All Outputs (6)

P2X 7 receptor activity regulation: the role of CD44 proteoglycan GAG chains (2015)
Journal Article

P2X7 receptors have received special attention in the literature for their involvement in several diseases characterized by inflammatory processes such as cancer, arthritis, neurodegenerative pathologies and chronic pains.

Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans (2015)
Journal Article

Here, we present evidence for the positive allosteric modulation of the P2X7 receptor through glycosaminoglycans (GAGs) in CHO (cell line derived from the ovary of the Chinese hamster) cells. The marked potentiation of P2X7 activity through GAGs in t... Read More about Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans.

Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli (2015)
Journal Article

Quinolones and fluoroquinolones are widely used to treat uropathogenic Escherichia coli infections. Bacterial resistance to these antimicrobials primarily involves mutations in gyrA and parC genes. To date, no studies have examined the potential rela... Read More about Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli.

SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells (2015)
Journal Article

Background SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS influences signaling events mediated by heparan sulfate proteoglycans (HSPGs) located on cell... Read More about SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells.

Heparan sulfate and heparin interactions with proteins (2015)
Journal Article

Development of new methods for determining the heparanase enzymatic activity (2015)
Journal Article