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Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020 (2021)
Journal Article
Mamas. (2021). Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020

Background Deaths in the first year of the COVID-19 pandemic in England & Wales have been shown to be unevenly distributed socioeconomically and geographically. However, the full scale of inequalities may have been underestimated as most measures of... Read More about Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation and region in England & Wales during 2020.

Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. (2021)
Journal Article
Mamas, M., & Mallen, C. (2021). Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. Research Square, https://doi.org/10.21203/rs.3.rs-670522/v1

Objectives: To examine the association between ß -blocker prescription and knee or hip total joint replacement (TJR) in a UK primary-care population with incident knee or hip osteoarthritis (OA). Methods: Cohort study using data from the Clinical P... Read More about Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink..

Association between serum secretory phospholipase A2 and risk of ischemic stroke. (2021)
Journal Article
Mamas. (2021). Association between serum secretory phospholipase A2 and risk of ischemic stroke. European Journal of Neurology, https://doi.org/10.1111/ene.15004

BACKGROUND AND PURPOSE: Previous literature has demonstrated an association between high serum levels of type-II secretory phospholipase A2 (sPLA2) concentration and an increased risk of coronary artery disease. However, such association has not been... Read More about Association between serum secretory phospholipase A2 and risk of ischemic stroke..

Sex Differences in Outcomes Following Left Atrial Appendage Closure. (2021)
Journal Article
Sanjoy, S. S., Choi, Y., Sparrow, R. T., Baron, S. J., Abbott, J. D., Azzalini, L., …Bagur, R. (2021). Sex Differences in Outcomes Following Left Atrial Appendage Closure. https://doi.org/10.1016/j.mayocp.2020.11.031

OBJECTIVE: To evaluate the effects of female sex on in-hospital outcomes and to provide estimates for sex-specific prediction models of adverse outcomes following left atrial appendage closure (LAAC). PATIENTS AND METHODS: Cohort-based observational... Read More about Sex Differences in Outcomes Following Left Atrial Appendage Closure..

Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population. (2021)
Journal Article
Sattar, Y., Mukuntharaj, P., Zghouzi, M., Suleiman, A. M., Attique, H., Ullah, W., …Alraies, M. C. (2021). Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population. High Blood Pressure and Cardiovascular Prevention, 405 - 416. https://doi.org/10.1007/s40292-021-00462-w

INTRODUCTION: The safety of renin-angiotensin-aldosterone system inhibitors (RAASi) among COVID-19 patients has been controversial since the onset of the pandemic. METHODS: Digital databases were queried to study the safety of RAASi in COVID-19. The... Read More about Safety and Efficacy of Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19 Population..

Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction. (2021)
Journal Article
Mamas. (2021). Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2021.03.057

Chronic kidney disease (CKD) in patients with ST-elevation myocardial infarction (STEMI) is associated with worse outcomes. We assessed the impact of CKD on guideline directed coronary revascularization and outcomes among STEMI patients. The Nationwi... Read More about Impact of Chronic Kidney Disease on Revascularization and Outcomes in Patients with ST-Elevation Myocardial Infarction..

In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease (2021)
Journal Article
Zghouzi, M., Moussa Pacha, H., Ullah, W., Sattar, Y., Ahmad, B., Osman, H., …Alraies, M. C. (in press). In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease. Catheterization and Cardiovascular Interventions, 98(4), https://doi.org/10.1002/ccd.29827

Background The outcome of endovascular intervention (EVI) compared vs. surgical revascularization in patients with peripheral artery disease (PAD) due to chronic total occlusion (CTO) is unknown. Methods Using the National Inpatient Sample datab... Read More about In‐hospital outcomes of endovascular versus surgical revascularization for chronic total occlusion in peripheral artery disease.

Coronary revascularisation outcomes in patients with cancer. (2021)
Journal Article
Mamas. (2021). Coronary revascularisation outcomes in patients with cancer. Heart, 507 - 516. https://doi.org/10.1136/heartjnl-2020-318531

Cancer and coronary artery disease (CAD) overlap in traditional risk factors as well as molecular mechanisms underpinning the development of these two disease states. Patients with cancer are at increased risk of developing CAD, representing a high-r... Read More about Coronary revascularisation outcomes in patients with cancer..

Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales. (2021)
Journal Article
Dafaalla, M., Rashid, M., Weston, C., Kinnaird, T., Gurm, H., Appleby, C., …Mamas, M. (2021). Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales. American Journal of Cardiology, 152, 1 - 10. https://doi.org/10.1016/j.amjcard.2021.04.032

We investigated the incidence, management, and outcomes of acute myocardial infarction (AMI) patients according to cardiac arrest location. Patients admitted with a diagnosis of AMI between January 1, 2010 to March 31, 2017 from the Myocardial Ischae... Read More about Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales..

37 Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and scai criteria fit for purpose? (2021)
Presentation / Conference
Hinton, J., Augustine, M., Gabara, L., Mariathas, M., Allan, R., Borca, F., …Curzen, N. (2021, June). 37 Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and scai criteria fit for purpose?. Paper presented at British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021

Introduction The diagnosis and clinical implication of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) is contentious, especially given its importance in the interpretation of trial data. Two accepted defi... Read More about 37 Incidence and one year outcome of periprocedural myocardial infarction following cardiac surgery: are the universal definition and scai criteria fit for purpose?.

184 Association between high-sensitivity troponin and one year mortality in 20,000 consecutive hospital patients undergoing a blood test for any reason (2021)
Presentation / Conference
Hinton, J., Mariathas, M., Gabara, L., Allan, R., Nicholas, Z., Kwok, C. S., …Curzen, N. (2021, June). 184 Association between high-sensitivity troponin and one year mortality in 20,000 consecutive hospital patients undergoing a blood test for any reason. Paper presented at British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021

Introduction High sensitivity troponin (hs-cTn) concentrations above the manufacturer recommended upper limit of normal (ULN) are seen frequently in patients without a clinical presentation consistent with an acute coronary syndrome. There is increas... Read More about 184 Association between high-sensitivity troponin and one year mortality in 20,000 consecutive hospital patients undergoing a blood test for any reason.

Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study (2021)
Journal Article
Mamas. (2021). Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study. https://doi.org/10.22541/au.162273979.95865645/v1

Background: Higher anticholinergic burden from medications is associated with increased risk of cardiovascular disease and cognitive function decline. A mechanistic pathway has never been established. We aimed to determine whether chronic inflammati... Read More about Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study.

Incidence and mortality due to thromboembolic events during the COVID-19 pandemic: Multi-sourced population-based health records cohort study. (2021)
Journal Article
Mamas, & Rashid. (2021). Incidence and mortality due to thromboembolic events during the COVID-19 pandemic: Multi-sourced population-based health records cohort study. Thrombosis Research, 17 - 23. https://doi.org/10.1016/j.thromres.2021.03.006

BACKGROUND: Evidence supports an excess of deaths during the COVID-19 pandemic. We report the incidence and mortality of thrombo-embolic events (TE) during the COVID-19 pandemic. METHODS: Multi-sourced nationwide cohort study of adults (age =18 years... Read More about Incidence and mortality due to thromboembolic events during the COVID-19 pandemic: Multi-sourced population-based health records cohort study..

Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England. (2021)
Journal Article
Mamas, & Nolan. (2021). Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England. Circulation: Cardiovascular Interventions, 532-543. https://doi.org/10.1161/CIRCINTERVENTIONS.120.010413

Background: Aortic stenosis requires timely treatment with either surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). This study aimed to investigate the indirect impact of coronavirus disease 2019 (COVID-19) o... Read More about Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England..

Sex-Based Differences in Prevalence and Outcomes of Common Acute Conditions Associated With Type 2 Myocardial Infarction. (2021)
Journal Article
Mohamed, M. O., Contractor, T., Abramov, D., Parwani, P., Michos, E. D., Fischman, D., …Mamas, M. (2021). Sex-Based Differences in Prevalence and Outcomes of Common Acute Conditions Associated With Type 2 Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2021.02.011

Little is known about the association between acute prevalent conditions in patients with type 2 Myocardial Infarction (T2MI) and clinical outcomes, particularly between genders. Using the Nationwide Inpatient Sample (2017), we examined outcomes of T... Read More about Sex-Based Differences in Prevalence and Outcomes of Common Acute Conditions Associated With Type 2 Myocardial Infarction..

TRENDS OF IN-HOSPITAL AND 30-DAY MORTALITY AFTER PERCUTANEOUS CORONARY INTERVENTION IN ENGLAND BEFORE AND AFTER THE COVID-19 ERA (2021)
Presentation / Conference
Mohamed, M., Curzen, N., Ludman, P., Rashid, M., Shoaib, A., de Belder, M., …Mamas, M. (2021, May). TRENDS OF IN-HOSPITAL AND 30-DAY MORTALITY AFTER PERCUTANEOUS CORONARY INTERVENTION IN ENGLAND BEFORE AND AFTER THE COVID-19 ERA. Poster presented at ACC.21, Virtual

Background Public reporting of percutaneous coronary intervention (PCI) outcomes is a performance metric and a requirement in many healthcare systems. There are inconsistent data on the causes of death after PCI, and what proportion of these are att... Read More about TRENDS OF IN-HOSPITAL AND 30-DAY MORTALITY AFTER PERCUTANEOUS CORONARY INTERVENTION IN ENGLAND BEFORE AND AFTER THE COVID-19 ERA.