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All Outputs (14)

DECELLULARISED PLEURAL PATCHES FOR PROLONGED ALVEOLAR AIR LEAKS (2021)
Presentation / Conference
Vikranth, T., Dale, T., & Forsyth, N. (2021, November). DECELLULARISED PLEURAL PATCHES FOR PROLONGED ALVEOLAR AIR LEAKS. Presented at TERMIS 6th World Congress, Maastricht, Netherlands

Prolonged alveolar air leaks (PALs) as post‐surgical complications to lung resections at an incidence of 26%, is a source of patient morbidity. The gold standard approach to managing PALs is conservative, through extended duration of chest tube drain... Read More about DECELLULARISED PLEURAL PATCHES FOR PROLONGED ALVEOLAR AIR LEAKS.

Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis (2021)
Presentation / Conference
Kay, A. G., Treadwell, K., Roach, P., Morgan, R., Lodge, R., Hyland, M., …Kehoe, O. (2021, September). Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis. Poster presented at 6th European Congress of Immunology, Virtual meeting

Novel biological therapies have revolutionised the management of Rheumatoid Arthritis (RA) but no cure currently exists. Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion... Read More about Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis.

CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE (2018)
Presentation / Conference
Chen, L., Merkhan, M., Forsyth, N. R., & Wu, P. (2018, September). CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE. Poster presented at International Federation of Placenta Associations Meeting, Tokyo, Japan

Objectives: Chorionic and amniotic MSCs (CMSCs/AMSCs) are derived
from different sides of placental membrane. Women with a history of
gestational diabetes mellitus have a high risk of developing subsequent
diabetes. As cell therapy is a promising... Read More about CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE.

Mesenchymal stem cell derived products attenuate cytokine-induced apoptosis in pancreatic beta cells (2016)
Presentation / Conference
Al Azzawi, B., Merkhan, M. M., Kelly, C., & Forsyth, N. (2016, March). Mesenchymal stem cell derived products attenuate cytokine-induced apoptosis in pancreatic beta cells. Poster presented at Abstracts of the Diabetes UK Professional Conference 2016, Scottish Exhibition and Conference Centre, Glasgow, Scotland

Aims:Cytokine-driven beta cell apoptosis is central to Type 1diabetes. Mesenchymal stem cells (MSCs) are multipotent cellswith significant immunomodulatory capacity, which counteractautoimmunityand enhance islet engraftment and survival. The aimof th... Read More about Mesenchymal stem cell derived products attenuate cytokine-induced apoptosis in pancreatic beta cells.

Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner (2014)
Presentation / Conference
Dale, T. P., De Castro, A., Parkinson, E. K., Kuiper, N. J., & Forsyth, N. R. (2014, June). Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner. Poster presented at Tissue Engineering & Regenerative Medicine International Society, European Chapter Meeting, Magazzini del Cotone Congress Center, Genova, Italy

Introduction: Limited therapeutic options for the treatment of cartilage damage have driven the development of cell therapy alternatives. How-ever, many of the relevant cell types are difficult to study due to the rapid onset of replicative senescenc... Read More about Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner.