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Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource. (2021)
Journal Article
Mamas. (2021). Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource. https://doi.org/10.1136/bmj.n826

OBJECTIVE: To describe a novel England-wide electronic health record (EHR) resource enabling whole population research on covid-19 and cardiovascular disease while ensuring data security and privacy and maintaining public trust. DESIGN: Data resource... Read More about Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource..

Derivation and validation of a clinical model to predict death or cardiac hospitalizations while on the cardiac surgery waitlist (2021)
Journal Article
Mamas. (2021). Derivation and validation of a clinical model to predict death or cardiac hospitalizations while on the cardiac surgery waitlist. Canadian Medical Association Journal, E1333 - E1340

Background: Waitlist management is a global challenge. For patients with severe cardiovascular diseases awaiting cardiac surgery, prolonged wait times are associated with unplanned hospitalizations. To facilitate evidence-based resource allocation, w... Read More about Derivation and validation of a clinical model to predict death or cardiac hospitalizations while on the cardiac surgery waitlist.

Elixhauser outperformed Charlson comorbidity index in prognostic value after ACS: insights from a national registry. (2021)
Journal Article
Mamas. (2021). Elixhauser outperformed Charlson comorbidity index in prognostic value after ACS: insights from a national registry. Journal of Clinical Epidemiology, 26-35. https://doi.org/10.1016/j.jclinepi.2021.08.025

OBJECTIVE: To compare the performance of risk adjustment models using the Elixhauser and Charlson comorbidity scores in predicting in-hospital outcomes of ACS patients from a nationwide administrative database. STUDY DESIGN AND SETTING: All hospitali... Read More about Elixhauser outperformed Charlson comorbidity index in prognostic value after ACS: insights from a national registry..

Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia (2021)
Journal Article
Mamas. (2021). Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia. Metabolomics, https://doi.org/10.1007/s11306-021-01827-x

Introduction Acute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic patterns. Advances in metabolomics have extended our capabilities to define these metabolic perturbati... Read More about Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia.

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock. (2021)
Journal Article
Mamas, M. (2021). Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock. https://doi.org/10.3791/62140

The left atrial to femoral artery bypass (LAFAB) system is a mechanical circulatory support (MCS) device used in cardiogenic shock (CS) that bypasses the left ventricle by draining blood from the left atrium (LA) and returning it to the systemic arte... Read More about Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock..

Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention. (2021)
Journal Article
Bhatt, D. L., Carlos Kaski, J., Delaney, S., Alasnag, M., Andreotti, F., Angiolillo, D. J., …Valgimigli, M. (2021). Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention. International Journal of Cardiology, 1 - 8. https://doi.org/10.1016/j.ijcard.2021.05.012

AIMS: Choosing an antiplatelet strategy in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) at high bleeding risk (HBR), undergoing post-percutaneous coronary intervention (PCI), is complex. We used a unique open-source appro... Read More about Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention..

Ambulatory intravenous furosemide for decompensated heart failure: safe, feasible, and effective (2021)
Journal Article
Ahmed, F. Z., Taylor, J. K., John, A. V., Khan, M. A., Zaidi, A. M., Mamas, M. A., …Cunnington, C. (2021). Ambulatory intravenous furosemide for decompensated heart failure: safe, feasible, and effective. ESC Heart Failure, 8(5), 3906-3916. https://doi.org/10.1002/ehf2.13368

AIMS: This study aims to establish the feasibility, safety, and efficacy of outpatient intravenous (IV) diuretic treatment for the management of decompensated heart failure (HF) for patients enrolled in the HeartFailure@Home service. METHODS AND RESU... Read More about Ambulatory intravenous furosemide for decompensated heart failure: safe, feasible, and effective.

Intravascular imaging-guided intracoronary lithotripsy: First real-world experience (2021)
Journal Article
Sinclair, H., Fan, L., Fahy, E., Shahid, F., Ratib, K., Nolan, J., …Ahmed, J. (2021). Intravascular imaging-guided intracoronary lithotripsy: First real-world experience. Health Science Reports, 4(3), Article e307. https://doi.org/10.1002/hsr2.307

Background and Aims: Coronary calcification remains a significant challenge for the contemporary interventional cardiologist. We aim to describe the use of intravascular lithotripsy (IVL) in a range of real-world settings. Methods: A retrospective tw... Read More about Intravascular imaging-guided intracoronary lithotripsy: First real-world experience.

Acute Pulmonary Embolism During Pregnancy and Puerperium: National Trends and In-Hospital Outcomes. (2021)
Journal Article
Mamas. (2021). Acute Pulmonary Embolism During Pregnancy and Puerperium: National Trends and In-Hospital Outcomes. Mayo Clinic Proceedings, 2102 - 2113. https://doi.org/10.1016/j.mayocp.2021.01.015

OBJECTIVE: To investigate the trend and outcomes of acute pulmonary embolism (PE) during pregnancy and puerperium using a large national database. PATIENTS AND METHODS: The National Inpatient Sample was queried to identify pregnancy-related hospitali... Read More about Acute Pulmonary Embolism During Pregnancy and Puerperium: National Trends and In-Hospital Outcomes..

Excess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study. (2021)
Journal Article
Mamas. (2021). Excess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study. The Lancet Regional Health Europe, 100144 - ?. https://doi.org/10.1016/j.lanepe.2021.100144

BACKGROUND: Excess deaths during the COVID-19 pandemic compared with those expected from historical trends have been unequally distributed, both geographically and socioeconomically. Not all excess deaths have been directly related to COVID-19 infect... Read More about Excess deaths from COVID-19 and other causes by region, neighbourhood deprivation level and place of death during the first 30 weeks of the pandemic in England and Wales: A retrospective registry study..

Thrombolysis in acute ischaemic stroke patients with chronic kidney disease. (2021)
Journal Article
Mamas, M. (2021). Thrombolysis in acute ischaemic stroke patients with chronic kidney disease. https://doi.org/10.1111/ane.13513

OBJECTIVE: We aimed to determine whether chronic kidney disease (CKD) is associated with adverse in-hospital outcomes after acute ischaemic stroke (AIS) and whether this association is dependent on thrombolysis administration. METHODS: 885,537 record... Read More about Thrombolysis in acute ischaemic stroke patients with chronic kidney disease..

In-Hospital Complications in Pregnant Women With Current or Historical Cancer Diagnoses (2021)
Journal Article
Wu, P., P. Jordan, K., A. Chew-Graham, C., O. Mohamed, M., Barac, A., P. Lundberg, G., …A. Mamas, M. (2021). In-Hospital Complications in Pregnant Women With Current or Historical Cancer Diagnoses. Mayo Clinic Proceedings, 96(11), 2779-2792. https://doi.org/10.1016/j.mayocp.2021.03.038

Objective To assess the temporal trends, patient characteristics and comorbidities, and in-hospital cardiovascular and obstetric complications and outcomes of pregnant women with current or historical cancer diagnosis at the time of admission for de... Read More about In-Hospital Complications in Pregnant Women With Current or Historical Cancer Diagnoses.

Operator Volumes and In-Hospital Outcomes: An Analysis of 7,740 Rotational Atherectomy Procedures From the BCIS National Database. (2021)
Journal Article
Mamas. (2021). Operator Volumes and In-Hospital Outcomes: An Analysis of 7,740 Rotational Atherectomy Procedures From the BCIS National Database. JACC. Cardiovascular interventions, 1423 - 1430. https://doi.org/10.1016/j.jcin.2021.04.034

OBJECTIVES: The aims of this study were to use a national percutaneous coronary intervention (PCI) registry to study temporal changes in procedure volumes of PCI using rotational atherectomy (ROTA-PCI), the patient and procedural factors associated w... Read More about Operator Volumes and In-Hospital Outcomes: An Analysis of 7,740 Rotational Atherectomy Procedures From the BCIS National Database..

Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020 (2021)
Journal Article
Mamas. (2021). Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020

Background Deaths in the first year of the COVID-19 pandemic in England & Wales have been shown to be unevenly distributed socioeconomically and geographically. However, the full scale of inequalities may have been underestimated as most measures of... Read More about Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020.

Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. (2021)
Journal Article
Mamas, M., & Mallen, C. (2021). Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. Research Square, https://doi.org/10.21203/rs.3.rs-670522/v1

Objectives: To examine the association between ß -blocker prescription and knee or hip total joint replacement (TJR) in a UK primary-care population with incident knee or hip osteoarthritis (OA). Methods: Cohort study using data from the Clinical P... Read More about Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink..

Association between serum secretory phospholipase A2 and risk of ischemic stroke. (2021)
Journal Article
Mamas. (2021). Association between serum secretory phospholipase A2 and risk of ischemic stroke. European Journal of Neurology, https://doi.org/10.1111/ene.15004

BACKGROUND AND PURPOSE: Previous literature has demonstrated an association between high serum levels of type-II secretory phospholipase A2 (sPLA2) concentration and an increased risk of coronary artery disease. However, such association has not been... Read More about Association between serum secretory phospholipase A2 and risk of ischemic stroke..

Sex Differences in Outcomes Following Left Atrial Appendage Closure. (2021)
Journal Article
Sanjoy, S. S., Choi, Y., Sparrow, R. T., Baron, S. J., Abbott, J. D., Azzalini, L., …Bagur, R. (2021). Sex Differences in Outcomes Following Left Atrial Appendage Closure. https://doi.org/10.1016/j.mayocp.2020.11.031

OBJECTIVE: To evaluate the effects of female sex on in-hospital outcomes and to provide estimates for sex-specific prediction models of adverse outcomes following left atrial appendage closure (LAAC). PATIENTS AND METHODS: Cohort-based observational... Read More about Sex Differences in Outcomes Following Left Atrial Appendage Closure..