All Outputs (7)

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., Forsyth, N. R., Kehoe, O., & Treadwell, K. (2021). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), 126 - 126. https://doi.org/10.3390/ijms23010126

<jats:p>Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder (2021)
Journal Article
Nguyen Thanh, L., Nguyen, H.-P., Duy Ngo, M., Anh Bui, V., Dam, P. T., Thi Phuong Bui, H., Van Ngo, D., Trung Tran, K., Thi Thanh Dang, T., Duc Duong, B., Anh Thi Nguyen, P., Forsyth, N., & Heke, M. (2021). Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder. Stem Cells Translational Medicine, 10(12), 1721-1721. https://doi.org/10.1002/sct3.13043

The aim of this study was to evaluate the safety and efficacy of autologous bone marrow mononuclear cell transplantation combined with educational intervention for children with autism spectrum disorder. An open-label clinical trial was performed fro... Read More about Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder.

DECELLULARISED PLEURAL PATCHES FOR PROLONGED ALVEOLAR AIR LEAKS (2021)
Presentation / Conference
Vikranth, T., Dale, T., & Forsyth, N. (2021, November). DECELLULARISED PLEURAL PATCHES FOR PROLONGED ALVEOLAR AIR LEAKS. Presented at TERMIS 6th World Congress, Maastricht, Netherlands

Prolonged alveolar air leaks (PALs) as post‐surgical complications to lung resections at an incidence of 26%, is a source of patient morbidity. The gold standard approach to managing PALs is conservative, through extended duration of chest tube drain... Read More about DECELLULARISED PLEURAL PATCHES FOR PROLONGED ALVEOLAR AIR LEAKS.

Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis (2021)
Presentation / Conference Contribution
Kay, A. G., Treadwell, K., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., Forsyth, N. R., & Kehoe, O. (2021, September). Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis. Poster presented at 6th European Congress of Immunology, Virtual meeting

Novel biological therapies have revolutionised the management of Rheumatoid Arthritis (RA) but no cure currently exists. Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion... Read More about Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis.

Mesenchymal Stromal Cell Differentiation for Generating Cartilage and Bone-Like Tissues In Vitro. (2021)
Journal Article
Monaco, G., Ladner, Y. D., El Haj, A. J., Forsyth, N. R., Alini, M., & Stoddart, M. J. (2021). Mesenchymal Stromal Cell Differentiation for Generating Cartilage and Bone-Like Tissues In Vitro. Cells, https://doi.org/10.3390/cells10082165

In the field of tissue engineering, progress has been made towards the development of new treatments for cartilage and bone defects. However, in vitro culture conditions for human bone marrow mesenchymal stromal cells (hBMSCs) have not yet been fully... Read More about Mesenchymal Stromal Cell Differentiation for Generating Cartilage and Bone-Like Tissues In Vitro..

Do hypoxia mimetic agents provide fidelity in replication of engineered oxygen control measures in human mesenchymal stem cell isolation and culture? (2021)
Journal Article
Ahmad, M. A., & Forsyth, N. R. (2021). Do hypoxia mimetic agents provide fidelity in replication of engineered oxygen control measures in human mesenchymal stem cell isolation and culture?. Free Radical Biology and Medicine, 165, 5. https://doi.org/10.1016/j.freeradbiomed.2020.12.244

Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier (2021)
Journal Article
Dale, T., Forsyth, N., & Maffulli, N. (2021). Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier. Pharmaceutics,

Tissue engineering strategies can be relevant for cartilage repair and regeneration. A collagen matrix was functionalized with the addition of poly-lactic-co-glycolic acid microcarriers (PLGA-MCs) carrying a human Transforming Growth Factor ß1 (hTFG-... Read More about Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier.