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Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study. (2022)
Journal Article
Mamas. (2022). Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study. PLoS Medicine, e1004003 - ?. https://doi.org/10.1371/journal.pmed.1004003

BACKGROUND: Atrial fibrillation (AF) is an important risk factor for ischaemic stroke, and AF incidence is expected to increase. Guidelines recommend using oral anticoagulants (OACs) to prevent the development of stroke. However, studies have reporte... Read More about Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study..

RISK OF VENOUS THROMBOEMBOLISM AFTER GOUT FLARES (2022)
Presentation / Conference
Cipolletta, E., Nakafero, G., Mamas, M., Avery, A., Tata, L., & Abhishek, A. (2022, June). RISK OF VENOUS THROMBOEMBOLISM AFTER GOUT FLARES. Poster presented at EULAR 2022 European Congress of Rheumatology, Copenhagen, Denmark

Background Several population-based cohort studies have reported an increased risk of venous thromboembolism (VTE) in gout patients. However, none of these studies has investigated the temporal relationship between gout flares and VTE. Objectives... Read More about RISK OF VENOUS THROMBOEMBOLISM AFTER GOUT FLARES.

The collateral damage of COVID-19 on cardiovascular services: a meta-analysis (2022)
Journal Article
Mamas. (2022). The collateral damage of COVID-19 on cardiovascular services: a meta-analysis. European Heart Journal, https://doi.org/10.1093/eurheartj/ehac227

Aims The effect of the COVID-19 pandemic on care and outcomes across non-COVID-19 cardiovascular (CV) diseases is unknown. A systematic review and meta-analysis was performed to quantify the effect and investigate for variation by CV disease, geograp... Read More about The collateral damage of COVID-19 on cardiovascular services: a meta-analysis.

Baseline platelet count in percutaneous coronary intervention: a dose-response meta-analysis. (2022)
Journal Article
Mamas. (2022). Baseline platelet count in percutaneous coronary intervention: a dose-response meta-analysis. Heart, https://doi.org/10.1136/heartjnl-2022-320910

OBJECTIVES: The nature of the relationship between baseline platelet count and clinical outcomes following percutaneous coronary intervention (PCI) is unclear. We undertook dose-response and pairwise meta-analyses to better describe the prognostic va... Read More about Baseline platelet count in percutaneous coronary intervention: a dose-response meta-analysis..

Temporal patterns, characteristics, and predictors of clinical outcomes in patients undergoing percutaneous coronary intervention for stent thrombosis. (2022)
Journal Article
Mohamed, M. O., Sirker, A., Chieffo, A., Avanzas, P., Nolan, J., Rashid, M., …Mamas, M. (2022). Temporal patterns, characteristics, and predictors of clinical outcomes in patients undergoing percutaneous coronary intervention for stent thrombosis. EuroIntervention, 18(9), https://doi.org/10.4244/EIJ-D-22-00049

BACKGROUND: There are limited data on the outcomes of percutaneous coronary intervention (PCI) following stent thrombosis (ST) and differences exist based on timing. AIMS: Our aim was to study the rates of PCI procedures for an ST indication among al... Read More about Temporal patterns, characteristics, and predictors of clinical outcomes in patients undergoing percutaneous coronary intervention for stent thrombosis..

Treatment Effect of Percutaneous Coronary Intervention in Dialysis Patients With ST-Elevation Myocardial Infarction. (2022)
Journal Article
Mamas, M. (2022). Treatment Effect of Percutaneous Coronary Intervention in Dialysis Patients With ST-Elevation Myocardial Infarction. American Journal of Kidney Diseases, 832 - 840. https://doi.org/10.1053/j.ajkd.2021.08.023

RATIONALE & OBJECTIVE: Patients receiving maintenance dialysis have higher mortality after primary percutaneous coronary intervention (pPCI) than patients not receiving dialysis. Whether pPCI confers a benefit to patients receiving dialysis that is s... Read More about Treatment Effect of Percutaneous Coronary Intervention in Dialysis Patients With ST-Elevation Myocardial Infarction..

Impact of pre-existing vascular disease on clinical outcomes (2022)
Journal Article
Weight, N., Moledina, S., Zoccai, G. B., Zaman, S., Smith, T., Siller-Matula, J., …Mamas, M. A. (2022). Impact of pre-existing vascular disease on clinical outcomes. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcac026

AIMS: Little is known about the outcomes and processes of care of patients with non ST-segment myocardial infarction (NSTEMI) who present with 'polyvascular' disease. METHODS AND RESULTS: We analysed 287,279 NSTEMI patients using the Myocardial Infar... Read More about Impact of pre-existing vascular disease on clinical outcomes.

Ethnicity in Complex High-Risk but Indicated Percutaneous Coronary Intervention Types and Outcomes. (2022)
Journal Article
Rashid, & Mamas. (2022). Ethnicity in Complex High-Risk but Indicated Percutaneous Coronary Intervention Types and Outcomes. American Journal of Cardiology, 26-37. https://doi.org/10.1016/j.amjcard.2022.03.056

Complex High-risk but indicated Percutaneous coronary interventions (CHiPs) is increasingly common in contemporary practice. However, data on ethnic differences in CHiP types, outcomes, and trends in patients with stable angina are limited; this is p... Read More about Ethnicity in Complex High-Risk but Indicated Percutaneous Coronary Intervention Types and Outcomes..

Mortality after transcatheter aortic valve replacement for aortic stenosis among patients with malignancy: a systematic review and meta-analysis (2022)
Journal Article
Mamas. (2022). Mortality after transcatheter aortic valve replacement for aortic stenosis among patients with malignancy: a systematic review and meta-analysis. BMC Cardiovascular Disorders, https://doi.org/10.1186/s12872-022-02651-4

Background: With advancements in cancer treatment, the life expectancy of oncology patients has improved. Thus, transcatheter aortic valve replacement (TAVR) may be considered as a feasible option for oncology patients with severe symptomatic aortic... Read More about Mortality after transcatheter aortic valve replacement for aortic stenosis among patients with malignancy: a systematic review and meta-analysis.

Bempedoic acid and its role in contemporary management of hyperlipidemia in atherosclerosis. (2022)
Journal Article
Mamas. (2022). Bempedoic acid and its role in contemporary management of hyperlipidemia in atherosclerosis. https://doi.org/10.1080/07853890.2022.2059559

Atherosclerotic heart disease is the leading cause of mortality and morbidity in the USA. Low density lipoprotein (LDL) has been the target for many hypolipidemic agents to modify atherosclerotic risk. Bempedoic acid is a novel hypolipidemic drug tha... Read More about Bempedoic acid and its role in contemporary management of hyperlipidemia in atherosclerosis..

Body Mass Index and Mortality, Recurrence and Readmission after Myocardial Infarction: Systematic Review and Meta-Analysis (2022)
Journal Article
Mamas. (2022). Body Mass Index and Mortality, Recurrence and Readmission after Myocardial Infarction: Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 2581 - 2581. https://doi.org/10.3390/jcm11092581

The following study aimed to systematically review and meta-analyse the literature on the relations between markers of nutritional status and long-term mortality, recurrence and all-cause hospital readmission following myocardial infarction (MI). Med... Read More about Body Mass Index and Mortality, Recurrence and Readmission after Myocardial Infarction: Systematic Review and Meta-Analysis.

Differential Impact of Type 1 and Type 2 Diabetes Mellitus on Outcomes Among 1.4 Million US Patients Undergoing Percutaneous Coronary Intervention. (2022)
Journal Article
Mamas. (2022). Differential Impact of Type 1 and Type 2 Diabetes Mellitus on Outcomes Among 1.4 Million US Patients Undergoing Percutaneous Coronary Intervention. https://doi.org/10.1016/j.carrev.2021.08.018

BACKGROUND: The aim was to determine the impact of diabetes mellitus (DM) on outcomes after percutaneous coronary intervention (PCI). There is limited data on the impact of DM and its subtypes among patients who underwent PCI during hospitalization.... Read More about Differential Impact of Type 1 and Type 2 Diabetes Mellitus on Outcomes Among 1.4 Million US Patients Undergoing Percutaneous Coronary Intervention..

Temporal trends and patterns in atrial fibrillation incidence: a population-based study of 3·4 million individuals (2022)
Journal Article
Mamas. (2022). Temporal trends and patterns in atrial fibrillation incidence: a population-based study of 3·4 million individuals. The Lancet Regional Health Europe, https://doi.org/10.1016/j.lanepe.2022.100386

Background Population-based studies of atrial fibrillation (AF) incidence are needed to inform health-service planning, but evidence is conflicting. We assessed trends of AF incidence in a large general population cohort from England. Methods We used... Read More about Temporal trends and patterns in atrial fibrillation incidence: a population-based study of 3·4 million individuals.

P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study (2022)
Journal Article
Mason, K. J., Jordan, K. P., Achana, F. A., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. J. (2022). P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study. Rheumatology, 61(S1), https://doi.org/10.1093/rheumatology/keac133.180

Abstract Background/Aims There is some evidence of an increased risk of cardiovascular disease in patients with painful musculoskeletal conditions, but it is unclear if musculoskeletal pain also worsens its prognosis. The aim was to determine whethe... Read More about P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study.

Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis. (2022)
Journal Article
Sokhal, B., Matetić, A., Bharadwaj, A., Helliwell, T., Abhishek, A., Mallen, C., …Mamas, M. (2022). Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis. American Journal of Cardiology, 12-19. https://doi.org/10.1016/j.amjcard.2022.03.034

This study analyzed the characteristics, management, and outcomes of patients with polymyalgia rheumatica (PMR) hospitalized with acute myocardial infarction (AMI), including sensitivity analysis for presence of giant cell arteritis (GCA). Using the... Read More about Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis..

Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019 (2022)
Journal Article
Mamas. (2022). Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcac016

Aims: We report disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, and cancer site. Methods and results: We used the Multiple Cause of Death databas... Read More about Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019.

Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis (2022)
Journal Article
Peel, J. K., Miranda, R. N., Naimark, D., Woodward, G., Mamas, M. A., Madan, M., & Wijeysundera, H. C. (2022). Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis. Journal of the American Heart Association, 11(8), Article ARTN e025085. https://doi.org/10.1161/jaha.121.025085

Background Transcatheter aortic valve implantation (TAVI) is a minimally invasive therapy for patients with severe aortic stenosis, which has become standard of care. The objective of this study was to determine the maximum cost-effective investment... Read More about Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis.

Evidence for overuse of cardiovascular healthcare services in high-income countries: protocol for a systematic review and meta-analysis. (2022)
Journal Article
Mamas. (2022). Evidence for overuse of cardiovascular healthcare services in high-income countries: protocol for a systematic review and meta-analysis. BMJ Open, e053920 - ?. https://doi.org/10.1136/bmjopen-2021-053920

INTRODUCTION: Overuse of cardiovascular healthcare services, defined as the provision of low-value (ineffective, harmful, cost-ineffective) tests, medications and procedures, may be common and associated with increased patient harm and health system... Read More about Evidence for overuse of cardiovascular healthcare services in high-income countries: protocol for a systematic review and meta-analysis..