Skip to main content

Research Repository

Advanced Search

All Outputs (9)

Human adipose tissue-derived mesenchymal stem/stromal cells adhere to and inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa (2018)
Journal Article
Wood, C. R., Al Dhahri, D., Al Delfi, I., Pickles, N. A., Sammons, R. L., Worthington, T., Wright, K. T., & Johnson, W. E. B. (2018). Human adipose tissue-derived mesenchymal stem/stromal cells adhere to and inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa. Journal of Medical Microbiology, 67(12), 1789-1795. https://doi.org/10.1099/jmm.0.000861

Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs) (2018)
Presentation / Conference Contribution
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., Peffers, M., Shirran, S., Botting, C., & Wright, K. (2018, July). Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs). Poster presented at Matrix Biology Europe – July 2018 Meeting Celebrating 50 years of Federation of European Connective Tissue Societies Meetings, Manchester, United Kingdom

Introduction: Autologous chondrocyte implantation (ACI) is a cell therapy used to treat cartilage defects and early osteoarthritis. During initial surgery (Stage I), healthy cartilage is harvested from the joint. Chondrocytes are isolated and culture... Read More about Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs).

Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation (2018)
Journal Article
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., Peffers, M., Shirran, S., Botting, C., & Wright, K. (2018). Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Research and Therapy, 20, Article 87. https://doi.org/10.1186/s13075-018-1573-4

Background
Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so that alternativ... Read More about Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation.

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. (2018)
Journal Article
Kuiper, J., & Wright, K. (2018). Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. European cells & materials, 255 - 267. https://doi.org/10.22203/eCM.v035a18

High hopes have been pinned on regenerative medicine strategies in order to prevent the progression of cartilage damage to osteoarthritis, particularly by autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro mo... Read More about Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy..

Assessment of candidate predictive protein biomarkers for microfracture and osteotomy (2018)
Presentation / Conference Contribution
Hulme, C., Richardson, J., Gallacher, P., Roberts, S., & Wright, K. Assessment of candidate predictive protein biomarkers for microfracture and osteotomy. Presented at 2018 OARSI World Congress on Osteoarthritis (26-29 April 2018), ACC Congress Center Liverpool, United Kingdom

PlumX Metrics

Purpose: Biomarkers that can predict clinical outcome for surgeries to prevent the progression of osteoarthritis (OA) are needed to ensure patients can be better stratified to receive the most appropriate treatment. We have previousl... Read More about Assessment of candidate predictive protein biomarkers for microfracture and osteotomy.

Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation (2018)
Presentation / Conference Contribution
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., Peffers, M., Shirran, S., Botting, C., & Wright, K. Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation

Background: Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be
fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so
that alternat... Read More about Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation.

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy (2018)
Presentation / Conference Contribution
Sykes, J., Kuiper, J., Richardson, J., Wright, K., & Kuiper, N. Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. Presented at 2018 OARSI World Congress on Osteoarthritis (26-29 April 2018), ACC Congress Center Liverpool, United Kingdom

Purpose
High hopes have been pinned on regenerative medicine strategies to meet the challenge of preventing the progression to osteoarthritis, in particular autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro... Read More about Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy.