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Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury (2020)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Osman, A., Roy Chowdhury, J., Kumar, N., …Wright, K. (2020). Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury. Journal of Neurotrauma, 38(3), https://doi.org/10.1089/neu.2020.7144

Neurological outcomes following spinal cord injury (SCI) are currently difficult to predict. Whilst the initial American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade can give an estimate of outcome, the high remaining degree of uncer... Read More about Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury.

The synovial fluid from patients with focal cartilage defects contains mesenchymal stem/stromal cells and macrophages with pro- and anti-inflammatory phenotypes (2020)
Journal Article
Mennan, Hulme, & Wright, K. (2020). The synovial fluid from patients with focal cartilage defects contains mesenchymal stem/stromal cells and macrophages with pro- and anti-inflammatory phenotypes. Osteoarthritis and Cartilage Open, 1-8. https://doi.org/10.1016/j.ocarto.2020.100039

Objective The synovial fluid (SF) of patients with focal cartilage defects contains a population of poorly characterised cells that could have pathophysiological implications in early osteoarthritis and joint tissue repair. We have examined the cells... Read More about The synovial fluid from patients with focal cartilage defects contains mesenchymal stem/stromal cells and macrophages with pro- and anti-inflammatory phenotypes.

Matrix mettaloproteinase-3 (MMP-3) and tissue inhibitors of metalloproteinases-1 (TIMP-1): potential biomarkers to predict the outcome of Autologous Chondrocyte Implantation (2019)
Presentation / Conference
Hulme, C., Roberts, S., Gallacher, P., Jermin, P., Richardson, J., & Wright, K. (2019, October). Matrix mettaloproteinase-3 (MMP-3) and tissue inhibitors of metalloproteinases-1 (TIMP-1): potential biomarkers to predict the outcome of Autologous Chondrocyte Implantation. Paper presented at International Joint and Cartilage Preservation Society (ICRS) 2019, Vancouver, Canada

Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential (2019)
Journal Article
Mennan, C., Garcia, J., McCarthy, H., Owen, S., Perry, J., Wright, K., …Roberts, S. (2019). Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential. Cartilage, 10(4), 467-479. https://doi.org/10.1177/1947603518769714

Objective To assess the phenotype of human articular chondrocytes cultured in normoxia (21% O2) or continuous hypoxia (2% O2). Design Chondrocytes were extracted from patients undergoing total knee replacement (n = 5) and cultured in ~21% (normo... Read More about Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential.

A Preliminary Cohort Study Assessing Routine Blood Analyte Levels and Neurological Outcome after Spinal Cord Injury. (2019)
Journal Article
Brown, S., Harrington, G., Hulme, C., Morris, R., Bennett, A., Tsang, W., …Wright, K. (2020). A Preliminary Cohort Study Assessing Routine Blood Analyte Levels and Neurological Outcome after Spinal Cord Injury. Journal of Neurotrauma, 37(3), https://doi.org/10.1089/neu.2019.6495

There is increasing interest in the identification of biomarkers that could predict neurological outcome following a spinal cord injury (SCI). Although initial American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade is a good indicator... Read More about A Preliminary Cohort Study Assessing Routine Blood Analyte Levels and Neurological Outcome after Spinal Cord Injury..

Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases (2019)
Journal Article
Wang, J., Wright, K., Perry, J., Tins, B., Hopkins, T., Hulme, C., …Richardson, J. (2019). Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases. Cell Transplantation, 28(7), 924 - 931. https://doi.org/10.1177/0963689719845328

Autologous chondrocyte implantation (ACI) has been used to treat cartilage defects for >20 years, with promising clinical outcomes. Here, we report two first-in-man cases (patient A and B) treated with combined autologous chondrocyte and bone marrow... Read More about Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases.

Human umbilical cord mesenchymal stromal cells do not evoke an immune response in the partial medial meniscectomy murine model of osteoarthritis (2019)
Journal Article
Perry, J., Mennan, C., McCarthy, H., Bou-Gharios, G., Hof, R. V. '., Milner, P., …Roberts, S. (2019). Human umbilical cord mesenchymal stromal cells do not evoke an immune response in the partial medial meniscectomy murine model of osteoarthritis. Osteoarthritis and Cartilage, 27(S1), S438-S439. https://doi.org/10.1016/j.joca.2019.02.468

A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells. (2019)
Journal Article
Mennan, C., Garcia, J., Roberts, S., Hulme, C., & Wright, K. (2019). A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells. Stem Cell Research and Therapy, 10, Article 99. https://doi.org/10.1186/s13287-019-1202-4

BACKGROUND: The manufacture of mesenchymal stem/stromal cells (MSCs) for clinical use needs to be cost effective, safe and scaled up. Current methods of expansion on tissue culture plastic are labour-intensive and involve several 'open' procedures.... Read More about A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells..

Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs) (2018)
Presentation / Conference
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., …Wright, K. (2018, July). Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs). Poster presented at Matrix Biology Europe – July 2018 Meeting Celebrating 50 years of Federation of European Connective Tissue Societies Meetings, Manchester, United Kingdom

Introduction: Autologous chondrocyte implantation (ACI) is a cell therapy used to treat cartilage defects and early osteoarthritis. During initial surgery (Stage I), healthy cartilage is harvested from the joint. Chondrocytes are isolated and culture... Read More about Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs).

Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation (2018)
Journal Article
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., …Wright, K. (2018). Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Research and Therapy, 20, Article 87. https://doi.org/10.1186/s13075-018-1573-4

Background Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so that alternativ... Read More about Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation.

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. (2018)
Journal Article
Kuiper, J., & Wright, K. (2018). Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. European cells & materials, 255 - 267. https://doi.org/10.22203/eCM.v035a18

High hopes have been pinned on regenerative medicine strategies in order to prevent the progression of cartilage damage to osteoarthritis, particularly by autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro mo... Read More about Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy..

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy (2018)
Journal Article
Sykes, J., Kuiper, J., Richardson, J., Wright, K., & Kuiper, N. (2018). Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. Osteoarthritis and Cartilage, 26(S1), https://doi.org/10.1016/j.joca.2018.02.221

Purpose High hopes have been pinned on regenerative medicine strategies to meet the challenge of preventing the progression to osteoarthritis, in particular autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro... Read More about Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy.

Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation (2018)
Journal Article
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., …Wright, K. (2018). Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation. Osteoarthritis and Cartilage, 26(S1), S167. https://doi.org/10.1016/j.joca.2018.02.363

Background: Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so that alternat... Read More about Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation.

Assessment of candidate predictive protein biomarkers for microfracture and osteotomy (2018)
Journal Article
Hulme, C., Richardson, J., Gallacher, P., Roberts, S., & Wright, K. (2018). Assessment of candidate predictive protein biomarkers for microfracture and osteotomy. Osteoarthritis and Cartilage, 26(S1), S191-S192. https://doi.org/10.1016/j.joca.2018.02.410

PlumX Metrics Purpose: Biomarkers that can predict clinical outcome for surgeries to prevent the progression of osteoarthritis (OA) are needed to ensure patients can be better stratified to receive the most appropriate treatment. We have previousl... Read More about Assessment of candidate predictive protein biomarkers for microfracture and osteotomy.

Assessing The Characteristics Of Human Mesenchymal Stromal Cells Derived From Bone Marrow And Umbilical Cord Following Expansion In The Quantum® Hollow-fibre Bioreactor System (2018)
Journal Article
Mennan, C., Roberts, S., Garcia, J., Hulme, C., & Wright, K. (2018). Assessing The Characteristics Of Human Mesenchymal Stromal Cells Derived From Bone Marrow And Umbilical Cord Following Expansion In The Quantum® Hollow-fibre Bioreactor System. Osteoarthritis and Cartilage, 26(S1), S146-S147. https://doi.org/10.1016/j.joca.2018.02.316

No abstract

Autologous chondrocyte implantation- derived synovial fluids display distinct responder and non-responder proteomic profiles (2017)
Journal Article
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., …Wright, K. (2017). Autologous chondrocyte implantation- derived synovial fluids display distinct responder and non-responder proteomic profiles. Arthritis Research and Therapy, 19, Article 150. https://doi.org/10.1186/s13075-017-1336-7

Background Autologous chondrocyte implantation (ACI) can be used in the treatment of focal cartilage injuries to prevent the onset of osteoarthritis (OA). However, we are yet to understand fully why some individuals do not respond well to this interv... Read More about Autologous chondrocyte implantation- derived synovial fluids display distinct responder and non-responder proteomic profiles.

Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation (2017)
Journal Article
Garcia, J., Hulme, C., Roberts, S., Richardson, J., Kuiper, J., & Wright, K. (2017). Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation. International Journal of Experimental Pathology, 98(3), A23

Introduction Autologous chondrocyte implantation (ACI) and microfracture are both used in the treatment of cartilage injuries. Previous findings suggest that the efficacy of these two therapies is similar in terms of short-term clinical outcome, h... Read More about Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation.

Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. (2017)
Journal Article
Richardson, J. B., Wright, K. T., Wales, J., Herman Kuiper, J., McCarthy, H. S., Gallacher, P., …Roberts, S. (2017). Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. Regenerative Medicine, 12(5), 493-501. https://doi.org/10.2217/rme-2017-0032

AIM: The main aim of this trial is to test the safety and efficacy of autologous stromal/stem cells, chondrocytes or the two combined in the treatment of knee cartilage defects. PATIENTS & METHODS: Patients with symptomatic chondral/osteochondral def... Read More about Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design..

Facilitating the operational readiness of the NHS for the in-house manufacture and delivery of autologous cell therapy (2017)
Presentation / Conference
Ziya, S., Medcalf, N., El, A., & Wright, K. (2017, June). Facilitating the operational readiness of the NHS for the in-house manufacture and delivery of autologous cell therapy. Poster presented at ISCT 2017 Annual Meeting, London, UK

Introduction: Cell-based therapies (CBTs) have been shown to confer regenerative capacity in various pathologies. The production of such treatments require a range of business models. These business models either align with or disrupt the current c... Read More about Facilitating the operational readiness of the NHS for the in-house manufacture and delivery of autologous cell therapy.