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Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study (2022)
Journal Article
Mamas, M. A., Sanghavi, R., Pana, T. A., Mamayusupova, H., Maidment, I., Fox, C., …Myint, P. K. (2022). Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study. British Journal of Clinical Pharmacology, 88(7), 3297-3306. https://doi.org/10.1111/bcp.15261

Background Higher medication anticholinergic burden is associated with increased risk of cardiovascular disease and cognitive decline. A mechanistic pathway has not been established. We aimed to determine whether inflammation may mediate these assoc... Read More about Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study.

Is There a Role for Triple Therapy After ACS? (2022)
Journal Article
Mamas. (2022). Is There a Role for Triple Therapy After ACS?. Current Cardiology Reports, 191 - 200. https://doi.org/10.1007/s11886-022-01634-3

PURPOSE OF REVIEW: The optimal antithrombotic strategy in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) remains the subject of controversy. In this article, we review the current evidence for the use of tr... Read More about Is There a Role for Triple Therapy After ACS?.

Quality of acute myocardial infarction care in England and Wales during the COVID-19 pandemic: linked nationwide cohort study. (2022)
Journal Article
Aktaa, S., Yadegarfar, M. E., Wu, J., Rashid, M., de Belder, M., Deanfield, J., …Gale, C. P. (2022). Quality of acute myocardial infarction care in England and Wales during the COVID-19 pandemic: linked nationwide cohort study. https://doi.org/10.1136/bmjqs-2021-013040

BACKGROUND AND OBJECTIVE: The impact of the COVID-19 pandemic on the quality of care for patients with acute myocardial infarction (AMI) is uncertain. We aimed to compare quality of AMI care in England and Wales during and before the COVID-19 pandemi... Read More about Quality of acute myocardial infarction care in England and Wales during the COVID-19 pandemic: linked nationwide cohort study..

Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis. (2022)
Journal Article
Mamas. (2022). Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis

AIMS: To evaluate the impact of systematic predilation with balloon aortic valvuloplasty (BAV) on transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: We performed a systematic meta-analysis investigating patients undergoing TAVI with... Read More about Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis..

Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes (2022)
Journal Article
Borovac, J. A., Mohamed, M. O., Kontopantelis, E., Alkhouli, M., Alraies, M. C., Cheng, R. K., …Mamas, M. A. (2022). Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes. Journal of Invasive Cardiology,

Objectives. To determine the average treatment effect (ATE) of primary percutaneous coronary intervention (pPCI) versus medical treatment (MT) on in-hospital outcomes across the spectrum of frailty in patients with ST-elevation myocardial infarction... Read More about Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes.

Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes (2022)
Journal Article
Mamas. (2022). Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes. Diabetes Care, 909-918. https://doi.org/10.2337/dc21-1113

OBJECTIVE To assess associations between current use of sodium–glucose cotransporter 2 inhibitors (SGLT2is), glucagon-like peptide 1 receptor agonists (GLP-1RAs), and their combination and risk for major adverse cardiac and cerebrovascular events (M... Read More about Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes.

Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK (2022)
Journal Article
Taxiarchi, P., Kontopantelis, E., Kinnaird, T., Curzen, N., Ahmed, J., Zaman, A., …Mamas, M. A. (2022). Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK. Journal of Invasive Cardiology,

Objectives. This study examines the safety and feasibility of same-day discharge (SDD) in patients undergoing percutaneous coronary intervention (PCI) to coronary chronic total occlusions (CTOs) and explores independent associations of clinical and p... Read More about Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK.

Impact of peripheral artery disease on prognosis after percutaneous coronary intervention: Outcomes from the multicenter prospective e-ULTIMASTER registry (2022)
Journal Article
Mamas. (2022). Impact of peripheral artery disease on prognosis after percutaneous coronary intervention: Outcomes from the multicenter prospective e-ULTIMASTER registry. Atherosclerosis, 71 - 77. https://doi.org/10.1016/j.atherosclerosis.2022.01.007

Background and aims Patients with peripheral artery disease (PAD) represent a high risk group, and have an increased risk of cardiovascular events and worse cardiovascular outcomes. Our aim was to study the impact of PAD among patients undergoing per... Read More about Impact of peripheral artery disease on prognosis after percutaneous coronary intervention: Outcomes from the multicenter prospective e-ULTIMASTER registry.

Beyond the revised cardiac risk index: Validation of the hospital frailty risk score in non-cardiac surgery (2022)
Journal Article
Mamas. (2022). Beyond the revised cardiac risk index: Validation of the hospital frailty risk score in non-cardiac surgery. PloS one, e0262322 - e0262322. https://doi.org/10.1371/journal.pone.0262322

Frailty is an established risk factor for adverse outcomes following non-cardiac surgery. The Hospital Frailty Risk Score (HFRS) is a recently described frailty assessment tool that harnesses administrative data and is composed of 109 International C... Read More about Beyond the revised cardiac risk index: Validation of the hospital frailty risk score in non-cardiac surgery.

Sex differences in high-risk but indicated coronary interventions (CHiP): National report from British Cardiovascular Intervention Society Registry. (2022)
Journal Article
Shamkhani, W., Kinnaird, T., Ludman, P., Rashid, M., & Mamas, M. A. (2022). Sex differences in high-risk but indicated coronary interventions (CHiP): National report from British Cardiovascular Intervention Society Registry. Catheterization and Cardiovascular Interventions, 99(2), 447-456. https://doi.org/10.1002/ccd.30081

OBJECTIVE: To assess sex-based differences in clinical outcomes following complex and high-risk but indicated percutaneous coronary intervention (CHiP). BACKGROUND: CHiP is increasingly common in contemporary percutaneous coronary intervention (PCI)... Read More about Sex differences in high-risk but indicated coronary interventions (CHiP): National report from British Cardiovascular Intervention Society Registry..

Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis (2022)
Journal Article
Ullah, W., Gul, S., Saleem, S., Syed, M. A., Khan, M. Z., Zahid, S., …Fischman, D. L. (2022). Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis. European Heart Journal Open, 2(1), Article oeac002. https://doi.org/10.1093/ehjopen/oeac002

Aims: Combined mitral valve replacement (MVR) and coronary artery bypass graft (CABG) procedures have been the norm for patients with concomitant mitral valve disease (MVD) and coronary artery disease (CAD) with no large-scale data on their safety an... Read More about Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis.

Defining Percutaneous Coronary Intervention Complexity and Risk: An Analysis of the United Kingdom BCIS Database 2006-2016. (2022)
Journal Article
Mamas. (2022). Defining Percutaneous Coronary Intervention Complexity and Risk: An Analysis of the United Kingdom BCIS Database 2006-2016. JACC: Cardiovascular Interventions, 39 - 49. https://doi.org/10.1016/j.jcin.2021.09.039

OBJECTIVES: The authors used the BCIS (British Cardiovascular Intervention Society) database to define the factors associated with percutaneous coronary intervention (PCI) procedural complexity. BACKGROUND: Complex high-risk indicated percutaneous co... Read More about Defining Percutaneous Coronary Intervention Complexity and Risk: An Analysis of the United Kingdom BCIS Database 2006-2016..

Outcomes and regional differences in practice in a worldwide coronary stent registry (2022)
Journal Article
Mamas. (2022). Outcomes and regional differences in practice in a worldwide coronary stent registry. Heart, https://doi.org/10.1136/heartjnl-2021-320116

Objective: The primary objective was to assess the performance of a new generation thin-strut sirolimus-eluting coronary stent with abluminal biodegradable polymer in an all comer population. The secondary objective was to detail differences in conte... Read More about Outcomes and regional differences in practice in a worldwide coronary stent registry.

Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis (2022)
Journal Article
Conrotto, F., D’Ascenzo, F., Franchin, L., Bruno, F., Mamas, M. A., Toutouzas, K., …De Ferrari, G. M. (2022). Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis. Journal of Invasive Cardiology, 34(2),

Aims. To evaluate the impact of systematic predilation with balloon aortic valvuloplasty (BAV) on transcatheter aortic valve implantation (TAVI). Methods and Results. We performed a systematic meta-analysis investigating patients undergoing TAVI with... Read More about Transcatheter Aortic Valve Implantation With or Without Predilation: A Meta-Analysis.

The adverse impact of COVID-19 pandemic on cardiovascular disease prevention and management in England, Scotland and Wales: A population-scale analysis of trends in medication data (2022)
Journal Article
Mamas. (2022). The adverse impact of COVID-19 pandemic on cardiovascular disease prevention and management in England, Scotland and Wales: A population-scale analysis of trends in medication data. MedRxiv, https://doi.org/10.1101/2021.12.31.21268587

Objectives To estimate the impact of the COVID-19 pandemic on cardiovascular disease (CVD) and CVD management using routinely collected medication data as a proxy. Design Descriptive and interrupted time series analysis using anonymised individual-le... Read More about The adverse impact of COVID-19 pandemic on cardiovascular disease prevention and management in England, Scotland and Wales: A population-scale analysis of trends in medication data.

The impact of Charlson Comorbidity Index on de novo CIED procedural outcomes in the United States (2022)
Journal Article
Rashid, Mamas, & Wu. (2022). The impact of Charlson Comorbidity Index on de novo CIED procedural outcomes in the United States. Mayo Clinic Proceedings, 88-100. https://doi.org/10.1016/j.mayocp.2021.06.029

Objective To investigate the utility of Charlson comorbidity index (CCI) as a measure of comorbidity burden to predict procedural outcomes after de novo cardiac implantable electronic device (CIED) implantation. Methods All de novo CIED implantati... Read More about The impact of Charlson Comorbidity Index on de novo CIED procedural outcomes in the United States.

Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes. (2022)
Journal Article
Mamas. (2022). Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes

OBJECTIVES: To determine the average treatment effect (ATE) of primary percutaneous coronary intervention (pPCI) versus medical treatment (MT) on in-hospital outcomes across the spectrum of frailty in patients with ST-elevation myocardial infarction... Read More about Frailty Among Patients With Acute ST-Elevation Myocardial Infarction in the United States: The Impact of the Primary Percutaneous Coronary Intervention on In-Hospital Outcomes..