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All Outputs (18)

Predictors of outcome following an epidural steroid injection for disc-related sciatica: a Delphi consensus study. (2024)
Journal Article
Stynes, S., Foster, N., O'Dowd, J., Ostelo, R., & Konstantinou, K. (in press). Predictors of outcome following an epidural steroid injection for disc-related sciatica: a Delphi consensus study. European Spine Journal, https://doi.org/10.1007/s00586-024-08342-2

Trial data shows modest reductions in leg pain, disability and surgery avoidance following epidural steroid injections (ESI) for severe sciatica. Despite their common use, there is no clear evidence about which patients are more likely to benefit fro... Read More about Predictors of outcome following an epidural steroid injection for disc-related sciatica: a Delphi consensus study..

Predictors of outcome in sciatica patients following an epidural steroid injection: the POiSE prospective observational cohort study protocol (2023)
Journal Article
Stynes, S., Snell, K. I., Riley, R. D., Konstantinou, K., Cherrington, A., Daud, N., …Foster, N. E. (2023). Predictors of outcome in sciatica patients following an epidural steroid injection: the POiSE prospective observational cohort study protocol. BMJ Open, 13(11), Article e077776. https://doi.org/10.1136/bmjopen-2023-077776

Introduction: Sciatica can be very painful and, in most cases, is due to pressure on a spinal nerve root from a disc herniation with associated inflammation. For some patients, the pain persists, and one management option is a spinal epidural steroi... Read More about Predictors of outcome in sciatica patients following an epidural steroid injection: the POiSE prospective observational cohort study protocol.

Systematic Review of Decision Analytic Modelling in Economic Evaluations of Low Back Pain and Sciatica. (2019)
Journal Article
Hall, J. A., Konstantinou, K., Lewis, M., Oppong, R., Ogollah, R., & Jowett, S. (2019). Systematic Review of Decision Analytic Modelling in Economic Evaluations of Low Back Pain and Sciatica. Applied Health Economics and Health Policy, 17, 467-491. https://doi.org/10.1007/s40258-019-00471-w

BACKGROUND: Low back pain (LBP) and sciatica place significant burden on individuals and healthcare systems, with societal costs alone likely to be in excess of £15 billion. Two recent systematic reviews for LBP and sciatica identified a shortage of... Read More about Systematic Review of Decision Analytic Modelling in Economic Evaluations of Low Back Pain and Sciatica..

Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm (2019)
Journal Article
Konstantinou, K., Dunn, K., Windt, D., Ogollah, R., Jasani, V., & Foster, N. (2019). Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-019-2686-x

Background Sciatica is a painful condition managed by a stepped care approach for most patients. Currently, there are no decision-making tools to guide matching care pathways for patients with sciatica without evidence of serious pathology, early in... Read More about Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm.

Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis (2019)
Journal Article
Kigozi, J., Konstantinou, K., Ogollah, R., Dunn, K., Lewis, M., & Jowett, S. (2019). Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis. BMC Health Services Research, https://doi.org/10.1186/s12913-019-4257-0

Background There is limited research on the economic burden of low back-related leg pain, including sciatica. The aim of this study was to describe healthcare resource utilisation and factors associated with cost and health outcomes in primary care... Read More about Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis.

Inflammatory biomarkers do not distinguish between patients with sciatica and referred leg pain within a primary care population: results from a nested study within the ATLAS cohort (2019)
Journal Article
Hider, S. L., Konstantinou, K., Hay, E. M., Glossop, J., & Mattey, D. L. (2019). Inflammatory biomarkers do not distinguish between patients with sciatica and referred leg pain within a primary care population: results from a nested study within the ATLAS cohort. BMC Musculoskeletal Disorders, 20, Article 202. https://doi.org/10.1186/s12891-019-2604-2

Background There is increasing interest in the role of pro-inflammatory cytokines in the pathogenesis of sciatica and whether these could be potential targets for treatment. We sought to investigate serum biomarker levels in patients with low back-r... Read More about Inflammatory biomarkers do not distinguish between patients with sciatica and referred leg pain within a primary care population: results from a nested study within the ATLAS cohort.

Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC) (2018)
Journal Article
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., …Wilkinson, C. (2018). Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC). Trials, 19, Article 408. https://doi.org/10.1186/s13063-018-2801-6

BACKGROUND: Adalimumab, a biological treatment targeting tumour necrosis factor a, might be useful in sciatica. This paper describes the challenges faced when developing a new treatment pathway for a randomised controlled trial of adalimumab for peop... Read More about Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC).

Clinical diagnostic model for sciatica developed in primary care patients with low back-related leg pain (2018)
Journal Article
Stynes, S., Konstantinou, K., Ogollah, R., Hay, E., & Dunn, K. (2018). Clinical diagnostic model for sciatica developed in primary care patients with low back-related leg pain. PloS one, 1 -14. https://doi.org/10.1371/journal.pone.0191852

Background Identification of sciatica may assist timely management but can be challenging in clinical practice. Diagnostic models to identify sciatica have mainly been developed in secondary care settings with conflicting reference standard selection... Read More about Clinical diagnostic model for sciatica developed in primary care patients with low back-related leg pain.

Novel approach to characterising individuals with low back-related leg pain: cluster identification with latent class analysis and 12-month follow-up. (2018)
Journal Article
Stynes, S., Konstantinou, K., Ogollah, R., Hay, E. M., & Dunn, K. M. (2018). Novel approach to characterising individuals with low back-related leg pain: cluster identification with latent class analysis and 12-month follow-up. PAIN, 159(4), https://doi.org/10.1097/j.pain.0000000000001147

Traditionally, low back-related leg pain (LBLP) is diagnosed clinically as referred leg pain or sciatica (nerve root involvement). However, within the spectrum of LBLP, we hypothesised that there may be other unrecognised patient subgroups. This stud... Read More about Novel approach to characterising individuals with low back-related leg pain: cluster identification with latent class analysis and 12-month follow-up..

Characteristics of patients with low back and leg pain seeking treatment in primary care: baseline results from the ATLAS cohort study. (2016)
Journal Article
Konstantinou, K., Dunn, K., Ogollah, R., Vogel, S., & Hay, E. (2016). Characteristics of patients with low back and leg pain seeking treatment in primary care: baseline results from the ATLAS cohort study. BMC Musculoskeletal Disorders, 332. https://doi.org/10.1186/s12891-015-0787-8

Background Patients with back pain radiating to the leg(s) report worse symptoms and poorer recovery than those with back pain alone. Robust evidence regarding their epidemiological profile is lacking from primary care, the setting where most of the... Read More about Characteristics of patients with low back and leg pain seeking treatment in primary care: baseline results from the ATLAS cohort study..

FRI0556 Are Serum Biomarker Levels Associated with Sciatica? (2016)
Presentation / Conference
Hider, S., Konstantinou, K., Mattey, D., & Hay, E. (2016, June). FRI0556 Are Serum Biomarker Levels Associated with Sciatica?. Poster presented at Annals of the Rheumatic Diseases (EULAR 2016), London, United Kingdom

Background Pro-inflammatory cytokines released from the intervertebral disc are considered key in the pathogenesis of sciatica. There is increasing interest in whether biologics such as anti-TNF therapies could be used for treatment of sciatica. Data... Read More about FRI0556 Are Serum Biomarker Levels Associated with Sciatica?.

Reliability among clinicians diagnosing low back-related leg pain. (2015)
Journal Article
Stynes, S., Konstantinou, K., Dunn, K., Lewis, M., & Hay, E. (2015). Reliability among clinicians diagnosing low back-related leg pain. European Spine Journal, 25, 2734–2740. https://doi.org/10.1007/s00586-015-4359-2

PURPOSE: To investigate agreement and reliability among clinicians when diagnosing low back-related leg pain (LBLP) in primary care consulters. METHODS: Thirty-six patients were assessed by one of six physiotherapists and diagnosed as having either l... Read More about Reliability among clinicians diagnosing low back-related leg pain..

Stratified care for patients with sciatica and suspected sciatica in primary care: the scopic trial protocol (scopic-sciatica outcomes in primary care) (2015)
Presentation / Conference
Foster, N., Konstantinou, K., Beardmore, R., Dunn, K., Lewis, M., Bartlam, B., …Hay, E. (2015, November). Stratified care for patients with sciatica and suspected sciatica in primary care: the scopic trial protocol (scopic-sciatica outcomes in primary care). Poster presented at 3rd International Clinical Trials Methodology Conference, Glasgow

AGREEMENT AMONG THERAPISTS WHEN DIAGNOSING LOW BACK-RELATED LEG PAIN (2014)
Journal Article
Stynes, S., Konstantinou, K., Dunn, K., Lewis, M., & Hay, E. (2014). AGREEMENT AMONG THERAPISTS WHEN DIAGNOSING LOW BACK-RELATED LEG PAIN. Orthopaedic Proceedings, 96-B(S4), 4-4

Background Pain with radiation to the leg is a common presentation in back pain patients. Radiating leg pain is either referred pain or radicular, commonly described as sciatica. Clinically distinguishing between these types of leg pain is recognize... Read More about AGREEMENT AMONG THERAPISTS WHEN DIAGNOSING LOW BACK-RELATED LEG PAIN.

Prognostic factors in non-surgically treated sciatica: a systematic review (2011)
Journal Article
Ashworth, J., Konstantinou, K., & Dunn, K. M. (2011). Prognostic factors in non-surgically treated sciatica: a systematic review. BMC Musculoskeletal Disorders, 208 - ?. https://doi.org/10.1186/1471-2474-12-208

BACKGROUND: When present sciatica is considered an obstacle to recovery in low back pain patients, yet evidence is limited regarding prognostic factors for persistent disability in this patient group. The aim of this study is to describe and summaris... Read More about Prognostic factors in non-surgically treated sciatica: a systematic review.