
Journal Article
Thompson, C. L., Hopkins, T., Bevan, C., Screen, H. R., Wright, K. T., & Knight, M. M. (in press). Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. Biomedical Materials, 18(6), https://doi.org/10.1088/1748-605X/acf976

Healthy synovium is critical for joint homeostasis. Synovial inflammation (synovitis) is implicated in the onset, progression and symptomatic presentation of arthritic joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Thus, th... Read More about Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment..

Analysis of Synovial Fluid Proteomes After Treating an Ovine Osteoarthritic Model with Human Umbilical Cord Mesenchymal Stem Cells (2023)
Presentation / Conference
McDonald, J., Wright, K., Mennan, C., Peffers, M., Perry, J., Roberts, S., …Hulme, C. (2023, September). Analysis of Synovial Fluid Proteomes After Treating an Ovine Osteoarthritic Model with Human Umbilical Cord Mesenchymal Stem Cells. Presented at International Cartilage and Joint Preservation Society World Congress 2023, Melia Hotel Sitges, Sitges/ Barcelona

The Up-Scale Manufacture of Chondrocytes for Allogeneic Cartilage Therapies (2023)
Journal Article
Hulme, C. H., Garcia, J., Mennan, C., Perry, J., Roberts, S., Norris, K., …Wright, K. T. (2023). The Up-Scale Manufacture of Chondrocytes for Allogeneic Cartilage Therapies. Tissue Engineering Part C: Methods, https://doi.org/10.1089/ten.tec.2023.0037

Background: Allogeneic chondrocyte therapies need to be developed to allow more individuals to be treated with a cell therapy for cartilage repair and to reduce the burden and cost of current two-stage autologous procedures. Up-scale manufacture of c... Read More about The Up-Scale Manufacture of Chondrocytes for Allogeneic Cartilage Therapies.

Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release (2023)
Journal Article
Davies, R., Allen, S., Mennan, C., Platt, M., Wright, K., & Kehoe, O. (2023). Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release. International Journal of Molecular Sciences, 24(11), 9242. https://doi.org/10.3390/ijms24119242

The immunomodulatory properties of MSCs can be recreated using their extracellular vesicles (EVs). Yet, the true capabilities of the MSC EVs cannot be distinguished from contaminating bovine EVs and protein derived from supplemental foetal bovine ser... Read More about Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release.