Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1

Mycroft-West, Courtney J.; Abdelkarim, Sahar; Duyvesteyn, Helen M. E.; Gandhi, Neha S.; Skidmore, Mark A.; Owens, Raymond J.; Wu, Liang

doi:10.1038/s41467-024-45419-4

All Outputs (1)

Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1 (2024)
Journal Article
Mycroft-West, C. J., Abdelkarim, S., Duyvesteyn, H. M. E., Gandhi, N. S., Skidmore, M. A., Owens, R. J., & Wu, L. (in press). Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1. Nature Communications, 15(1), Article 1326. https://doi.org/10.1038/s41467-024-45419-4

Heparan sulfate (HS) polysaccharides are major constituents of the extracellular matrix, which are involved in myriad structural and signaling processes. Mature HS polysaccharides contain complex, non-templated patterns of sulfation and epimerization... Read More about Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1.