All Outputs (2)

Autophagy is inhibited by ubiquitin ligase activity in the nervous system (2019)
Journal Article
Crawley, O., Opperman, K. J., Desbois, M., Adrados, I., Borgen, M. A., Giles, A. C., …Grill, B. (2019). Autophagy is inhibited by ubiquitin ligase activity in the nervous system. Nature Communications, 10, Article 5017. https://doi.org/10.1038/s41467-019-12804-3

Autophagy is an intracellular catabolic process prominent in starvation, aging and disease. Neuronal autophagy is particularly important, as it affects the development and function of the nervous system, and is heavily implicated in neurodegenerative... Read More about Autophagy is inhibited by ubiquitin ligase activity in the nervous system.

A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function (2019)
Journal Article
Giles, A. C., Desbois, M., Opperman, K. J., Tavora, R., Maroni, M. J., & Grill, B. (2019). A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Journal of biological chemistry, 294(17), 6843-6856. https://doi.org/10.1074/jbc.ra119.007406

Inhibitory GABAergic transmission is required for proper circuit function in the nervous system. However, our understanding of molecular mechanisms that preferentially influence GABAergic transmission, particularly presynaptic mechanisms, remains lim... Read More about A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function.