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Combinations of bleeding and ischemic risk and their association with clinical outcomes in acute coronary syndrome. (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). Combinations of bleeding and ischemic risk and their association with clinical outcomes in acute coronary syndrome. International Journal of Cardiology, 7-14. https://doi.org/10.1016/j.ijcard.2019.05.035

Acute coronary syndromes (ACS) are an important cause of morbidity and mortality worldwide. Current guidelines recommend early management with potent antiplatelet agents and an early invasive coronary intervention strategy for both non-ST elevation m... Read More about Combinations of bleeding and ischemic risk and their association with clinical outcomes in acute coronary syndrome..

Effect of Concomitant Atrial Fibrillation on In-Hospital Outcomes of Non-ST-Elevation-Acute Coronary Syndrome Related Hospitalizations in the United States (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). Effect of Concomitant Atrial Fibrillation on In-Hospital Outcomes of Non-ST-Elevation-Acute Coronary Syndrome Related Hospitalizations in the United States. American Journal of Cardiology, 465-475. https://doi.org/10.1016/j.amjcard.2019.05.040

Atrial fibrillation (AF) is the most common arrhythmia in patients presenting with acute coronary syndrome (ACS). The present study examined the rates and trends of clinical outcomes and management strategies of non-ST-elevation ACS (NSTE-ACS) relate... Read More about Effect of Concomitant Atrial Fibrillation on In-Hospital Outcomes of Non-ST-Elevation-Acute Coronary Syndrome Related Hospitalizations in the United States.

Prevalence, outcomes and costs according to patient frailty status for 2.9 million cardiac electronic device implantations in the United States (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). Prevalence, outcomes and costs according to patient frailty status for 2.9 million cardiac electronic device implantations in the United States. Canadian Journal of Cardiology, 1465-1474. https://doi.org/10.1016/j.cjca.2019.07.632

Background: Little is known about the impact of frailty on length of stay (LOS), cost and inhospital procedural outcomes of cardiac implantable electronic device (CIED) implantation procedures.

Methods: All de novo CIED implantations recorded in t... Read More about Prevalence, outcomes and costs according to patient frailty status for 2.9 million cardiac electronic device implantations in the United States.

Acute Myocardial Infarction in Severe Mental Illness: prevalence, clinical outcomes and process of care in United States hospitalizations. (2019)
Journal Article
Farooq, S., Chew-Graham, C., Mamas, M., & Rashid, M. (2019). Acute Myocardial Infarction in Severe Mental Illness: prevalence, clinical outcomes and process of care in United States hospitalizations. Canadian Journal of Cardiology, 821-830. https://doi.org/10.1016/j.cjca.2019.04.021

Patients with severe mental illness (SMI) are a high-risk group for cardiovascular disease. The present study examined the prevalence and outcomes of SMI patients in a national AMI cohort. SMI has doubled in prevalence amongst AMI patients, mainly du... Read More about Acute Myocardial Infarction in Severe Mental Illness: prevalence, clinical outcomes and process of care in United States hospitalizations..

British Cardiovascular Intervention Society registry framework: a quality improvement initiative on behalf of the National Institute of Cardiovascular Outcomes Research (NICOR) (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). British Cardiovascular Intervention Society registry framework: a quality improvement initiative on behalf of the National Institute of Cardiovascular Outcomes Research (NICOR). European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcz023

Aims
The British Cardiovascular Intervention Society (BCIS) percutaneous coronary intervention (PCI) registry is hosted by the National Institute of Cardiovascular Outcomes Research (NICOR) at Bart’s Heart Centre and collects clinical characteristic... Read More about British Cardiovascular Intervention Society registry framework: a quality improvement initiative on behalf of the National Institute of Cardiovascular Outcomes Research (NICOR).

Mode of presentation and mortality amongst patients hospitalized with heart failure?: a report from The First Euro Heart Failure Survey (2019)
Journal Article
Shoaib, A., Farag, M., Nolan, J., Rigby, A., Patwala, A., Rashid, M., …Cleland, J. (2019). Mode of presentation and mortality amongst patients hospitalized with heart failure?: a report from The First Euro Heart Failure Survey. Zeitschrift für Kardiologie, 108, 510-519. https://doi.org/10.1007/s00392-018-1380-6

Background:
Heart failure is heterogeneous in aetiology, pathophysiology and presentation. Despite this diversity, clinical trials of patients hospitalized for HF deal with this problem as a single entity, which may be one reason for repeated failur... Read More about Mode of presentation and mortality amongst patients hospitalized with heart failure?: a report from The First Euro Heart Failure Survey.

Temporal trends and predictors of time to coronary angiography following non-ST-elevation acute coronary syndrome in the USA (2019)
Journal Article
Fischman, D., Martinez, S., Potts, J., Mohamed, M., Kwok, C., Capers, Q., …Mamas, M. (2019). Temporal trends and predictors of time to coronary angiography following non-ST-elevation acute coronary syndrome in the USA. Coronary Artery Disease, 159-170. https://doi.org/10.1097/MCA.0000000000000693

OBJECTIVE:
This study aims to investigate the temporal trends in utilization of invasive coronary angiography (CA) at different time points and changing profiles of patients undergoing CA following non-ST-elevation acute coronary syndrome (NSTEACS)... Read More about Temporal trends and predictors of time to coronary angiography following non-ST-elevation acute coronary syndrome in the USA.

Timing and causes of unplanned readmissions after percutaneous coronary intervention: Insights from the Nationwide Readmission Database (2019)
Journal Article
Mamas, M., & Rashid, M. (2019). Timing and causes of unplanned readmissions after percutaneous coronary intervention: Insights from the Nationwide Readmission Database. JACC. Cardiovascular interventions, 734-748. https://doi.org/10.1016/j.jcin.2019.02.007

The rates and causes of readmission at different time periods after PCI remain incompletely elucidated. Among the 2,412,000 patients, 2.5% were readmitted between 0-7 days, 7.6% between 8 and 30 days, 8.9% between 31 and 90 days, and 8.0% between 91... Read More about Timing and causes of unplanned readmissions after percutaneous coronary intervention: Insights from the Nationwide Readmission Database.

Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts (2018)
Journal Article
Shoaib, A., Kinnaird, T., Curzen, N., Kontopantelis, E., Ludman, P., de Belder, M., …Mamas, M. (2018). Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts. Circulation: Cardiovascular Interventions, 11(11), https://doi.org/10.1161/circinterventions.118.006824

Background: There are limited data on outcomes of patients with previous CABG presenting with NSTEMI undergoing PCI. We compare clinical characteristics and outcomes in NSTEMI patients undergoing PCI with or without prior CABG surgery in a national c... Read More about Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts.

Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review (2018)
Journal Article
Ayyaz Ul Haq, M., Rashid, M., Gilchrist, I. C., Bertrand, O., Shing Kwok, C., Wai Wong, C., …Mamas, M. A. (2018). Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review. Circulation Journal, 82(11), 2736. https://doi.org/10.1253/circj.CJ-18-0389

Background

We sought to systematically review the available literature on limb dysfunction after transradial or transfemoral cardiac catheterization.

Methods & Results
MEDLINE and EMBASE were searched for studies evaluating any transradial or... Read More about Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review.

Association of different antiplatelet therapies with mortality after primary percutaneous coronary intervention (2018)
Journal Article
Mamas, & Rashid. (2018). Association of different antiplatelet therapies with mortality after primary percutaneous coronary intervention. Heart, 1683-1690. https://doi.org/10.1136/heartjnl-2017-312366

Objectives Prasugrel and ticagrelor both reduce ischaemic endpoints in high-risk acute coronary syndromes, compared with clopidogrel. However, comparative outcomes of these two newer drugs in the context of primary percutaneous coronary intervention... Read More about Association of different antiplatelet therapies with mortality after primary percutaneous coronary intervention.

Persistent sex disparities in clinical outcomes with percutaneous coronary intervention: Insights from 6.6 million PCI precedures in the United States (2018)
Journal Article
Ensor, J., Burke, D., Kwok, C., Riley, R., Holmvang, L., Mamas, M., …Rashid, M. (2018). Persistent sex disparities in clinical outcomes with percutaneous coronary intervention: Insights from 6.6 million PCI precedures in the United States. PloS one, https://doi.org/10.1371/journal.pone.0203325

Background
Prior studies have reported inconsistencies in the baseline risk profile, comorbidity burden and their association with clinical outcomes in women compared to men. More importantly, there is limited data around the sex differences and how... Read More about Persistent sex disparities in clinical outcomes with percutaneous coronary intervention: Insights from 6.6 million PCI precedures in the United States.

Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States (2018)
Journal Article
Al Shaibi, K., Gulati, R., Bell, M., Anderson, V., Potts, J., Rashid, M., …Kwok, C. (2018). Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States. JACC. Cardiovascular interventions, 1354-1364. https://doi.org/10.1016/j.jcin.2018.03.049

Discharge against medical advice (DAMA) in the context of PCI has not been described in the literature. Among the 2,021,104 patients, the proportion of patients who DAMA was 0.5% (n=10,049). Important predictors of DAMA included diagnosis of acute my... Read More about Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States.

Relation Between Age and Unplanned Readmissions After Percutaneous Coronary Intervention (Findings From The Nationwide Readmission Database) (2018)
Journal Article
Martinez, S., Rao, S., Gilchrist, I., Kwok, C., Al Ayoubi, F., Myint, P., …Kontopantelis, E. (2018). Relation Between Age and Unplanned Readmissions After Percutaneous Coronary Intervention (Findings From The Nationwide Readmission Database). American Journal of Cardiology, 220-228. https://doi.org/10.1016/j.amjcard.2018.03.367

It is unclear how age affects rates and causes of unplanned early readmissions after per cutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database in the United States from 2010 to 2014 and examined the impact... Read More about Relation Between Age and Unplanned Readmissions After Percutaneous Coronary Intervention (Findings From The Nationwide Readmission Database).

Accelerated patent haemostasis using a procoagulant disk: a protocol designed to minimise the risk of radial artery occlusion following cardiac catheterisation (2018)
Journal Article
Ayyaz Ul Haq, M., Nazir, S. A., Rashid, M., Shing Kwok, C., Mubashiruddin, S., Alisiddiq, Z., …Nolan, J. (2019). Accelerated patent haemostasis using a procoagulant disk: a protocol designed to minimise the risk of radial artery occlusion following cardiac catheterisation. Cardiovascular Revascularization Medicine, 20(2), 137-142. https://doi.org/10.1016/j.carrev.2018.03.026

Purpose
Radial artery occlusion flowing cardiac catheterisation has been linked to flow reduction and prolonged compression. We investigate whether these factors can be optimised following transradial cardiac catheterisation by using an accelerated... Read More about Accelerated patent haemostasis using a procoagulant disk: a protocol designed to minimise the risk of radial artery occlusion following cardiac catheterisation.

Burden of 30-day readmissions after PCI in 824,747 patients in the USA: predictors, causes and cost. Insights from the Nationwide Readmission Database (2018)
Journal Article
Rashid, M., Curzen, N., Nolan, J., Bagur, R., Mamas, M., Potts, J., …Kwok, C. (2018). Burden of 30-day readmissions after PCI in 824,747 patients in the USA: predictors, causes and cost. Insights from the Nationwide Readmission Database. JACC. Cardiovascular interventions, 655-674. https://doi.org/10.1016/j.jcin.2018.01.248

Objectives
This study aimed to examine the 30-day unplanned readmissions rate, predictors of readmission, causes of readmissions, and clinical impact of readmissions after percutaneous coronary intervention (PCI).

Background
Unplanned rehospital... Read More about Burden of 30-day readmissions after PCI in 824,747 patients in the USA: predictors, causes and cost. Insights from the Nationwide Readmission Database.

Effect of Gender On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmissions Database) (2018)
Journal Article
Kwok, C., Potts, J., Gulati, M., Alasnag, M., Rashid, M., Shoaib, A., …Mamas, M. (2018). Effect of Gender On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmissions Database). American Journal of Cardiology, 810-817. https://doi.org/10.1016/j.amjcard.2017.12.032

Women who undergo percutaneous coronary intervention (PCI) are at higher risk of adverse outcomes compared with men, but it is unknown whether gender affects early unplanned rehospitalization. We analyzed 832,753 patients who underwent PCI from 2013... Read More about Effect of Gender On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmissions Database).

Mortality after percutaneous coronary revascularization: Prior cardiovascular risk factor control and improved outcomes in patients with diabetes mellitus. (2017)
Journal Article
Mamas, M., & Rashid, M. (2017). Mortality after percutaneous coronary revascularization: Prior cardiovascular risk factor control and improved outcomes in patients with diabetes mellitus. Catheterization and Cardiovascular Interventions, 1195-1204. https://doi.org/10.1002/ccd.26882

OBJECTIVES: To assess the mortality in patients with diabetes mellitus (DM) following percutaneous coronary intervention (PCI) according to their insulin requirement and PCI setting (elective, urgent, and emergency). BACKGROUND: DM is a major risk fa... Read More about Mortality after percutaneous coronary revascularization: Prior cardiovascular risk factor control and improved outcomes in patients with diabetes mellitus..

Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis (2017)
Journal Article
Rashid, & Mamas. (2017). Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis. International Journal of Cardiology, 145-153. https://doi.org/10.1016/j.ijcard.2017.04.037

Background
Aortic stenosis (AS) poses a perioperative management dilemma to physicians looking after patients who require non-cardiac surgery. The objective of this review is to investigate mortality and adverse cardiovascular events in patients wit... Read More about Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis.

Impact of Co-morbid burden on mortality in patients with coronary heart disease, heart failure and cerebrovascular accident: a systematic review and meta-analysis (2017)
Journal Article
Mamas, M., & Rashid, M. (2017). Impact of Co-morbid burden on mortality in patients with coronary heart disease, heart failure and cerebrovascular accident: a systematic review and meta-analysis. European Heart Journal - Quality of Care and Clinical Outcomes, 20-36. https://doi.org/10.1093/ehjqcco/qcw025

Aims: We sought to investigate the prognostic impact of co-morbid burden as defined by the Charlson comorbidity index (CCI) in patients with a range of prevalent cardiovascular diseases. Methods & Results: We searched MEDLINE and EMBASE to identify s... Read More about Impact of Co-morbid burden on mortality in patients with coronary heart disease, heart failure and cerebrovascular accident: a systematic review and meta-analysis.