All Outputs (757)

Chronic kidney disease, worsening renal function and outcomes in a heart failure community setting: A UK national study (2018)
Journal Article
Mamas. (2018). Chronic kidney disease, worsening renal function and outcomes in a heart failure community setting: A UK national study. International Journal of Cardiology, 120 - 127. https://doi.org/10.1016/j.ijcard.2018.04.090

Background Routine heart failure (HF) monitoring and management is in the community but the natural course of worsening renal function (WRF) and its influence on HF prognosis is unknown. We investigated the influence of routinely monitored renal decl... Read More about Chronic kidney disease, worsening renal function and outcomes in a heart failure community setting: A UK national study.

A feasibility study of transaxillary TAVI with the lotus valve (2018)
Journal Article
Mamas. (2018). A feasibility study of transaxillary TAVI with the lotus valve. Catheterization and Cardiovascular Interventions, 542 -549. https://doi.org/10.1002/ccd.27409

Objectives To assess the feasibility of axillary transcatheter aortic valve implantation (TAVI) using the Lotus valve. Background TAVI is used to treat patients with severe aortic stenosis, with transfemoral (TF) access being the safest and most... Read More about A feasibility study of transaxillary TAVI with the lotus valve.

P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement (2018)
Journal Article
Nagaraja, V., Generaeux, P., Cohen, M., Suh, W., Alasnag, M., Potts, J., …Research Group, K. C. (2018). P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy566.p6029

Background: Patients undergoing transcatheter aortic valve replacement (TAVR) are often multi-morbid. Whilst the impact of individual comorbid conditions on clinical outcomes following TAVR have been previously assessed, the impact of more global mea... Read More about P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement.

P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data (2018)
Journal Article
Mohamed, M. O., Kinnaird, T., Kwok, C. S., Rashid, M., Anderson, R., Martin, G., …Mamas, M. A. (2018). P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy563.p4592

Background: Patients presenting with acute coronary syndrome (ACS) represent a heterogeneous population with various risk factors for coronary ischaemia and bleeding. Current ESC guidelines recommend potent dual antiplatelet therapy (DAPT), and cardi... Read More about P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data.

5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study (2018)
Journal Article
Rashid, M., Potts, J., Kwok, C., Mohammed, M., Shoaib, A., Esnsor, J., …Mamas, M. (2018). 5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy566.5258

Background: Non-ST-elevation acute coronary syndromes (NSTEACS) remains most vulnerable phenotype of acute myocardial infarction despite significant improvements in treatment and provision of guideline-recommended care. Coronary angiography (CA) is t... Read More about 5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study.

Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke (2018)
Journal Article
Barlas, R. S., Loke, Y. K., Mamas, M. A., Bettencourt-Silva, J. H., Ford, I., Clark, A. B., …Myint, P. K. (2018). Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke. American Journal of Cardiology, 122(6), 1085-1090. https://doi.org/10.1016/j.amjcard.2018.05.043

The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes. We analysed prospectiv... Read More about Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke.

Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry (2018)
Journal Article
Mamas. (2018). Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry. Cardiovascular Medicine, https://doi.org/10.1136/bmjopen-2018-022543

Objectives Previous studies indicate frailty to be associated with poor outcomes following transcatheter aortic valve implantation (TAVI), but there is limited evidence from multicentre registries. The aim was to investigate the independent associat... Read More about Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry.

Percutaneous coronary intervention of saphenous vein grafts: where do we stand? (2018)
Journal Article
Bulluck, H., Bagur, R., & Mamas, M. A. (2018). Percutaneous coronary intervention of saphenous vein grafts: where do we stand?. EuroIntervention, 14(2), 142-143. https://doi.org/10.4244/EIJV14I2A22

Saphenous vein grafts (SVG) are known to be more susceptible to accelerated atherosclerosis than native coronary arteries1. Accelerated atherosclerosis in SVG develops from resident foam cells, which then undergo apoptosis to form necrotic cores1. Th... Read More about Percutaneous coronary intervention of saphenous vein grafts: where do we stand?.

NATIONAL ANALYSIS OF RARE BUT CATASTROPHIC BLEEDING COMPLICATIONS AFTER PERCUTANEOUS CORONARY INTERVENTIONS: INSIGHTS FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY DATABASE (2018)
Journal Article
Kwok, C. S., Kontopantelis, E., Ludman, P., de Belder, M., & Mamas, M. (2018). NATIONAL ANALYSIS OF RARE BUT CATASTROPHIC BLEEDING COMPLICATIONS AFTER PERCUTANEOUS CORONARY INTERVENTIONS: INSIGHTS FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY DATABASE. Heart, 104, A53-A53. https://doi.org/10.1136/heartjnl-2018-BCS.59

Background Major bleeding is a recognised complication after PCI. This study aims to evaluate the incidence, trends over time, predictors and prognostic significance of intracranial, gastrointestinal and retroperitoneal bleeding after PCI. Methods... Read More about NATIONAL ANALYSIS OF RARE BUT CATASTROPHIC BLEEDING COMPLICATIONS AFTER PERCUTANEOUS CORONARY INTERVENTIONS: INSIGHTS FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY DATABASE.

Pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis (2018)
Journal Article
Solo, K., Lavi, S., Choudhury, T., Martin, J., Nevis, I. F., Kwok, C. S., …Bagur, R. (2018). Pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis. Journal of thoracic disease, 10(6), 3444-+. https://doi.org/10.21037/jtd.2018.05.187

Background: Aspirin therapy improves saphenous vein graft (SVG) patency in patients undergoing coronary artery bypass graft (CABG), however, its use in the pre-operative period remains controversial. Therefore, we conducted a systematic review and me... Read More about Pre-operative use of aspirin in patients undergoing coronary artery bypass grafting: a systematic review and updated meta-analysis.

Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study (2018)
Journal Article
Marshall, M., Peat, G., Nicholls, E., Myers, H. L., Mamas, M. A., & Van Der Windt, D. A. (in press). Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study. Scandinavian Journal of Rheumatology, 48(1), 52-63. https://doi.org/10.1080/03009742.2018.1459831

OBJECTIVE: To determine whether selected metabolic factors are associated with greater amounts of radiographic hand osteoarthritis (OA) incidence and progression. METHODS: The study identified 706 adults, aged 50-69 years, with hand pain and hand rad... Read More about Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study.

Temporal Changes in Comorbidity Burden in Patients Having Percutaneous Coronary Intervention and Impact on Prognosis (2018)
Journal Article
Potts, J., Kwok, C., Ensor, J., Rashid, M., Kadam, U., Kinnaird, T., …Mamas, M. (2018). Temporal Changes in Comorbidity Burden in Patients Having Percutaneous Coronary Intervention and Impact on Prognosis. American Journal of Cardiology, 122(5), 712-722. https://doi.org/10.1016/j.amjcard.2018.05.003

This study aims to evaluate the impact of comorbidity burden on outcomes among patients who undergo percutaneous coronary intervention (PCI). We used the Nationwide Inpatient Sample to identify all PCI procedures undertaken in the United States betwe... Read More about Temporal Changes in Comorbidity Burden in Patients Having Percutaneous Coronary Intervention and Impact on Prognosis.

Patient experiences of living with heart failure and diabetes (2018)
Presentation / Conference
Wu, L., Cleator, J., Mamas, M., & Deaton, C. (2018, June). Patient experiences of living with heart failure and diabetes. Poster presented at EuroHeartCare 2018, Dublin, Ireland

Backgrounds: The presence of multi-morbidity makes self management even more complex for those with heart failure (HF). Although diabetes is a common co-morbidity in the HF population, the experiences of living with both HF and diabetes and the impac... Read More about Patient experiences of living with heart failure and diabetes.

Incidence, determinants and outcomes of left and right radial access use in patients undergoing percutaneous coronary intervention in the United Kingdom, a national perspective using the British Cardiovascular Intervention Society (BCIS) dataset (2018)
Journal Article
de Belder, M., Nolan, J., Mamas, M., Kinnaird, T., Ludman, P., Potts, J., …Rashid, M. (2018). Incidence, determinants and outcomes of left and right radial access use in patients undergoing percutaneous coronary intervention in the United Kingdom, a national perspective using the British Cardiovascular Intervention Society (BCIS) dataset. JACC. Cardiovascular interventions, 11(11), 1021-1033. https://doi.org/10.1016/j.jcin.2018.01.252

Objectives The authors sought to determine the relationships between left radial access (LRA) or right radial access (RRA) and clinical outcomes using the British Cardiovascular Intervention Society (BCIS) database. Background LRA has been shown... Read More about Incidence, determinants and outcomes of left and right radial access use in patients undergoing percutaneous coronary intervention in the United Kingdom, a national perspective using the British Cardiovascular Intervention Society (BCIS) dataset.

Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis (2018)
Presentation / Conference
Wu, P., Gulati, M., Kwok, C., Wong, C., Narain, A., O'Brien, S., …Mamas, M. (2018, April). Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis. Poster presented at British Maternal & Fetal Medicine Society (BMFMS) 20th Annual Conference 2018, Brighton, UK

Objectives We aimed to systematically evaluate and summarise the evidence on the relationship between preterm birth (

Heart Failure in Acute Ischaemic Stroke and Intracerebral Haemorrhage - impact on mortality and recurrence A Thailand National Stroke Cohort Study (2018)
Presentation / Conference
Pana, T., Wood, A., Perdomo-Lampignano, J., Tiamkao, S., Clark, A., Kongbunkiat, K., …Myint, P. (2018, April). Heart Failure in Acute Ischaemic Stroke and Intracerebral Haemorrhage - impact on mortality and recurrence A Thailand National Stroke Cohort Study. Paper presented at 27th European Stroke Conference

Background: The interaction between heart failure (HF) and acute cerebrovascular disease is unclear. Data on acute ischaemic stroke (AIS) recurrence and intracerebral haemorrhage (ICH) mortality and recurrence in HF patients are limited. We thus aime... Read More about Heart Failure in Acute Ischaemic Stroke and Intracerebral Haemorrhage - impact on mortality and recurrence A Thailand National Stroke Cohort Study.

Myocardial infarction after stroke - incidence, mortality, and time-dependent predictive co-morbid factors (2018)
Presentation / Conference
Pana, T., Wood, A., Perdomo-Lampignano, J., Tiamkao, S., Clark, A., Kongbunkiat, K., …Myint, P. (2018, April). Myocardial infarction after stroke - incidence, mortality, and time-dependent predictive co-morbid factors. Presented at European Stroke Conference, Athens, Greece

Choice of antiplatelet therapy affects mortality outcome in ischemic stroke - a cohort study (2018)
Presentation / Conference
Barlas, R., Loke, Y., Mamas, M., Bettencourt-Silva, J., Ford, I., Clark, A., …Myint, P. (2018, April). Choice of antiplatelet therapy affects mortality outcome in ischemic stroke - a cohort study. Paper presented at European Stroke Conference, Athens, Greece

Background and Purpose: The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes... Read More about Choice of antiplatelet therapy affects mortality outcome in ischemic stroke - a cohort study.

Antithrombotic therapy in patients receiving saphenous vein coronary artery bypass grafts: a protocol for a systematic review and network meta-analysis. (2018)
Journal Article
Mamas. (2018). Antithrombotic therapy in patients receiving saphenous vein coronary artery bypass grafts: a protocol for a systematic review and network meta-analysis. BMJ Open, e019555 - ?. https://doi.org/10.1136/bmjopen-2017-019555

INTRODUCTION: The current evidence for the prevention of saphenous vein graft failure (SVGF) after coronary artery bypass graft (CABG) surgery consists of direct head-to-head comparison of treatments (including placebo) in randomised-controlled trial... Read More about Antithrombotic therapy in patients receiving saphenous vein coronary artery bypass grafts: a protocol for a systematic review and network meta-analysis..

Severity domains for quantifying the severity of Type 2 diabetes using primary care data and linked hospitalisation records from England (2018)
Presentation / Conference
ZGHEBI, S., Rutter, M., Ashcroft, D., Van Marwijk, H., Mallen, C., Chew-Graham, C. A., …Kontopantelis, E. (2018, March). Severity domains for quantifying the severity of Type 2 diabetes using primary care data and linked hospitalisation records from England. Poster presented at Diabetes UK Professional Conference 2018, London ExCeL, London, UK

Aims: Despite the increasing prevalence of Type 2 diabetes, which presents a significant burden on healthcare resources, there is no agreed validated UK measure to infer Type 2 diabetes severity from electronic health records (EHRs). This study aimed... Read More about Severity domains for quantifying the severity of Type 2 diabetes using primary care data and linked hospitalisation records from England.