All Outputs (5)

Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed. (2023)
Journal Article
Levis, B., Snell, K. I., Damen, J. A., Hattle, M., Ensor, J., Dhiman, P., …Riley, R. D. (in press). Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed. Journal of Clinical Epidemiology, S0895-4356(23)00282-2. https://doi.org/10.1016/j.jclinepi.2023.10.022

Risk of bias assessments are important in meta-analyses of both aggregate and individual participant data (IPD). There is limited evidence on whether and how risk of bias of included studies or datasets in IPD meta-analyses (IPDMAs) is assessed. We r... Read More about Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed..

Mechanisms of action of therapeutic exercise for knee and hip OA remain a black box phenomenon: an individual patient data mediation study with the OA Trial Bank (2023)
Journal Article
Runhaar, J., A Holden, M., Hattle, M., Quicke, J., Healey, E. L., van der Windt, D., …Menek, M. Y. (2023). Mechanisms of action of therapeutic exercise for knee and hip OA remain a black box phenomenon: an individual patient data mediation study with the OA Trial Bank. RMD Open, 9(3), Article e003220. https://doi.org/10.1136/rmdopen-2023-003220

Objectives: To evaluate mediating factors for the effect of therapeutic exercise on pain and physical function in people with knee/hip osteoarthritis (OA). Methods: For Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (... Read More about Mechanisms of action of therapeutic exercise for knee and hip OA remain a black box phenomenon: an individual patient data mediation study with the OA Trial Bank.

Two‐stage or not two‐stage? That is the question for IPD meta‐analysis projects (2023)
Journal Article
Riley, R. D., Ensor, J., Hattle, M., Papadimitropoulou, K., & Morris, T. P. (in press). Two‐stage or not two‐stage? That is the question for IPD meta‐analysis projects. Research Synthesis Methods, 14(6), 903-910. https://doi.org/10.1002/jrsm.1661

Individual participant data meta‐analysis (IPDMA) projects obtain, check, harmonise and synthesise raw data from multiple studies. When undertaking the meta‐analysis, researchers must decide between a two‐stage or a one‐stage approach. In a two‐stage... Read More about Two‐stage or not two‐stage? That is the question for IPD meta‐analysis projects.

Calculating the power of a planned individual participant data meta‐analysis of randomised trials to examine a treatment‐covariate interaction with a time‐to‐event outcome (2023)
Journal Article
Riley, R. D., Collins, G. S., Hattle, M., Whittle, R., & Ensor, J. (in press). Calculating the power of a planned individual participant data meta‐analysis of randomised trials to examine a treatment‐covariate interaction with a time‐to‐event outcome. Research Synthesis Methods, https://doi.org/10.1002/jrsm.1650

Before embarking on an individual participant data meta‐analysis (IPDMA) project, researchers should consider the power of their planned IPDMA conditional on the studies promising their IPD and their characteristics. Such power estimates help inform... Read More about Calculating the power of a planned individual participant data meta‐analysis of randomised trials to examine a treatment‐covariate interaction with a time‐to‐event outcome.

Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis (2023)
Journal Article
Holden, M. A., Hattle, M., Runhaar, J., Riley, R. D., Healey, E. L., Quicke, J., …Exercise Collaborative, O. T. B. (2023). Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis. The Lancet Rheumatology, 5(7), e386-e400. https://doi.org/10.1016/S2665-9913%2823%2900122-4

Background Many international clinical guidelines recommend therapeutic exercise as a core treatment for knee and hip osteoarthritis. We aimed to identify individual patient-level moderators of the effect of therapeutic exercise for reducing pain an... Read More about Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis.