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818 NEITHER ANALYSIS APPROACH NOR RISK OF BIAS EXPLAIN THE LIMITED OVERALL BENEFIT OF THERAPEUTIC EXERCISE FOR KNEE AND/OR HIP OSTEOARTHRITIS IN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS (2024)
Presentation / Conference
Runhaar, J., Holden, M., Hattle, M., Quicke, J., Healey, E. L., van der Windt, D., …Foster, N. (2024, April). 818 NEITHER ANALYSIS APPROACH NOR RISK OF BIAS EXPLAIN THE LIMITED OVERALL BENEFIT OF THERAPEUTIC EXERCISE FOR KNEE AND/OR HIP OSTEOARTHRITIS IN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults. (2024)
Journal Article
Archer, L., Relton, S. D., Akbari, A., Best, K., Bucknall, M., Conroy, S., …investigators, T. E. (2024). Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults. Age and ageing, 53(3), Article afae057. https://doi.org/10.1093/ageing/afae057

Falls are common in older adults and can devastate personal independence through injury such as fracture and fear of future falls. Methods to identify people for falls prevention interventions are currently limited, with high risks of bias in publish... Read More about Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults..

Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed. (2023)
Journal Article
Levis, B., Snell, K. I., Damen, J. A., Hattle, M., Ensor, J., Dhiman, P., …Riley, R. D. (in press). Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed. Journal of Clinical Epidemiology, S0895-4356(23)00282-2. https://doi.org/10.1016/j.jclinepi.2023.10.022

Risk of bias assessments are important in meta-analyses of both aggregate and individual participant data (IPD). There is limited evidence on whether and how risk of bias of included studies or datasets in IPD meta-analyses (IPDMAs) is assessed. We r... Read More about Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed..

Mechanisms of action of therapeutic exercise for knee and hip OA remain a black box phenomenon: an individual patient data mediation study with the OA Trial Bank (2023)
Journal Article
Runhaar, J., A Holden, M., Hattle, M., Quicke, J., Healey, E. L., van der Windt, D., …Menek, M. Y. (2023). Mechanisms of action of therapeutic exercise for knee and hip OA remain a black box phenomenon: an individual patient data mediation study with the OA Trial Bank. RMD Open, 9(3), Article e003220. https://doi.org/10.1136/rmdopen-2023-003220

Objectives: To evaluate mediating factors for the effect of therapeutic exercise on pain and physical function in people with knee/hip osteoarthritis (OA). Methods: For Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (... Read More about Mechanisms of action of therapeutic exercise for knee and hip OA remain a black box phenomenon: an individual patient data mediation study with the OA Trial Bank.

Two‐stage or not two‐stage? That is the question for IPD meta‐analysis projects (2023)
Journal Article
Riley, R. D., Ensor, J., Hattle, M., Papadimitropoulou, K., & Morris, T. P. (in press). Two‐stage or not two‐stage? That is the question for IPD meta‐analysis projects. Research Synthesis Methods, 14(6), 903-910. https://doi.org/10.1002/jrsm.1661

Individual participant data meta‐analysis (IPDMA) projects obtain, check, harmonise and synthesise raw data from multiple studies. When undertaking the meta‐analysis, researchers must decide between a two‐stage or a one‐stage approach. In a two‐stage... Read More about Two‐stage or not two‐stage? That is the question for IPD meta‐analysis projects.

Calculating the power of a planned individual participant data meta‐analysis of randomised trials to examine a treatment‐covariate interaction with a time‐to‐event outcome (2023)
Journal Article
Riley, R. D., Collins, G. S., Hattle, M., Whittle, R., & Ensor, J. (in press). Calculating the power of a planned individual participant data meta‐analysis of randomised trials to examine a treatment‐covariate interaction with a time‐to‐event outcome. Research Synthesis Methods, https://doi.org/10.1002/jrsm.1650

Before embarking on an individual participant data meta‐analysis (IPDMA) project, researchers should consider the power of their planned IPDMA conditional on the studies promising their IPD and their characteristics. Such power estimates help inform... Read More about Calculating the power of a planned individual participant data meta‐analysis of randomised trials to examine a treatment‐covariate interaction with a time‐to‐event outcome.

Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis (2023)
Journal Article
Holden, M. A., Hattle, M., Runhaar, J., Riley, R. D., Healey, E. L., Quicke, J., …Exercise Collaborative, O. T. B. (2023). Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis. The Lancet Rheumatology, 5(7), e386-e400. https://doi.org/10.1016/S2665-9913%2823%2900122-4

Background Many international clinical guidelines recommend therapeutic exercise as a core treatment for knee and hip osteoarthritis. We aimed to identify individual patient-level moderators of the effect of therapeutic exercise for reducing pain an... Read More about Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis.

Exercise Therapy Compared To Usual Care In People With Early-Stage Knee Oa: An Individual Patient Data Meta-Analysis From The Oa Trial Bank (2023)
Presentation / Conference
van Middelkoop, M., Schiphof, D., Hattle, M., Simkins, J., Bennell, K., Hinman, R., …Bierma-Zeinstra, S. (2023, March). Exercise Therapy Compared To Usual Care In People With Early-Stage Knee Oa: An Individual Patient Data Meta-Analysis From The Oa Trial Bank. Presented at 2023 OARSI World Congress on Osteoarthritis, Sheraton Denver Downtown Hotel, Denver, USA

Calculating the power to examine treatment-covariate interactions when planning an individual participant data meta-analysis of randomized trials with a binary outcome. (2022)
Journal Article
Hattle, M., Riley, R. D., Collins, G. S., Whittle, R., & Ensor, J. (2022). Calculating the power to examine treatment-covariate interactions when planning an individual participant data meta-analysis of randomized trials with a binary outcome. Statistics in Medicine, 41(24), 4822-4837. https://doi.org/10.1002/sim.9538

Before embarking on an individual participant data meta-analysis (IPDMA) project, researchers and funders need assurance it is worth their time and cost. This should include consideration of how many studies are promising their IPD and, given the cha... Read More about Calculating the power to examine treatment-covariate interactions when planning an individual participant data meta-analysis of randomized trials with a binary outcome..

Multivariate meta-analysis of multiple outcomes: characteristics and predictors of borrowing of strength from Cochrane reviews. (2022)
Journal Article
Hattle. (2022). Multivariate meta-analysis of multiple outcomes: characteristics and predictors of borrowing of strength from Cochrane reviews. Systematic Reviews, 149 - ?. https://doi.org/10.1186/s13643-022-01999-0

OBJECTIVES: Multivariate meta-analysis allows the joint synthesis of multiple outcomes accounting for their correlation. This enables borrowing of strength (BoS) across outcomes, which may lead to greater efficiency and even different conclusions com... Read More about Multivariate meta-analysis of multiple outcomes: characteristics and predictors of borrowing of strength from Cochrane reviews..

Association between antihypertensive treatment and adverse events: systematic review and meta-analysis (2021)
Journal Article
Albasri, A., Hattle, M., Koshiaris, C., Dunnigan, A., Paxton, B., Emma Fox, S., …Sheppard, J. P. (2021). Association between antihypertensive treatment and adverse events: systematic review and meta-analysis. BMJ, 372, https://doi.org/10.1136/bmj.n189

OBJECTIVE: To examine the association between antihypertensive treatment and specific adverse events. DESIGN: Systematic review and meta-analysis. ELIGIBILITY CRITERIA: Randomised controlled trials of adults receiving antihypertensives compare... Read More about Association between antihypertensive treatment and adverse events: systematic review and meta-analysis.

Individual participant data meta-analysis to examine interactions between treatment effect and participant-level covariates: statistical recommendations for conduct and planning (2020)
Journal Article
Hattle. (2020). Individual participant data meta-analysis to examine interactions between treatment effect and participant-level covariates: statistical recommendations for conduct and planning. Statistics in Medicine, https://doi.org/10.1002/sim.8516

Precision medicine research often searches for treatment-covariate interactions, which refers to when a treatment effect (eg, measured as a mean difference, odds ratio, hazard ratio) changes across values of a participant-level covariate (eg, age, ge... Read More about Individual participant data meta-analysis to examine interactions between treatment effect and participant-level covariates: statistical recommendations for conduct and planning.

Predictors of the effects of treatment for shoulder pain: protocol of an individual participant data meta-analysis (2019)
Journal Article
van der Windt, D. A., Burke, D. L., Babatunde, O., Hattle, M., McRobert, C., Littlewood, C., …Riley, R. D. (2019). Predictors of the effects of treatment for shoulder pain: protocol of an individual participant data meta-analysis. Diagnostic and Prognostic Research, 15 -?. https://doi.org/10.1186/s41512-019-0061-x

Background Shoulder pain is one of the most common presentations of musculoskeletal pain with a 1-month population prevalence of between 7 and 26%. The overall prognosis of shoulder pain is highly variable with 40% of patients reporting persistent p... Read More about Predictors of the effects of treatment for shoulder pain: protocol of an individual participant data meta-analysis.