Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice

Walter, Lisa M.; Deguise, Marc-Olivier; Meijboom, Katharina E.; Betts, Corinne A.; Ahlskog, Nina; van Westering, Tirsa L.E.; Hazell, Gareth; McFall, Emily; Kordala, Anna; Hammond, Suzan M.; Abendroth, Frank; Murray, Lyndsay M.; Shorrock, Hannah K.; Prosdocimo, Domenick A.; Haldar, Saptarsi M.; Jain, Mukesh K.; Gillingwater, Thomas H.; Claus, Peter; Kothary, Rashmi; Wood, Matthew J.A.; Bowerman, Melissa

doi:10.1016/j.ebiom.2018.04.024

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Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice (2018)
Journal Article
Walter, L. M., Deguise, M., Meijboom, K. E., Betts, C. A., Ahlskog, N., van Westering, T. L., …Bowerman, M. (2018). Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice. EBioMedicine, 226-242. https://doi.org/10.1016/j.ebiom.2018.04.024

The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is a... Read More about Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice.