All Outputs (6)

Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age (2018)
Journal Article
Martins, D., de Medeiros, V., Wajchenberg, M., Paredes-Gamero, E., Andrade De Lima, M., Reginato, R., Nader, H., Puertas, E., & Faloppa, F. (2018). Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age. PloS one, 13, e0203932--e0203932. https://doi.org/10.1371/journal.pone.0203932

Objective
This study evaluates molecular, nutritional and biochemical alterations in human intervertebral discs between middle and old age.

Methods
Twenty-eight human lumbar intervertebral discs from donors were evaluated and separated into two... Read More about Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age.

Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger (2018)
Journal Article
de Godoy, C., Vasques, Ê., Caricati-Neto, A., Tavares, J., Alves, B., Duarte, J., Miranda-Ferreira, R., Andrade De Lima, M., Nader, H., & dos Santos Tersariol, I. (2018). Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger. Frontiers in Cardiovascular Medicine, 5, https://doi.org/10.3389/fcvm.2018.00067

Background: Blockage of the Na+/Ca2+ exchanger (NCX) is used to determine the role of NCX in arrhythmogenesis. Trisulfated heparin disaccharide (TD) and Low Molecular Weight Heparins (LMWHs) can directly interact with the NCX and accelerate its activ... Read More about Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger.

Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection (2018)
Journal Article
Vicenzi, E., Pagani, I., Ghezzi, S., Taylor, S. L., Rudd, T. R., Lima, M. A., Skidmore, M., & Yates, E. A. (2018). Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection. Biochemical Society Transactions, 46, 609-617. https://doi.org/10.1042/BST20170399

Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese Encephalitis (JEV), West Nile (WNV) and Zika (ZIKV) viruses, infect a broad range of hosts, ce... Read More about Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection.

Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans (2018)
Journal Article
Rogerson, E., Pelletier, J., Acosta-Serrano, A., Rose, C., Taylor, S., Guimond, S., Lima, M., Skidmore, M., & Yates, E. (2018). Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans. Pathogens an international, open access journal of pathogens and pathogen-host interactions, 7, https://doi.org/10.3390/pathogens7010032

Tsetse flies are the principal insect vectors of African trypanosomes-sleeping sickness in humans and Nagana in cattle. One of the tsetse fly species, Glossina morsitans morsitans, is host to the parasite, Trypanosoma brucei, a major cause of African... Read More about Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans.

2, 3-Di-O-sulfo glucuronic acid: an unmodified and unusual residue in a highly sulfated chondroitin sulfate from Litopenaeus vannamei (2018)
Journal Article
Cavalcante, R., Brito, A., Palhares, L., Andrade De Lima, M., Cavalheiro, R., Nader, H., Sassaki, G., & Chavante, S. (2018). 2, 3-Di-O-sulfo glucuronic acid: an unmodified and unusual residue in a highly sulfated chondroitin sulfate from Litopenaeus vannamei. Carbohydrate Polymers, 183, 192--200. https://doi.org/10.1016/j.carbpol.2017.12.018

The occurrence of a natural and unmodified highly sulfated chondroitin sulfate from Litopenaeus vannamei heads (sCS) is herein reported. Its partial digestion by Chondroitinases AC and ABC together with its electrophoretic migration profile revealed... Read More about 2, 3-Di-O-sulfo glucuronic acid: an unmodified and unusual residue in a highly sulfated chondroitin sulfate from Litopenaeus vannamei.

Anti-IIa activity and antitumor properties of a hybrid heparin/heparan sulfate-like compound from Litopenaeus vannamei shrimp (2018)
Journal Article
Brito, A., Cavalcante, R., Cavalheiro, R., Palhares, L., Nobre, L., Andrade, G., Nader, H., Lima, M., & Chavante, S. (2018). Anti-IIa activity and antitumor properties of a hybrid heparin/heparan sulfate-like compound from Litopenaeus vannamei shrimp. International Journal of Biological Macromolecules, 118, 1470--1478. https://doi.org/10.1016/j.ijbiomac.2018.06.143