All Outputs (139)

Change in angiogram-derived management strategy of patients with chest pain when some FFR data are available: How consistent is the effect? (2017)
Journal Article
Mamas. (2017). Change in angiogram-derived management strategy of patients with chest pain when some FFR data are available: How consistent is the effect?. Cardiovascular Revascularization Medicine, 320-327. https://doi.org/10.1016/j.carrev.2017.01.014

Background The assessment of patients presenting with angina using invasive angiography alone is imperfect. By contrast, fractional flow reserve (FFR) allows for assessment of lesion-specific ischemia, which is predictive of clinical outcome. A seri... Read More about Change in angiogram-derived management strategy of patients with chest pain when some FFR data are available: How consistent is the effect?.

Preeclampsia and Future Cardiovascular Health (2017)
Journal Article
Wu, P., Haththotuwa, R., Shing Kwok, C., Babu, A., Kotronias, R. A., Rushton, C., …Mamas, M. A. (2017). Preeclampsia and Future Cardiovascular Health. Circulation: Cardiovascular Quality and Outcomes, 10(2), https://doi.org/10.1161/circoutcomes.116.003497

Background— Preeclampsia is a pregnancy-specific disorder resulting in hypertension and multiorgan dysfunction. There is growing evidence that these effects persist after pregnancy. We aimed to systematically evaluate and quantify the evidence on th... Read More about Preeclampsia and Future Cardiovascular Health.

Pre-implantation Balloon Aortic Valvuloplasty and Clinical Outcomes Following Transcatheter Aortic Valve Implantation: A Propensity Score Analysis of the UK Registry (2017)
Journal Article
Mamas. (2017). Pre-implantation Balloon Aortic Valvuloplasty and Clinical Outcomes Following Transcatheter Aortic Valve Implantation: A Propensity Score Analysis of the UK Registry. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.116.004695

Background Aortic valve predilation with balloon aortic valvuloplasty (BAV) is recommended before transcatheter aortic valve implantation (TAVI), despite limited data around the requirement of this preprocedural step and the potential risks of embol... Read More about Pre-implantation Balloon Aortic Valvuloplasty and Clinical Outcomes Following Transcatheter Aortic Valve Implantation: A Propensity Score Analysis of the UK Registry.

Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom (2017)
Journal Article
Hulme, W., Sperrin, M., Kontopantelis, E., Ratib, K., Ludman, P., Sirker, A., …Mamas, M. (2017). Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom. Circulation: Cardiovascular Interventions, 10(2), 4279. https://doi.org/10.1161/CIRCINTERVENTIONS.116.004279

Background— The radial artery is increasingly adopted as the primary access site for cardiac catheterization because of patient preference, lower bleeding rates, cost effectiveness, and reduced risk of mortality in high-risk patient groups. Concerns... Read More about Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom.

Variation in emergency percutaneous coronary intervention in ventilated patients in the UK: insights from a national database (2017)
Journal Article
Mamas. (2017). Variation in emergency percutaneous coronary intervention in ventilated patients in the UK: insights from a national database. Cardiovascular Revascularization Medicine, 250-254. https://doi.org/10.1016/j.carrev.2017.02.005

Aims Pre-procedural ventilation is a marker of high risk in PCI patients. Causes include out-of-hospital cardiac arrest (OHCA) and cardiogenic shock. OHCA occurs in approximately 60,000 patients in the UK per annum. No consensus exists regarding the... Read More about Variation in emergency percutaneous coronary intervention in ventilated patients in the UK: insights from a national database.

Impact of HIV on inpatient mortality and complications in stroke in Thailand; A National Database Study (2017)
Journal Article
Mamas. (2017). Impact of HIV on inpatient mortality and complications in stroke in Thailand; A National Database Study. Epidemiology and Infection, 1285-1291. https://doi.org/10.1017/S095026881600340X

The co-existence of stroke and HIV has increased in recent years, but the impact of HIV on post-stroke outcomes is poorly understood. We examined the impact of HIV on inpatient mortality, length of acute hospital stay and complications (pneumonia, re... Read More about Impact of HIV on inpatient mortality and complications in stroke in Thailand; A National Database Study.

Response to letter by Dziewierz et al. on “Influence of access site choice for cardiac catheterization on risk of adverse neurological events: A systematic review and meta- analysis” (2017)
Journal Article
Mamas. (2017). Response to letter by Dziewierz et al. on “Influence of access site choice for cardiac catheterization on risk of adverse neurological events: A systematic review and meta- analysis”. American Heart Journal, 107-119. https://doi.org/10.1016/j.ahj.2017.01.013

Letter to the editor.

Endothelial progenitor cells: exploring the pleiotropic effects of statins (2017)
Journal Article
Mamas. (2017). Endothelial progenitor cells: exploring the pleiotropic effects of statins. World Journal of Cardiology, 1-13. https://doi.org/10.4330/wjc.v9.i1.1

Statins have become a cornerstone of risk modification for ischaemic heart disease patients. A number of studies have shown that they are effective and safe. However studies have observed an early benefit in terms of a reduction in recurrent infarct... Read More about Endothelial progenitor cells: exploring the pleiotropic effects of statins.

One-month global longitudinal strain identifies patients who will develop pacing-induced left ventricular dysfunction over time: the pacing and ventricular dysfunction (PAVD) study (2017)
Journal Article
Mamas. (2017). One-month global longitudinal strain identifies patients who will develop pacing-induced left ventricular dysfunction over time: the pacing and ventricular dysfunction (PAVD) study. PloS one, https://doi.org/10.1371/journal.pone.0162072

Background Predicting which individuals will have a decline in left ventricular (LV) function after pacemaker implantation remains an important challenge. We investigated whether LV global longitudinal strain (GLS), measured by 2D speckle tracking s... Read More about One-month global longitudinal strain identifies patients who will develop pacing-induced left ventricular dysfunction over time: the pacing and ventricular dysfunction (PAVD) study.

Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients (2017)
Journal Article
Mamas. (2017). Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients. American Journal of Cardiology, 284-289. https://doi.org/10.1016/j.amjcard.2016.09.036

Radiotherapy can affect the electronic components of a cardiac implantable electronic device (CIED) resulting in malfunction and/or damage. We sought to assess the incidence, predictors, and clinical impact of CIED dysfunction (CIED-D) after radiothe... Read More about Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients.

Clinical Prediction in Defined Populations: a simulation study investigating when and how to aggregate existing models (2017)
Journal Article
Mamas. (2017). Clinical Prediction in Defined Populations: a simulation study investigating when and how to aggregate existing models. BMC medical research methodology, 1-11. https://doi.org/10.1186/s12874-016-0277-1

Background Clinical prediction models (CPMs) are increasingly deployed to support healthcare decisions but they are derived inconsistently, in part due to limited data. An emerging alternative is to aggregate existing CPMs developed for similar sett... Read More about Clinical Prediction in Defined Populations: a simulation study investigating when and how to aggregate existing models.

Impact of Co-morbid burden on mortality in patients with coronary heart disease, heart failure and cerebrovascular accident: a systematic review and meta-analysis (2017)
Journal Article
Mamas, M., & Rashid, M. (2017). Impact of Co-morbid burden on mortality in patients with coronary heart disease, heart failure and cerebrovascular accident: a systematic review and meta-analysis. European Heart Journal - Quality of Care and Clinical Outcomes, 20-36. https://doi.org/10.1093/ehjqcco/qcw025

Aims: We sought to investigate the prognostic impact of co-morbid burden as defined by the Charlson comorbidity index (CCI) in patients with a range of prevalent cardiovascular diseases. Methods & Results: We searched MEDLINE and EMBASE to identify s... Read More about Impact of Co-morbid burden on mortality in patients with coronary heart disease, heart failure and cerebrovascular accident: a systematic review and meta-analysis.

Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis. Drug Safety, 229-240. https://doi.org/10.1007/s40264-016-0481-2

Introduction Thienopyridines are a class of antiplatelet drugs widely used in cardiovascular disease prevention and treatment. A recent concern has come to light regarding the safety of thienopyridines because of the possible risk of malignancy. We... Read More about Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis.

Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis (2016)
Journal Article
Nagaraja, V., Ooi, S., Nolan, J., Large, A., De Belder, M., Ludman, P., …Mamas, M. A. (2016). Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 5(12), https://doi.org/10.1161/JAHA.116.004598

Background Up to half of patients undergoing percutaneous coronary intervention have multivessel coronary artery disease (MVD) with conflicting data regarding optimal revascularization strategy in such patients. This paper assesses the evidence for... Read More about Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis.

Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry (2016)
Journal Article
Mamas, M. A., Shing Kwok, C., Kontopantelis, E., Fryer, A. A., Buchan, I., Bachmann, M. O., …Myint, P. K. (2016). Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry. Journal of the American Heart Association, 5(11), https://doi.org/10.1161/JAHA.116.003348

BACKGROUND: We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort. METHODS AND... Read More about Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry.

Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry (2016)
Journal Article
Mamas. (2016). Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.116.003348

Background We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort. Methods... Read More about Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry.

Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis (2016)
Journal Article
Davies, & Mamas. (2016). Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis. International Journal of Cardiology, 122-128. https://doi.org/10.1016/j.ijcard.2016.11.136

Background Ultrafiltration is a method used to achieve diuresis in acute decompensated heart failure (ADHF) when there is diuretic resistance, but its efficacy in other settings is unclear. We therefore conducted a systematic review and meta-analysi... Read More about Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis.

Review of early hospitalization after percutaneous coronary intervention (2016)
Journal Article
Mamas. (2016). Review of early hospitalization after percutaneous coronary intervention. International Journal of Cardiology, 370-377. https://doi.org/10.1016/j.ijcard.2016.11.050

Background Percutaneous coronary intervention (PCI) is the most common modality of revascularization in patients with coronary artery disease. Understanding the readmission rates and reasons for readmission after PCI is important because readmission... Read More about Review of early hospitalization after percutaneous coronary intervention.

Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation (2016)
Journal Article
Mamas. (2016). Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation. American Heart Journal, 97-105. https://doi.org/10.1016/j.ahj.2016.10.020

Background The performance of emerging transcatheter aortic valve implantation (TAVI) clinical prediction models (CPMs) in national TAVI cohorts distinct from those where they have been derived is unknown. This study aimed to investigate the perform... Read More about Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation.

Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system (2016)
Journal Article
Mamas, M., & Mallen, C. (2016). Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system. Medicine, e4973. https://doi.org/10.1097/md.0000000000004973

Multimorbidity is common among older people and presents a major challenge to health systems worldwide. Metrics of multimorbidity are, however, crude: focusing on measuring comorbid conditions at single time-points rather than reflecting the longitud... Read More about Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system.